2018
DOI: 10.1089/ars.2017.7005
|View full text |Cite
|
Sign up to set email alerts
|

Inhibition of miR-92a Suppresses Oxidative Stress and Improves Endothelial Function by Upregulating Heme Oxygenase-1 in db/db Mice

Abstract: MiR-92a expression is elevated in diabetic ECs. MiR-92a overexpression impairs endothelial function and suppresses HO-1 expression in ECs. Inhibition of miR-92a attenuates oxidative stress and improves endothelial function through enhancing HO-1 expression and activity in db/db mouse aortas. Antioxid. Redox Signal. 28, 358-370.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
46
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 67 publications
(46 citation statements)
references
References 53 publications
0
46
0
Order By: Relevance
“…Endothelial cell apoptosis under oxidative stress plays a critical role in the initiation and progression of atherosclerosis [131][132][133][134][135][136][137][138][139][140][141]. Li et al observed that overexpression of miRNA-210 caused inhibition of apoptosis and reduction of ROS level in human umbilical vein endothelial cells (HUVECs) treated with H 2 O 2 and also downregulation of caspase levels.…”
Section: Coronary Artery Diseases (Cad)mentioning
confidence: 99%
See 1 more Smart Citation
“…Endothelial cell apoptosis under oxidative stress plays a critical role in the initiation and progression of atherosclerosis [131][132][133][134][135][136][137][138][139][140][141]. Li et al observed that overexpression of miRNA-210 caused inhibition of apoptosis and reduction of ROS level in human umbilical vein endothelial cells (HUVECs) treated with H 2 O 2 and also downregulation of caspase levels.…”
Section: Coronary Artery Diseases (Cad)mentioning
confidence: 99%
“…MiRNA-92a overexpression impairs endothelial function and suppresses HO-1 expression in endothelial cells. Inhibition of miRNA-92a attenuates oxidative stress and improves endothelial function through enhancing HO-1 expression and activity in diabetic mouse aortas [138]. Yamac et al observed markedly lowered expression of miRNA-199a in patients with coronary artery disease [139].…”
Section: Coronary Artery Diseases (Cad)mentioning
confidence: 99%
“…Inhibition of miR-92a can hinder oxidative stress, inflammation, and apoptosis but promote angiogenesis [19]. This inhibition effect attenuates oxidative stress and improves endothelial function by enhancing HO-1 expression [20]. In addition, p38 MAPK/NF-κB is an ROS-sensitive signaling pathway, and an increase in ROS can promote endothelial cell apoptosis and activate inflammation, leading to thrombosis [21,22].…”
Section: Introductionmentioning
confidence: 99%
“…Increase of survived MSCs leads to the accumulation of secreted factors at the wound site, and thus is beneficial for the effect of MSC‐based therapy. HO‐1 is a critical factor for cell survival . Previous reports demonstrated that HO‐1 upregulation could inhibit the apoptosis of MSCs after transplantation in treating acute liver failure, irreversible intestinal failure, and retina ischemia/reperfusion injury , while lack of HO‐1 increased cellular damage caused by oxidative stress, leading to an enhanced apoptosis rate .…”
Section: Discussionmentioning
confidence: 99%