Inhibition of interleukin-12 and interferon-γ production in immune cells by tanshinones from Salvia miltiorrhiza

Kang, Bok Yun; Chung, Sung Min; Kim, Seung Hyun; Ryu, Shi Yong; Kim, Tae Sung

doi:10.1016/s0162-3109(00)00256-3

Cited by 122 publications

(82 citation statements)

References 29 publications

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“…2C, bottom panels). Consistent with a previous report (27), TSNIIA-SS only partially attenuated LPS-induced release of IL-12p70 (by 45 Ϯ 5%), along with a few other cytokines (such as IL-1␣ (by 50 Ϯ 7%), platelet factor 4 (by 35 Ϯ 6%), and MCP-5 (by 25 Ϯ 5%)). Taking together, these data indicate that TSNIIA-SS selectively attenuates LPS-induced release of HMGB1 as opposed to other proinflammatory cytokines.…”

Section: Water-soluble Tsniia-ss Selectively Attenuated Endotoxin-indsupporting

confidence: 91%

A Cardiovascular Drug Rescues Mice from Lethal Sepsis by Selectively Attenuating a Late-Acting Proinflammatory Mediator, High Mobility Group Box 1

Ashok

et al. 2007

The Journal of Immunology

129

171

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The pathogenesis of sepsis is mediated in part by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., TNF, IL-1, and IFN-γ) and late (e.g., high mobility group box 1 (HMGB1) protein) proinflammatory cytokines. The recent discovery of HMGB1 as a late mediator of lethal sepsis has prompted investigation for development of new experimental therapeutics. We found that many steroidal drugs (such as dexamethasone and cortisone) and nonsteroidal anti-inflammatory drugs (such as aspirin, ibuprofen, and indomethacin) failed to influence endotoxin-induced HMGB1 release even at superpharmacological concentrations (up to 10–25 μM). However, several steroid-like pigments (tanshinone I, tanshinone IIA, and cryptotanshinone) of a popular Chinese herb, Danshen (Salvia miltiorrhiza), dose dependently attenuated endotoxin-induced HMGB1 release in macrophage/monocyte cultures. A water-soluble tanshinone IIA sodium sulfonate derivative (TSNIIA-SS), which has been widely used as a Chinese medicine for patients with cardiovascular disorders, selectively abrogated endotoxin-induced HMGB1 cytoplasmic translocation and release in a glucocorticoid receptor-independent manner. Administration of TSNIIA-SS significantly protected mice against lethal endotoxemia and rescued mice from lethal sepsis even when the first dose was given 24 h after the onset of sepsis. The therapeutic effects were partly attributable to attenuation of systemic accumulation of HMGB1 (but not TNF and NO) and improvement of cardiovascular physiologic parameters (e.g., decrease in total peripheral vascular resistance and increase in cardiac stroke volume) in septic animals. Taken together, these data re-enforce the pathogenic role of HMGB1 in lethal sepsis, and support a therapeutic potential for TSNIIA-SS in the treatment of human sepsis.

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Section: Water-soluble Tsniia-ss Selectively Attenuated Endotoxin-indsupporting

confidence: 91%

A Cardiovascular Drug Rescues Mice from Lethal Sepsis by Selectively Attenuating a Late-Acting Proinflammatory Mediator, High Mobility Group Box 1

Ashok

et al. 2007

The Journal of Immunology

129

171

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“…More than 30 diterpene compounds have been separated and identified from Danshen. Actually, Danshen-derived compounds have many important pharmacology effects in basic experiments or clinic, such as anti-tumor, immunoloregulation and cardioprotective effects, and so on (Kang et al, 2000;Su and Lin, 2008;Zhou et al, 2008). Tanshinone IIA is most abundant and structurally representative of the tanshinones of Salvia miltiorrhiza (Tang and Eisenbrand, 1992).…”

Section: Discussionmentioning

confidence: 99%

Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro

et al. 2009

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Cardiac fibrosis occurs after pathological stimuli to the cardiovascular system. One of the most important factors that contribute to cardiac fibrosis is angiotensin II (Ang II). Accumulating studies have suggested that reactive oxygen species (ROS) plays an important role in cardiac fibrosis and sodium tanshinone IIA sulfonate (STS) possesses antioxidant action. We therefore examined whether STS depresses Ang II-induced collagen type I expression in cardiac fibroblasts. In this study, Ang II significantly enhanced collagen type I expression and collagen synthesis. Meanwhile, Ang II depressed matrix metalloproteinase-1 (MMP-1) expression and activity. These responses were attenuated by STS. Furthermore, STS depressed the intracellular generation of ROS, NADPH oxidase activity and subunit p47 phox expression. In addition, N-acetylcysteine the ROS scavenger, depressed effects of Ang II in a manner similar to STS. In conclusion, the current studies demonstrate that anti-fibrotic effects of STS are mediated by interfering with the modulation of ROS.

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“…12,13 Cryptotanshinone (CPT), one of the major representative components isolated from Danshen, has been reported to possess various pharmacological activities, such as anti-inflammatory, anti-angiogenic, anti-oxidative, anti-obese, and anti-diabetic functions. [14][15][16][17] Recently, CPT has also been reported to have obvious antitumor activity in a variety of cancer cells, including prostate carcinoma, hepatocarcinoma, rhabdomyosarcoma and melanoma cells. [18][19][20][21][22][23] In breast carcinoma cells, CPT has been shown to inhibit MCF7 cell proliferation by suppressing mTOR mediated CyclinD1 expression and Rb phosphorylation that lead to MCF7 cell apoptosis by inducing stress in the endoplasmic reticulum (ER).…”

Section: Introductionmentioning

confidence: 99%

Cryptotanshinone inhibits breast cancer cell growth by suppressing estrogen receptor signaling

Wang

Liu

et al. 2014

Cancer Biology & Therapy

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y These authors contributed equally to this work.Keywords: breast cancer, cryptotanshinone, estradiol, estrogen receptor Abbreviations: ER, estrogen receptor; CPT, cryptotanshinone; EREs, estrogen-responsive elements; SERM, selective estrogen receptor modulator; CADD, computer-aided drug design; ROS, reactive oxygen species.Estrogen receptor (ER) is a major therapeutic target for the treatment of breast cancer, because of the crucial role of estrogen signaling deregulation in the development and progression of breast cancer. In this study, we report the identification of a novel ERa binding compound, cryptotanshinone (CPT), by screening the CADD database. We also show that CPT effectively inhibits estrogen-induced ER transactivation and gene expression of ER target genes. Furthermore, we showed that CPT suppressed breast cancer cell growth mainly in an ERa dependent manner. Finally, we confirmed the potential therapeutic efficiency of CPT using xenograft experiments in vivo. Taken together, our results describe a novel mechanism for the anticancer activity of CPT and provide supporting evidence for its use as a potential therapeutic agent to treat patients with ERa positive breast cancer.

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Inhibition of interleukin-12 and interferon-γ production in immune cells by tanshinones from Salvia miltiorrhiza

Cited by 122 publications

References 29 publications

A Cardiovascular Drug Rescues Mice from Lethal Sepsis by Selectively Attenuating a Late-Acting Proinflammatory Mediator, High Mobility Group Box 1

A Cardiovascular Drug Rescues Mice from Lethal Sepsis by Selectively Attenuating a Late-Acting Proinflammatory Mediator, High Mobility Group Box 1

Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro

Cryptotanshinone inhibits breast cancer cell growth by suppressing estrogen receptor signaling

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