Inhibition of MT-450 rat mammary tumour growth by antibodies recognising subtypes of blood group antigen B

Sleeman, Jonathan; Kim, Untae; LePendu, Jacques; Howells, Norma; Coquerelle, Thérèse; Ponta, Helmut; Herrlich, Peter

doi:10.1038/sj.onc.1202808

Cited by 22 publications

(19 citation statements)

References 39 publications

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“…of Pathology, Nijmegen, The Netherlands); MAT-Lu and AT-2.1, rat prostate carcinoma (Isaacs et al, 1986); AR42J and ARIP, rat pancreas carcinoma (ATCC); RG2, rat glioblastoma (ATCC); BDX2, rat ®brosarcoma (Sleeman et al, 1996); and MT-450, rat breast adenocarcinoma (Kim, 1986;Sleeman et al, 1999).…”

Section: Cell Linesmentioning

confidence: 99%

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Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis

et al. 2002

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Hyperforin is a plant derived antibiotic from St. John's wort. Here we describe a novel activity of hyperforin, namely its ability to inhibit the growth of tumour cells by induction of apoptosis. Hyperforin inhibited the growth of various human and rat tumour cell lines in vivo, with IC 50 values between 3 ± 15 mM. Treatment of tumour cells with hyperforin resulted in a dose-dependent generation of apoptotic oligonucleosomes, typical DNA-laddering and apoptosis-speci®c morphological changes. In MT-450 mammary carcinoma cells hyperforin increased the activity of caspase-9 and caspase-3, and hyperforin-mediated apoptosis was blocked by the broad-range caspase inhibitor zVAD.fmk. When added to MT-450 cells, hyperforin, but not paclitaxel, induced a rapid loss of the mitochondrial transmembrane potential Dc m , and subsequent morphological changes such as homogenization and vacuolization of mitochondria. Monitoring of Dc m revealed that the hyperforin-mediated mitochondrial permeability transition can not be prevented by zVAD.fmk. This indicates that mitochondrial permeabilization is a cause rather than a consequence of caspase activation. Moreover, hyperforin was capable of releasing cytochrome c from isolated mitochondria. These ®ndings suggest that hyperforin activates a mitochondria-mediated apoptosis pathway. In vivo, hyperforin inhibited the growth of autologous MT-450 breast carcinoma in immunocompetent Wistar rats to a similar extent as the cytotoxic drug paclitaxel, without any signs of acute toxicity. Owing to the combination of signi®cant antitumour activity, low toxicity in vivo and natural abundance of the compound, hyperforin holds the promise of being an interesting novel antineoplastic agent that deserves further laboratory and in vivo exploration.

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Section: Cell Linesmentioning

confidence: 99%

“…Daily injections of the drugs/ control were administered subcutaneously at the site of the tumour cell injection for two weeks. Tumours were measured with a micrometre calliper every third day throughout the study (Sleeman et al, 1999). Studies with laboratory animals were approved by the local Ethical Review Board.…”

Section: Tumour Growth In Vivomentioning

confidence: 99%

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis

et al. 2002

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“…Other recent studies have reported the association between blood groups O and A individuals with increased incidence of duodenal ulcers and gastric carcinoma [7,8] as well as, the association of B group type and pancreatic cancer, Hodgkin's lymphomas and cardiac cancer [9][10][11]. Therefore, blood group antigens on the surface of cancer cells can be used as useful prognostic and diagnostic markers in different types of human cancers [12,13]. Blood group A is associated with increased risk of various tumors, including neurologic tumors, salivary gland, colon, uterus, ovary, pancreas, kidney, bladder and cervix [14].…”

Section: Introductionmentioning

confidence: 99%

Association of ABO Blood Group and Risk of Breast Cancer

Aly¹,

Yousef²

2014

J Blood Disord Transfus

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“…Many reports have shown that blood group antigen expression in tumor is correlated with metastasis [33,34] and prognosis [35,36] . The loss or presence of blood group antigens can increase cellular motility or facilitate the interaction between tumor cells and the endothelium of distant organs [37,38] .…”

Section: Discussionmentioning

confidence: 99%

Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China

Su¹,

Lu²,

Tian³

et al. 2001

WJG

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AIM To study the relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China, which is a unique Littoral high-risk area of esophageal carcinoma in China. The poor communication and transportation in the past has made Chaoshan a relatively closed area and kept its culture and custure of old China thousand years ago.METHODS Data on age, sex, ABO blood type and X-ray or patholog ical diagnose of the patients with carcinoma of esophagus or cardia were collected from the Tumor Hospital. First Affiliated Hospital, Second Affiliated Hospital of Shantou University Medical College; and the Central Hospital of Shantou and the Central Hospital of Jieyang. A total of 6685 patients with esophageal carcinoma (EC) and 2955 patients with cardiac cancer (CC) in Chaoshan district were retrospectively assessed for their association with ABO blood groups. RESULTSThe distribution of ABO blood groups in patients with EC or CC was similar to the normal local population in Chaoshan. However, blood group B in male patients with CC and in the patients with carcinoma in the upper third esophagus was 2.3% and 4.7% higher than the corresponding controls. The relative risk B:O was 1.1415 (P<0.05) and 1.2696 (P<0.05), respectively. No relationship was found between ABO blood groups and tumor differentiation.CONCLUSION ABO blood group B is associated with the incidence of CC in male individuals and carcinoma in the upper third esophagus. The distri bution of ABO blood groups varies in the different geographical and ethnic groups. As a result, proper controls are very important for such studies.

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Inhibition of MT-450 rat mammary tumour growth by antibodies recognising subtypes of blood group antigen B

Cited by 22 publications

References 39 publications

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis

Association of ABO Blood Group and Risk of Breast Cancer

Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China

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