1999
DOI: 10.4049/jimmunol.163.5.2530
|View full text |Cite
|
Sign up to set email alerts
|

Inhibition of Kit Expression by IL-4 and IL-10 in Murine Mast Cells: Role of STAT6 and Phosphatidylinositol 3′-Kinase

Abstract: The c-kit protooncogene encodes a receptor tyrosine kinase that is known to play a critical role in hemopoiesis and is essential for mast cell growth, differentiation, and cytokine production. Studies have shown that the Th2 cytokine IL-4 can down-regulate Kit expression on human and murine mast cells, but the mechanism of this down-regulation has remained unresolved. Using mouse bone marrow-derived mast cells, we demonstrate that IL-4-mediated Kit down-regulation requires STAT6 expression and phosphotidylinos… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2001
2001
2023
2023

Publication Types

Select...
3
3

Relationship

0
6

Authors

Journals

citations
Cited by 62 publications
(1 citation statement)
references
References 58 publications
0
1
0
Order By: Relevance
“…For the Treg cells that trigger immune tolerance, some intestinal helminths such as Strinoidogyne can induce Treg secretion in mice, and thus protect against colitis in a model of colitis [21], while disruption of the intestinal flora and antibiotic drugs reduce Treg cell differentiation in the intestine of mice [21]. Metabolites of commensal bacteria such as Bacteroides fragilis polysaccharides are also involved in the induction of Treg cell differentiation and promote the development of immune tolerance [22]. For Th17 cells, which are involved in immunity to exogenous pathogens, such as K. pneumoniae, S. aureus, S. enteritidis serum, and S. flexneri [14,23], their differentiation can be induced by segmented filamentous bacterium (SFB) [24].…”
Section: Allergic Diseases and Differentiation Of T Lymphocytesmentioning
confidence: 99%
“…For the Treg cells that trigger immune tolerance, some intestinal helminths such as Strinoidogyne can induce Treg secretion in mice, and thus protect against colitis in a model of colitis [21], while disruption of the intestinal flora and antibiotic drugs reduce Treg cell differentiation in the intestine of mice [21]. Metabolites of commensal bacteria such as Bacteroides fragilis polysaccharides are also involved in the induction of Treg cell differentiation and promote the development of immune tolerance [22]. For Th17 cells, which are involved in immunity to exogenous pathogens, such as K. pneumoniae, S. aureus, S. enteritidis serum, and S. flexneri [14,23], their differentiation can be induced by segmented filamentous bacterium (SFB) [24].…”
Section: Allergic Diseases and Differentiation Of T Lymphocytesmentioning
confidence: 99%