Inhibition of Experimental Systemic Inflammation (Septic Inflammation) and Chronic Bronchitis by New Phytoformula BL Containing Broussonetia papyrifera and Lonicera japonica

Abstract

Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of inflammatory disorders in Chinese medicine, especially respiratory inflammation. Previously, a new phytoformula (BL) containing B. papyrifera and L. japonica was found to exert strong anti-inflammatory activity against several animal models of inflammation, especially against an animal model of acute bronchitis. In the present investigation, the effects of BL on animal models of septic inflammation and chronic bronchitis are examined. Against lipopolysaccharide (LPS)-induced septic inflammation in mice, BL (200-400 mg/kg) reduced the induction of some important proinflammatory cytokines. At 1 h after LPS treatment, BL was found to considerably inhibit TNF-α production when measured by cytokine array. At 3 h after LPS treatment, BL inhibited the induction of several proinflammatory cytokines, including IFN-γ and IL-1β, although dexamethasone, which was used as a reference, showed a higher inhibitory action on these biomarkers. Against chronic bronchitis induced by LPS/elastase instillation in rats for 4 weeks, BL (200-400 mg/kg/day) significantly inhibited cell recruitment in bronchoalveolar lavage fluid. Furthermore, BL considerably reduced lung injury, as revealed by histological observation. Taken together, these results indicate that BL may have a potential to treat systemic septic inflammation as well as chronic bronchitis.

Network pharmacology-based identification of key pharmacological pathways of Yin–Huang–Qing–Fei capsule acting on chronic bronchitis

“…Chronic bronchitis, a very common disease associated with chronic inflammation, is caused by a variety of etiological factors, such as air pollution, smoking, and pathogen infection 1,2. It has been predicted to be the fourth leading cause of death by 2030 3,4.…”

Antibacterial, anti-inflammatory, and antioxidant effects of Yinzhihuang injection

“…It may result in various ailments, such as bronchitis, arthritis deformans, colitis, gravis, artherosclerosis, and/or parasitic diseases [1][2][3]. Inflammatory responses caused by infectious and non-infectious external factors induce reactive oxygen and nitrogen species, which include hydrogen peroxide (H 2 O 2 ), nitric oxide (NO), and reactive intermediates such as hydroxyl radicals (OH•), superoxide (O 2 •−), and peroxynitrite (ONOO−) [4,5].…”

Etnobotánica urbana: el conocimiento botánico local sobre las plantas alimenticias y medicinales, y sus usos, en la conurbación Buenos Aires-La Plata

“…antidiabético (Siwicka et al 2011;Jin et al 2013), hipocolesterolémico, hipolipidémico, antiarterioesclerosis (Hurrell et al 2015a), protector gástrico y cardiovascular (Ma et al 2013;,antiasmático , antiosteoporosis (Jung Koo et al 2014), emenagogo (He et al 1986), nefroprotector (Zhong et al 2013), neuroprotector, potenciador de la memoria y del aprendizaje, antidepresivo, ansiolítico, anticonvulsivo (Hurrell et al 2015b), fertilidad masculina , potenciador sexual: disfunción eréctil (Hsu et al 2015) Atractylodes lancea (Thunb.) DC.…”

“…E: antiasmático (Hong et al 2013. ), infecciones del tracto respiratorio superior (Lu et al 2015), antiséptico, bronquial (Ko et al 2013;), antialérgico, antidermatósico (Tian et al 2012), febrífugo, antioxidante, cardioprotector, antiinflamatorio, analgésico, antimicrobiano, antiviral, hipolipidémico, hepatoprotector, citoprotector (Ryu et al 2010Shang et al 2011;Mahboob et al 2016;, anticáncer (Han et al 2016), hipoglucémico, antidiabético, anti-obesidad , antinefrítico (Tzeng et al 2014), antiartrítico (Huh et al 2012), potenciador cognitivo, neuroprotector: anti-Alzheimer (Weon et al .2011;Yu et al 2015), gastroprotector (Hue et al 2011),enfermedades intestinales , antisifilítico (Drobnik 2016). analgésico: dolor de espalda y articulaciones, antineurálgico, anticefalálgico, antitusivo, antitinnitus, vulnerario, emoliente, antiulcerogénico, infertilidad masculina, potenciador de la espermatogénesis, potenciador sexual: impotencia.…”

“…analgésico: dolor de espalda y articulaciones, antineurálgico, anticefalálgico, antitusivo, antitinnitus, vulnerario, emoliente, antiulcerogénico, infertilidad masculina, potenciador de la espermatogénesis, potenciador sexual: impotencia. neuroprotector, antidepresivo, ansiolítico (Hurrell et al 2015b), cardioprotector (Xin et al 2011), anti-osteoporosis (Jin et al 2013), antiartrítico , hepatoprotector (Xiao et al 2012), hipolipidémico, hipocolesterolémico, antiarterioesclerosis (Hurrell et al 2015a) anti-obesidad (Amagase &Nance 2011), antidiabético, nefroprotector (Zhao et al 2009;Du et al 2016) (Amagase et al 2009), inmunomodulador, antiinflamatorio (Nardi et al 2016. ), anticáncer (Mao et al 2011), potenciador de la espermatogénesis (Qian & Yu 2016), potenciador sexual: disfunción eréctil, protector testicular y prostático (Sohn et al 2008;Patel et al 2011;Semwal et al 2013).…”