Inhibition of fibronectin binding to matrix components by nonenzymatic glycosylation

Cohen, Morrel H.; Ku, L.

doi:10.2337/diabetes.33.10.970

Cited by 17 publications

(11 citation statements)

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“…51 AGE-modified fibronectin has reduced ability to support cell adhesion, spreading, and migration, 52,53 and to bind to collagen and heparin. 54 As such, the fibronectin fibrils observed in uninjured human diabetic skin may have reduced function. Fibronectin matrix mimetics promote adhesion, spreading, and migration, 24 suggesting that they may be used to overcome the irregularities in cell adhesion and migration associated with AGE-modified fibronectin from diabetic humans.…”

Section: Discussionmentioning

confidence: 99%

Fibronectin Matrix Mimetics Promote Full-Thickness Wound Repair in Diabetic Mice

Roy

Mooney²,

Raeman³

et al. 2013

Tissue Engineering Part A

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Section: Discussionmentioning

confidence: 99%

Fibronectin Matrix Mimetics Promote Full-Thickness Wound Repair in Diabetic Mice

Roy

Mooney²,

Raeman³

et al. 2013

Tissue Engineering Part A

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“…It is possible that enhanced nonenzymatic glycation of extracellular matrix proteins such as fibronectin and laminin may interfere with the synthesis and function of HSPG. It has been shown that increased nonenzymatic glycation of either fibronectin (23) or laminin (24) reduces heparin or heparan sulfate binding to these matrix proteins and thus alters macromolecular assembly of basement membranes. During this rearrangement of macromolecular assembly, it is possible that HSPG synthesis is decreased.…”

Section: Discussionmentioning

confidence: 99%

Heparan sulfate proteoglycan synthesis and its expression are decreased in the retina of diabetic rats

Bollineni¹,

Alluru²,

Reddi³

1997

Current Eye Research

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“…In our study a high fibronectin concentration may be the effect of widespread endothelial injury to small vessels. Although a recent study showed no modulation of PF function in diabetic patients receiving insulin treatment [30], some studies showed that glycated fibronectin is characterized by altered properties, especially by decreased binding to collagen and endothelial cells [9,11]. This may contribute to disturbed vessel wall integrity.…”

Section: Resultsmentioning

confidence: 99%

“…Glycated fibronectin Received: June 14, 1994 Accepted: November 26, 1994 Correspondence to: Dr. Mehmet Ali GUNDOGAN, Dept. of Endocrinology Gulhane School of Medicine, 06018 EtlikAnkara, Turkey is characterized by altered properties, especially by decreased binding to collagen and endothelial cells [7][8][9][10][11]. This may contribute to disturbed vessel wall integrity [9,11].…”

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confidence: 99%

Can We Use Plasma Fibronectin Levels as a Marker for Early Diabetic Nephropathy.

et al. 1995

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Abstract. Although increased plasma fibronectin (PF) levels have been found in diabetic patients with microalbuminuria, there is still controversy about its clinical implication for detecting early diabetic nephropathy.To evaluate the PF concentration as a possible marker for early diabetic nephropathy, three groups of sex-and age-matched patients were studied I) 22 insulin dependent diabetic (IDDM) patients with microalbuminuria (mean age ± SEM: 23.3 ± 3.6 years, mean urinary albumin excretion rate (AER) ± SEM: 47.1 ± 39.5 µg/min); II) 17 IDDM patients with normoalbuminuria (mean age: 23.4 ± 4.4 years, mean AER: 7.8 ± 2.1 µg/min) and III) 20 healthy control subjects (mean age: 22.6 ± 4.1 years, mean AER: 6.7 ± 2.1 µg/min). PF and urinary excretion of albumin were measured by an immunoturbidimetric method using commercially available kits (Boehringer Mannheim GMBH FRG, and Miles Lab., UK). The mean PF was significantly higher in the group with microalbuminuria (406.5 ± 122.9 µg/ml) than in the group with normoalbuminuria (295.6 ± 96.9 pg/ml, P<0.01) or in the control group (299.54 ± 105.5 µg/ml, P<0.01). A weak positive correlation was found between PF and urinary albumin values (r=0.35, P<0.05). There were no significant correlations between PF and the other variables such as age, duration of diabetes, body mass index, arterial blood pressure, fasting blood glucose, fructosamine and HbA1 in the diabetic patients or in the control group. Our results suggest that the PF concentration could be a weak marker for early diabetic nephropathy. We cannot therefore use PF instead of microalbuminuria because there is only a weak correlation between PF and microalbuminuria.

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Inhibition of fibronectin binding to matrix components by nonenzymatic glycosylation

Cited by 17 publications

References 0 publications

Fibronectin Matrix Mimetics Promote Full-Thickness Wound Repair in Diabetic Mice

Fibronectin Matrix Mimetics Promote Full-Thickness Wound Repair in Diabetic Mice

Heparan sulfate proteoglycan synthesis and its expression are decreased in the retina of diabetic rats

Can We Use Plasma Fibronectin Levels as a Marker for Early Diabetic Nephropathy.

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