Inhibition of fluorouracil-induced stomatitis by oral cryotherapy.

Mahood, D J; Dose, Ann Marie; Loprinzi, Charles L.; Veeder, Michael H.; Athmann, Laureen M.; Therneau, Terry M.; Sorensen, John M.; Gainey, Debra K.; Mailliard, James A.; N, Gusa

doi:10.1200/jco.1991.9.3.449

Cited by 230 publications

(148 citation statements)

References 5 publications

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“…Mucositis was reduced significantly (P = 0.002). Apart from numbness of the mouth and 'ice cream' headaches, the ice was well tolerated (Mahood et al, 1991).…”

Section: Antibioticsmentioning

confidence: 99%

Treatment-induced mucositis: an old problem with new remedies

Symonds

1998

Br J Cancer

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Summary Mucositis may be a painful, debilitating, dose-limiting side-effect of both chemotherapy and radiotherapy for which there is no widely accepted prophylaxis or effective treatment. The basis of management is pain relief, prevention of dehydration and adequate nutrition. When tested vigorously, most antiseptic mouthwashes and anti-ulcer agents are ineffective. Simple mechanical cleansing by saline is the most effective traditional measure. A variety of new agents are effective. Granulocyte macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) act outwith the haemopoeitic system and can reduce mucositis, but the best schedule, dosage and method of administration is not known or which is the best growth factor to prevent this side-effect. A placebo-controlled randomized trial of antibiotic pastilles has shown a significant reduction in mucositis and weight loss during radiotherapy for head and neck cancer. Another method to reduce radiation effects in normal tissue is to stimulate cells to divide before radiotherapy by silver nitrate or interleukin 1. These methods may be particularly effective when given along with hyperfractionated radiation treatment such as CHART.

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“…Mucositis was reduced significantly (P = 0.002). Apart from numbness of the mouth and 'ice cream' headaches, the ice was well tolerated (Mahood et al, 1991).…”

Section: Antibioticsmentioning

confidence: 99%

Treatment-induced mucositis: an old problem with new remedies

Symonds

1998

Br J Cancer

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“…Cryotherapy attenuated severity of oral mucositis under bolus application of methotrexate (MTX), 5-fluorouracil or melphalan. [105][106][107][108][109] Cytokines for prophylaxis and treatment of oral mucositis…”

Section: Mouthrinses With Anti-infective and Anesthetic Propertiesmentioning

confidence: 99%

Prophylaxis and treatment of chemo- and radiotherapy-induced oral mucositis – are there new strategies?

Karthaus

Rosenthal

Ganser

1999

Bone Marrow Transplant

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Summary:Oral mucositis is a major dose-limiting toxic effect of intensive cancer chemotherapy. Oral complications may lead to dose reduction or delay in further cancer treatment. Mucositis can be caused directly by cytotoxic effects and indirectly by sustained neutropenia after cytostatic therapy. An impaired mucosal barrier predisposes to life-threatening septic complications during aplasia. The prevalence of an oral focus in febrile neutropenia has been reported in up to 30% of cases and also reduces quality of life. The basic strategies aim at pain relief and prevention of bacterial and fungal infectious complications. However, no effective causal prophylaxis or treatment of oral mucositis is widely accepted. The introduction of cytokines, eg granulocytemacrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) for oral mucositis may be particularly effective and offer a new and hopeful approach. At present, the optimal growth factor, best schedule, effective dosage and best mode of application is not known.

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“…7,8 Additionally, there have been several reports of reduced oral mucositis in patients who kept ice chips in their mouth during infusional chemotherapy. 9,10 The scientific rationale for this approach is that cryotherapy leads to vasoconstriction and decreased blood flow to the oral cavity, which reduces the exposure of the buccal mucosa to chemotherapy. There are no randomized trials that report on the use of cryotherapy in patients receiving high-dose melphalan, and the reported single-arm studies were conducted in association with other drugs or total body irradiation.…”

Section: Introductionmentioning

confidence: 99%