Inhibition of microbial growth by naturally-occuring purine bases and ribonucleosides

Henderson, J. Frank

doi:10.1016/0163-7258(80)90078-9

Cited by 10 publications

(2 citation statements)

References 97 publications

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“…As shown in Fig. S3 and Table S2 and S3 in Supplemental File 1, purines, and pyrimidines, which are microbial growth factors, were downregulated, indicating that 3-PPA treatment can disrupt the metabolic pathways of purines and pyrimidines and thereby inhibit the growth of microorganisms ( 34 ). In addition, several amino acids, such as alanine, aspartate, lysine, arginine, proline, tryptophan, histidine, and glutamate, were vital in QS-related protein synthesis and decreased after 3-PPA treatment.…”

Section: Discussionmentioning

confidence: 99%

3-Phenylpropan-1-Amine Enhanced Susceptibility of Serratia marcescens to Ofloxacin by Occluding Quorum Sensing

et al. 2022

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Section: Discussionmentioning

confidence: 99%

3-Phenylpropan-1-Amine Enhanced Susceptibility of Serratia marcescens to Ofloxacin by Occluding Quorum Sensing

et al. 2022

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“…Purines are important compqrnents of nucleic acids and nucleotides. However, free purine bases can be quite toxic for bacteria and eucaryotes (19). A variety of bacteria transform or degrade purines (43).…”

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confidence: 99%

Purine and glycine metabolism by purinolytic clostridia

Dürre¹,

Andreesen²

1983

J Bacteriol

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Cell extracts of Clostridium acidiurici, C. cylindrosporum, and C. purinolyticum converted purine, hypoxanthine, 2-hydroxypurine, 6,8-dihydroxypurine, and uric acid into xanthine by the shortest possible route. Adenine was transformed to xanthine only by C. purinolyticum, whereas the other two species formed 6amino-8-hydroxypurine, which was neither deaminated nor hydroxylated further. 8-Hydroxypurine was formed from purine by all three species. Xanthine dehydrogenase activity was constitutively expressed by C. purinolyticum. Due to the lability of the enzyme activity, comparative studies could not be done with a purified preparation. All enzymes reported to be involved in formiminoglycine metabolism of C. acidiurici and C. cylindrosporum were present in C. purinolyticum. However, glycine was reduced directly to acetate in all three species, as indicated by radiochemical data and by the detection of glycine reductase in cell extracts of C. cylindrosporum and C. purinolyticum. The expression of glycine reductase and the high ratio of glycine fermented to uric acid present points to an energetic advantage for the glycine reductase system, which is expressed when selenium compounds are added to the growth media.

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Mechanisms of Toxicity of Adenosine, 2’-Deoxyadenosine, and Inhibitors of Adenosine Deaminase

Henderson¹

1983

Regulatory Function of Adenosine

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Inhibition of microbial growth by naturally-occuring purine bases and ribonucleosides

Cited by 10 publications

References 97 publications

3-Phenylpropan-1-Amine Enhanced Susceptibility of Serratia marcescens to Ofloxacin by Occluding Quorum Sensing

3-Phenylpropan-1-Amine Enhanced Susceptibility of Serratia marcescens to Ofloxacin by Occluding Quorum Sensing

Purine and glycine metabolism by purinolytic clostridia

Mechanisms of Toxicity of Adenosine, 2’-Deoxyadenosine, and Inhibitors of Adenosine Deaminase

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