Inhibition of human seminal fluid and Leishmania donovani phosphatases by molybdate heteropolyanions

Present General Status of Understanding of Heteropoly Electrolytes and a Tracing of Some Major Highlights in the History of Their Elucidation

“…Synthesis and characterization of heteropoly complexes with high valent heteroatoms 325,444,459,469 has also been an important topic for Pope and co-workers; in some cases unusual heteroatom oxidation states are stabilized − Some of Pope's work over the years has focused on the many potentialities for geometric and steroisomerism in polyoxometalates. ,,,,, Additionally, Pope has contributed greatly to the understanding of polyoxometalate structure, chemistry, and applications with several excellent review articles and book chapters. ,3d,25b,,,,− …”

Metal Complexes as Enzyme Inhibitors

“…171 Studies employing tartrate-sensitive acid phosphatase from human seminal fluid and tartrate-resistant phosphatase from Leishmania donovani demonstrate that heteropolyanionic molybdenum complexes (with Ge, Fe, As, Ce, Th) inhibit these enzymes selectively. 172 Four classes of complexes were assayed containing 4, 6-8, 12, or 18 Mo atoms. Selectivity was assessed based on the inhibition of these enzymes and not ACP from human spleen.…”

“…Acid phosphatases (ACP) appear to be involved in the pathogenicity of leishmanias, and these phosphatases are inhibited by a number of transition metals and transition-metal complexes such as arsenate and vanadate . Studies employing tartrate-sensitive acid phosphatase from human seminal fluid and tartrate-resistant phosphatase from Leishmania donovani demonstrate that heteropolyanionic molybdenum complexes (with Ge, Fe, As, Ce, Th) inhibit these enzymes selectively …”

Lanthanide Complexes of the α-1 Isomer of the [P2W17O61]10-Heteropolytungstate: Preparation, Stoichiometry, and Structural Characterization by183W and31P NMR Spectroscopy and Europium(III) Luminescence Spectroscopy

“…Well-characterized, stable, water soluble complexants may find a number of applications in biochemistry and medicine, catalysis, separation of lanthanides and high-valent actinide ions from nuclear waste streams, and stabilization of radioactive lanthanides for radiotherapy. In the medicinal area, for example, a number of families of polyoxoanions have been shown to interact with enzymes specifically, suggesting that these compounds may be valuable for study of the structure and function of enzymes and proteins. , Polyoxoanions, including derivatives of the [α2-P 2 W 17 O 61 ] 10- isomer, have also been noted for antiviral activity . In the area of catalysis, while there are few reports of derivatives of the Wells−Dawson molecule, the “Keggin” derivatives are well-known thermal catalysts and, recently, photocatalysts, for oxidative transformation of various organic molecules in solution. 4a-f Transition metal derivatives of isomerically pure [α2-P 2 W 17 O 61 ] 10- ligand are probably among the best characterized polyoxoanion species to be subjected to oxidation catalysis studies 4g.…”