Inhibition of ionic transport and ATPase activities by serotonin analogues in the isolated toad lens

Candia, Oscar A.; Lanzetta, Peter A.; Alvarez, Lawrence J.; Gaines, William A.

doi:10.1016/0005-2736(80)90319-3

Cited by 13 publications

(5 citation statements)

References 24 publications

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“…Serotonin inhibits the ATPase at the level of lens epithelium, and the physiological activity of this membrane enzyme represents a crucial point in the maintenance of lens transparence [24]. More recently, the administration of a selective 5-HT 3 antagonist to pregnant rats has been responsible for the development of nuclear cataract in the offspring.…”

Section: Role Of Serotonin In the Eyementioning

confidence: 99%

Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure

Costagliola

Parmeggiani²,

Semeraro³

et al. 2008

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The increase in serotonin (5-HT) neurotransmission is considered to be one of the most efficacious medical approach to depression and its related disorders. The selective serotonin reuptake inhibitors (SSRIs) represent the most widely antidepressive drugs utilized in the medical treatment of depressed patients. Currently available SSRIs include fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram and escitalopram. The primary SSRIs pharmacological action’s mechanism consists in the presynaptic inhibition on the serotonin reuptake, with an increased availability of this amine into the synaptic cleft. Serotonin produces its effects as a consequence of interactions with appropriate receptors. Seven distinct families of 5-HT receptors have been identified (5-HT1 to 5-HT7), and subpopulations have been described for several of these. The interaction between serotonin and post-synaptic receptors mediates a wide range of functions. The SSRIs have a very favorable safety profile, although clinical signs of several unexpected pathologic events are often misdiagnosed, in particular, those regarding the eye. In all cases reported in the literature the angle-closure glaucoma represents the most important SSRIs-related ocular adverse event. Thus, it is not quite hazardous to hypothesize that also the other reported and unspecified visual disturbances could be attributed - at least in some cases - to IOP modifications. The knowledge of SSRIs individual tolerability, angle-closure predisposition and critical IOP could be important goals able to avoid further and more dangerous ocular side effects.

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Section: Role Of Serotonin In the Eyementioning

confidence: 99%

Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure

Costagliola

Parmeggiani²,

Semeraro³

et al. 2008

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“…Lens browning occurs from lens exposure to tryptophan and ultraviolet light (17). Inhibition of Na+K + ATPase, hydration and decreased potentials are found in lenses exposed to tryptamine (3). Sodium salicylate at 1 mmole concentration prevents the binding of tryptophan or kynurenine to human lens protein.…”

Section: E Cotiiermentioning

confidence: 99%

Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined to diabetes

Cotlier

1981

Int Ophthalmol

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The prevalence of cataracts is significantly lower in patients with rheumatoid arthritis receiving aspirin (mean of 2,700 mgs daily for an average of 10.4 years) as compared to the matched population not receiving aspirin. Similarly, fewer cataracts were found among a population with diabetes and rheumatoid arthritis receiving aspirin (mean of 2,340 mgs daily for an average of 8.8 years) as compared to the matched population on no aspirin. The effects of aspirin on cataract formation may result from 1) lowering of plasma tryptophan levels and increased excretion of tryptophan metabolites, 2) inhibition of aldose reductase and sorbitol formation in the diabetic lens, 3) inhibition of tryptophan or kynurenine binding to lens protein.

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“…Abundant fragment ions were consistent with compound C being a monooxygenated derivative of arachidonic acid with a hydroxyl substituent at carbon-12 of the icosanoid backbone; all deuterium atoms from [2Hgjarachi-donate were retained in the structure. Oxidative ozonolysis yielded products indicating double bonds between carbons at positions 10 and 11 and positions 14 and 15 of the 20-carbon chain. Compound C was, therefore, characterized as a 12-hydroxyicosatetraenoic acid.…”

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confidence: 99%

“…Ouabain was dissolved in distilled water. The reaction was terminated by the addition of 0.8 ml of color reagent containing ammonium molybdate/malachite green/sterox as described by Candia et al (14). After …”

mentioning

confidence: 99%

“…After compound C was purified by TLC and HPLC, it was found to have a UV absorption spectrum with a maximum absorbance at 236 nm suggesting the presence of a conjugated diene. Mass spectrometric analysis using positive-and negative-ionization modes was carried out on derivatized compound C that had been synthesized from a mixture of specifically labeled ([5,6,8,9,11,12,14, and unlabeled arachidonic acid. Abundant fragment ions were consistent with compound C being a monooxygenated derivative of arachidonic acid with a hydroxyl substituent at carbon-12 of the icosanoid backbone; all deuterium atoms from [2Hgjarachi-donate were retained in the structure.…”

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confidence: 99%

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12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea.

Schwartzman

Balazy

Masferrer

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

138

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When corneal microsomes were incubated with arachidonic acid in the presence of an NADPH-generating system, four polar metabolites (compounds A-D) were formed. Synthesis of these metabolites could be inhibited by carbon monoxide, SKF 525A, and anti-cytochrome c reductase antibodies. One of the metabolites, compound C, was found to inhibit partially purified Na+,K+-ATPase from the corneal epithelium in a dose-dependent manner with an ID5o of =50 nM. After compound C was purified by TLC and HPLC, it was found to have a UV absorption spectrum with a maximum absorbance at 236 nm suggesting the presence of a conjugated diene. Mass spectrometric analysis using positive-and negative-ionization modes was carried out on derivatized compound C that had been synthesized from a mixture of specifically labeled ([5,6,8,9,11,12,14, and unlabeled arachidonic acid. Abundant fragment ions were consistent with compound C being a monooxygenated derivative of arachidonic acid with a hydroxyl substituent at carbon-12 of the icosanoid backbone; all deuterium atoms from [2Hgjarachi-donate were retained in the structure.

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Inhibition of ionic transport and ATPase activities by serotonin analogues in the isolated toad lens

Cited by 13 publications

References 24 publications

Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure

Selective Serotonin Reuptake Inhibitors: A Review of its Effects on Intraocular Pressure

Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined to diabetes

12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea.

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