Inhibition of microRNA let‐7b expression by KDM2B promotes cancer progression by targeting EZH2 in ovarian cancer

Ke, Ya; Xu, Hong; Lu, Fangfang; Meng, Jiahua; Yi, Yeye; Yang, Haowen; Hou, Hairui; Wu, Hao; Su, Shanheng

doi:10.1111/cas.14708

Cited by 21 publications

(16 citation statements)

References 31 publications

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“…Let -7b is a known tumor suppressor in breast, gastric and ovarian cancers [76][77][78]. In 2016, Zhen Huang and his team discovered that the administration of let-7b in tumor cells can repolarize M2 TAMs to M1, reverse the suppressive tumor microenvironment and inhibit tumor growth in a breast cancer mouse model [14], consistent with the tumor suppressive signature displayed by let-7b in our TRM panel.…”

Section: Discussionsupporting

confidence: 73%

An Eleven-microRNA Signature Related to Tumor-Associated Macrophages Predicts Prognosis of Breast Cancer

Jayasingam

Citartan

Zin

et al. 2022

IJMS

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The dysregulation of microRNAs (miRNAs) has been known to play important roles in tumor development and progression. However, the understanding of the involvement of miRNAs in regulating tumor-associated macrophages (TAMs) and how these TAM-related miRNAs (TRMs) modulate cancer progression is still in its infancy. This study aims to explore the prognostic value of TRMs in breast cancer via the construction of a novel TRM signature. Potential TRMs were identified from the literature, and their prognostic value was evaluated using 1063 cases in The Cancer Genome Atlas Breast Cancer database. The TRM signature was further validated in the external Gene Expression Omnibus GSE22220 dataset. Gene sets enrichment analyses were performed to gain insight into the biological functions of this TRM signature. An eleven-TRM signature consisting of mir-21, mir-24-2, mir-125a, mir-221, mir-22, mir-501, mir-365b, mir-660, mir-146a, let-7b and mir-31 was constructed. This signature significantly differentiated the high-risk group from the low-risk in terms of overall survival (OS)/ distant-relapse free survival (DRFS) (p value < 0.001). The prognostic value of the signature was further enhanced by incorporating other independent prognostic factors in a nomogram-based prediction model, yielding the highest AUC of 0.79 (95% CI: 0.72–0.86) at 5-year OS. Enrichment analyses confirmed that the differentially expressed genes were mainly involved in immune-related pathways such as adaptive immune response, humoral immune response and Th1 and Th2 cell differentiation. This eleven-TRM signature has great potential as a prognostic factor for breast cancer patients besides unravelling the dysregulated immune pathways in high-risk breast cancer.

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Section: Discussionsupporting

confidence: 73%

An Eleven-microRNA Signature Related to Tumor-Associated Macrophages Predicts Prognosis of Breast Cancer

Jayasingam

Citartan

Zin

et al. 2022

IJMS

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“…KDM2B has been reported to be an oncogene in a variety of human cancers 9–17 . It promotes disease progression in pancreatic cancer and ovarian cancer, and its expression levels were positively correlated to poor patient prognosis in gliomas and breast cancers 18–21 . Based on these findings, we speculated that KDM2B was also correlated to HSA malignancy like other human cancers.…”

Section: Patient No Gender Age (Years) Breed Primary Site Metastasis ...mentioning

confidence: 74%

“…[9][10][11][12][13][14][15][16][17] It promotes disease progression in pancreatic cancer and ovarian cancer, and its expression levels were positively correlated to poor patient prognosis in gliomas and breast cancers. [18][19][20][21] Based on these findings, we speculated that KDM2B was also correlated to HSA malignancy like other human cancers. Therefore, in this study, we aimed to investigate the relationships between KDM2B expression levels and disease progression or patients' prognosis in HSA.…”

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confidence: 99%

The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression

Gulay

Aoshima

Kim

et al. 2021

Vet Comparative Oncology

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Canine hemangiosarcoma (HSA), a highly fatal mesenchymal tumour of dogs, originates from the endothelial cells lining of blood vessels. It is characterized by a short survival time with a mean survival time of only 4 months. Recently, we showed that histone lysine demethylase 2B (KDM2B) was highly expressed in canine HSA and was important in HSA tumour cell survival by positively regulating DNA repair mechanisms. KDM2B has been reported to be related to disease progression and patient survival in several human cancers. Thus, in this study, we studied the relationship of KDM2B expression levels with several patient clinical profiles to investigate the role of KDM2B in clinical HSA tumours. We analysed 37 canine HSA cases and found that KDM2B is highly expressed in stage 3 HSA compared to stage 1 HSA. High KDM2B expression was also found in male dogs compared to female dogs. No correlation was observed between KDM2B expression and age. Classifying HSA patients into high and low KDM2B expression groups revealed that the high KDM2B group showed shorter overall survival than the low KDM2B group. Based on these results, we suggest that KDM2B expression is associated with disease progression in HSA.

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“…Специфичность паттерна эпигенетической регуляции при развитии патологий [12,13] может обеспечиваться через модуляцию спектра ББВ и посттрансляционные модификации, что также верно и в отношении CXXC-белков, которые принимают непосредственное участие в данном биологическом процессе. Поэтому исследования интерактома CXXC-белков как совокупного спектра взаимодействующих друг с другом индивидуальных белков и белковых комплексов важны с точки зрения получения новых знаний о: а) прямых и непрямых белковых партнёрах, формирующих мультибелковые комплексы; б) модифицирующих белках, таких как протеинкиназы и убиквитиназы; в) "каркасных" белках (от англ.…”

Section: Introductionunclassified

Interactomics of CXXC proteins involved in epigenetic regulation of gene expression

et al. 2022

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Regulation of gene expression is an extremely complex and multicomponent biological phenomenon. Proteins containing the CXXC-domain “zinc fingers” (CXXC-proteins) are master regulators of expression of many genes and have conserved functions of methylation of DNA bases and histone proteins. CXXC proteins function as a part of multiprotein complexes, which indicates the fundamental importance of studying post-translational regulation through modulation of the protein-protein interaction spectrum (PPI) in both normal and pathological conditions. In this paper we discuss general aspects of the involvement of CXXC proteins and their protein partners in neoplastic processes, both from the literature data and our own studies. Special attention is paid to recent data on the particular interactomics of the CFP1 protein encoded by the CXXC1 gene located on the human chromosome 18. CFP1 is devoid of enzymatic activity and implements epigenetic regulation of expression through binding to chromatin and a certain spectrum of PPIs.

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Inhibition of microRNA let‐7b expression by KDM2B promotes cancer progression by targeting EZH2 in ovarian cancer

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 21 publications

References 31 publications

An Eleven-microRNA Signature Related to Tumor-Associated Macrophages Predicts Prognosis of Breast Cancer

An Eleven-microRNA Signature Related to Tumor-Associated Macrophages Predicts Prognosis of Breast Cancer

The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression

Interactomics of CXXC proteins involved in epigenetic regulation of gene expression

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