Inhibition of in vitro microsomal lipid peroxidation by isoflavonoids

Jha, Hem Chandra; Recklinghausen, G. von; Zilliken, F.

doi:10.1016/0006-2952(85)90672-0

Cited by 138 publications

(55 citation statements)

References 13 publications

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“…34 Lipid peroxidation was determined by measuring the formation of MDA with the thiobarbiturate reaction. 35 MPO Assay. Lung MPO has been used as a marker of pulmonary neutrophil infiltration and activation.…”

Section: Biochemical Determinationsmentioning

confidence: 99%

Preconditioning protects liver and lung damage in rat liver transplantation: Role of xanthine/xanthine oxidase

et al. 2002

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This study was designed to evaluate whether ischemic preconditioning could confer protection against liver and lung damage associated with liver transplantation. The effect of preconditioning on the xanthine/xanthine oxidase (XOD) system in liver grafts subjected to 8 and 16 hours of cold ischemia was also evaluated. Increased xanthine levels and marked conversion of xanthine dehydrogenase (XDH) to XOD were observed after hepatic cold ischemia. Xanthine/XOD could play a role in the liver and lung damage associated with liver transplantation. This assumption is based on the observation that inhibition of XOD reduced postischemic reactive oxygen species (ROS) generation and hepatic injury as well as ensuing lung inflammatory damage, including neutrophil accumulation, oxidative stress, and edema formation. Ischemic preconditioning reduced xanthine accumulation and conversion of XDH to XOD in liver grafts during cold ischemia. This could diminish liver and lung damage following liver transplantation. In the liver, preconditioning prevented postischemic ROS generation and hepatic injury as well as the injurious effects in the lung following liver transplantation. Administration of xanthine and XOD to preconditioned rats led to hepatic ROS and transaminase levels similar to those found after reperfusion and abolished the protective effect of preconditioning on the lung inflammatory damage. In conclusion, ischemic preconditioning reduces both liver and lung damage following liver transplantation. This endogenous protective mechanism is capable of blocking xanthine/XOD generation in liver grafts during cold ischemia. (HEPATOLOGY 2002;36:562-572.)

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Section: Biochemical Determinationsmentioning

confidence: 99%

Preconditioning protects liver and lung damage in rat liver transplantation: Role of xanthine/xanthine oxidase

et al. 2002

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“…Genistein inhibits topoisomerase Ⅱ [33] , platelet-activating factor-and epidermal growth factorinduced expression of c-fos [34] , diacylglycerol synthesis [35] , and tyrosine kinases [36] . It also inhibits microsomal lipid peroxidation [22] and angiogenesis [23] . Genistein exhibits antioxidant properties [24][25][26] and has been reported to induce differentiation of numerous cell types [27][28][29] .…”

Section: Discussionmentioning

confidence: 99%

“…Genistein inhibits microsomal lipid peroxidation [22] and angiogenesis [23] . Genistein exhibits antioxidant properties [24][25][26] and has been reported to induce differentiation of numerous cell types [27][28][29] .…”

Section: Introductionmentioning

confidence: 99%

Anticancer activity of genistein on implanted tumor of human SG7901 cells in nude mice

Zhou¹,

Chen²,

Cai³

et al. 2008

WJG

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“…This hasbeen pharmacologically shown with the effects of being antioxidant [1], potentialphytoestrogen [2,3] or inhibiting cancer cells growth [4,5], inhibiting cardiovasculardisease [6,7], and playing the role of female hormone [8]. Because the solubility of daidzein is poor, its biologicalutilization rate is low and the dose is high.…”

Section: Discussionmentioning

confidence: 99%