Inhibition of Lymphocyte Function by Head and Neck Carcinoma Cell Line Soluble Factors

Bailet, Jeffrey W.; Lichtenstein, Alan; Chen, Ge; Mickel, Robert A.

doi:10.1001/archotol.1997.01900080089011

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Such factors have been found in the supernatants from sarcoma, lung carcinoma, melanoma, head-and-neck carcinoma and colon cancer; they inhibit mitogen and other strong lymphocyte responses. [1][2][3] The nature of the factors responsible for the immunosuppressive effects in many instances are unknown, but in others, a wide variety of factors have been implicated, such as PGE 2 , 4 TGF-␤2, 5,6 IL-10, 7,8 ␣-MSH, 7 IL-6, 9 hydrogen peroxide 10 and Fas ligand. 11 Immunoscreening of a cDNA library from the MM200 melanoma line with sera from a melanoma patient identified several plaques that were shown by cDNA sequence analysis to be heavychain ferritin (H-ferritin).…”

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confidence: 99%

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Immunosuppressive effects of melanoma-derived heavy-chain ferritin are dependent on stimulation of IL-10 production

et al. 2001

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confidence: 99%

“…Percentage inhibition of anti-CD3-stimulated lymphocytes with ferritin (1.1 g/ml) or supernatants from melanoma or lymphocytes.-2 rH02 (500 ng/ml) was incubated for 1 hr with supernatant or ferritin from other sources prior to addition to lymphocytes.- 3 Supernatants were collected after 24 hr from melanoma cells.…”

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confidence: 99%

Immunosuppressive effects of melanoma-derived heavy-chain ferritin are dependent on stimulation of IL-10 production

et al. 2001

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“…Squamous cell cancers were associated with the highest WI rate. Different studies suggest that squamous cell cancer induces inhibition of lymphocyte function and apoptosis in activated lymphocytes 16–19. Other studies show a high rate of malnutrition in these patients and correlation between malnutrition and postoperative major complications 20, 21…”

Section: Discussionmentioning

confidence: 99%

Previous chemotherapy as a predictor of wound infections in nonmajor head and neck surgery: Results of a prospective study

et al. 2004

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Background. The goal of this prospective study was to determine the incidence of wound infection (WI) after clean uncontaminated head and neck cancer procedures and after emergency tracheotomies.Methods. Two hundred twelve clean procedures without tracheotomy or opening of mucosa (neck dissections, large skin resections, thyroidectomies, parotid gland resections, and explorative cervicotomies) were studied at Oscar Lambret Cancer Center over a 24-month period.Results. WI rate was 6.6% (14 of 212). In a univariate analysis, only one variable was significantly related to the likelihood of WI: previous anticancer chemotherapy. All but one patient who had had previous chemotherapy demonstrated WI (14 of 15).Conclusions. After previous chemotherapy, the WI rate in clean uncontaminated head and neck surgery was as high as 90%. In this case, antibiotic prophylaxis should be evaluated.

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“…Expression of VEGF from HNSCC cells inhibits functional maturation of DCs, reducing their antigen presenting capabilities 120. HNSCC cells directly secrete several immunosuppressive cytokines, such as IL‐10, TGF‐β, and prostaglandin E2 (PGE2),121 which inhibit the local development of IFN‐γ secreting T‐lymphocytes in vitro and in vivo 122, 123. Granulocyte/monocyte‐colony stimulating factor (GM‐CSF) has been shown to have conflicting roles in HNSCC.…”

Section: Discussionmentioning

confidence: 99%

The clinical implications of antitumor immunity in head and neck cancer

et al. 2011

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Recent developments have renewed interest in understanding the interaction between transformed cells and the immune system in the tumor microenvironment. Here, we provide a comprehensive review addressing the basics of tumor immunology in relation to head and neck cancer and the cellular components potentially involved in antitumor immune responses. In addition, we describe the mechanisms by which head and neck cancer cells escape immune-mediated killing and progress to form clinically significant disease. Further, we detail what effects standard anticancer therapies may have on antitumor immune responses and how these responses may be altered by current and investigational immunotherapies. Finally, we discuss future directions that need to be considered in the development of new immunotherapeutics designed to durably alter the immune response in favor of the host.

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Inhibition of Lymphocyte Function by Head and Neck Carcinoma Cell Line Soluble Factors

Cited by 4 publications

References 25 publications

Immunosuppressive effects of melanoma-derived heavy-chain ferritin are dependent on stimulation of IL-10 production

Immunosuppressive effects of melanoma-derived heavy-chain ferritin are dependent on stimulation of IL-10 production

Previous chemotherapy as a predictor of wound infections in nonmajor head and neck surgery: Results of a prospective study

The clinical implications of antitumor immunity in head and neck cancer

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