Inhibition of human neutrophil 5-lipoxygenase activity by gingerdione, shogaol, capsaicin and related pungent compounds

Flynn, Daniel L.; Rafferty, Michael; Boctor, Amal M.

doi:10.1016/0262-1746(86)90126-5

Cited by 102 publications

(37 citation statements)

References 8 publications

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“…In addition, studies have shown that the anti-inflammatory effect of ginger is partly due to inhibition of cyclooxygenases (COXs) and 5-lipoxygenase [37][38][39][40]. Prostaglandin F2a is involved in leukocyte migration in the lipopolysaccharide (LPS)-induced model, since COX-2 inhibitors and COX-unspecific (indomethacin) pretreatment promoted a reduced leukocyte migratory response [41].…”

Section: Resultsmentioning

confidence: 99%

Inhibitory effects of ginger (Zingiber officinale Roscoe) essential oil on leukocyte migration in vivo and in vitro

et al. 2010

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Zingiber officinale Roscoe, popular name ginger, is grown naturally in many parts of the world, including Brazil. Ginger is used in pharmaceutical, cosmetic, and food and beverage industries and the essential oil has been used in folk medicine for manifold conditions including as an analgesic, anti-inflammatory, and antirheumatic. The purpose of this study was to investigate the effects of ginger (Zingiber officinale Roscoe) essential oil (GEO) in an in vitro chemotaxis assay and on leukocyte-endothelial interactions in vivo. GEO was analyzed by GC-MS and the main components identified were ar-curcumene (59%), β-myrcene (14%), 1,8-cineol (8%), citral (7.5%), and zingiberene (7.5%). Oral administration of GEO (200-500 mg/kg) reduced the rolling and leukocyte adherence after 2 h of carrageenan injection (100 μg) into the scrotal chamber. The number of leukocytes migrated to the perivascular tissue 4 h after the irritant stimulus was also diminished. GEO in all doses tested (10(-4), 10(-3), or 10(-2) μL/mL) caused a significant reduction of leukocyte chemotaxis (35.89 ± 4.33, 30.67 ± 0.70, and 35.85 ± 3.83%, respectively) toward casein stimuli. The data presented showed direct and systemic effects of GEO on leukocyte migration as an important mechanism of the anti-inflammatory action of ginger.

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Section: Resultsmentioning

confidence: 99%

Inhibitory effects of ginger (Zingiber officinale Roscoe) essential oil on leukocyte migration in vivo and in vitro

et al. 2010

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“…Ginger (Zingiber officinale) extracts are also reported to be powerful inhibitors of human platelet aggregation and to inhibit prostanoid formation. 58,59 However, the two effects do not appear directly related as [6]-gingerol and its analogues 60 reduce prostaglandin formation but are only weak inhibitors of platelet aggregation, whilst the labdane-type diterpenes from ginger strongly inhibit aggregation without inhibition of the arachidonic acid cascade. Evidently inhibition of aggregation requires a different mechanism from that of the organosulphur compounds derived from Allium sp.…”

Section: B Non-nutritive Dietary Components and Platelet Functionmentioning

confidence: 95%

Dietary components and human platelet activity

Duttaroy¹

2002

Platelets

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Platelet hyperactivity is one of the most important factors responsible for the incidence of cardiovascular disease. There are many nutritive and non-nutritive compounds present in the diet which may affect platelet function in various ways. Recent discovery of anti-platelet factors in plants, vegetables and fruits provides a new dietary means for a long-term strategy to favorably modify human blood platelet activity. This review summarises the effects of these dietary components on human platelet function both in vitro and in vivo.

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“…Pretreatment of rats with capsaicin (1.68 mg/kg, intraperitoneally given) for three consecutive days resulted in the enhancement of activities of pulmonary antioxidant enzymes such as superoxide dismutase, catalase and peroxidase while long-term treatment caused an opposite effect on the latter two enzymes (De and Ghosh 1990). Since reactive oxygen species are known to play an important role in phorbol-12-myristate-13-acetate (PMA)-mediated tumour promotion as well as in inflammation (Kensler et al 1986), it would be worth to determine if capsaicin with potential anti-inflammatory activity (Joe and Lokesh 1994;Flynn and Rafferty 1986) could act as an anti-tumour promoter. It is noteworthy that the inhibition of prostaglandin synthesis by curcumin, the product of tumeric, correlates well with its protective activity against reported curcumin to inactivate xanthine dehydrogenase/ oxygenase, which may account for its anti-promotion activity.…”

Section: Effects Of Capsaicin On Xenobiotic Metabolism and Chemicallymentioning

confidence: 99%

Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings

et al. 2009

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(1) The capsaicin used in the physiological and pharmacological observations (in animals and human beings) chemically represents different chemical compounds, which can be obtained from the plants (paprika, chilli, etc.), (2) capsaicinoids are able to modify the capsaicin-sensitive afferent nerves, which have principle roles in the defence of different organs (including the gastrointestinal tract [against the different chemicals, heat, strech, chemical millieu-induced damage], (3) the application of capsaicin (capsaicinoids) can be repeated for the beneficial effects on the gastrointestinal tract as those in animal experiments. After this interdisciplinary and critical review, this paper demonstrates the well-planned research pathways of the discoveries of capsaicinoids from plant chemistry, via physiology, pharmacology and toxicology in animal experiments and human observations.

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Inhibition of human neutrophil 5-lipoxygenase activity by gingerdione, shogaol, capsaicin and related pungent compounds

Cited by 102 publications

References 8 publications

Inhibitory effects of ginger (Zingiber officinale Roscoe) essential oil on leukocyte migration in vivo and in vitro

Inhibitory effects of ginger (Zingiber officinale Roscoe) essential oil on leukocyte migration in vivo and in vitro

Dietary components and human platelet activity

Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings

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