Inhibition of Na pumps enhances Ca-dependent release of vasopressin from the isolated neurohypophysis of the rat.

Sorimachi, Masaru

doi:10.2170/jjphysiol.33.1061

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…T. increase in Ca*+ entry is insufficient to explain the reduced rate of S. Whgingham, and J. Williams (1984) Rahamimoff et al, 1980;Sorimachi, 1983). Cooling has Cooke, W. J., and J. D. (Nicoll and Alger, 1981b;Lancaster and Wheal, 1984; 895.…”

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Temperature dependence of intrinsic membrane properties and synaptic potentials in hippocampal CA1 neurons in vitro

Thompson¹,

Masukawa²,

Prince³

1985

J. Neurosci.

277

172

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The temperature dependence of intrinsic membrane conductances and synaptic potentials in guinea pig hippocampal CA1 pyramidal neurons were examined in vitro as they were cooled from 37°C to between 33 and 27%. Cooling reversibly increased resting input resistance in a voltage-independent manner (Go = 0.58 to 0.75). The amplitude and duration of orthodromically evoked action potentials were increased by cooling (Cl0 = 0.87 and 0.52 to 0.53, respectively), whereas the maximum rates of rise and fall were reduced (Q,,, =

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mentioning

confidence: 99%

Temperature dependence of intrinsic membrane properties and synaptic potentials in hippocampal CA1 neurons in vitro

Thompson¹,

Masukawa²,

Prince³

1985

J. Neurosci.

277

172

View full text Add to dashboard Cite

show abstract

Chapter 7 Intracellular Ionic Chanaes and Cell Activation: Regulation of DNA, RNA, and Protein Synthesis

Geering

1986

Current Topics in Membranes and Transport

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Sodium/Calcium Exchange: Its Physiological Implications

Blaustein

Lederer

1999

Physiological Reviews

1,560

1,549

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The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ pump. As a reversible transporter, it also mediates Ca2+ entry in parallel with various ion channels. The energy for net Ca2+ transport by the Na+/Ca2+ exchanger and its direction depend on the Na+, Ca2+, and K+ gradients across the PM, the membrane potential, and the transport stoichiometry. In most cells, three Na+ are exchanged for one Ca2+. In vertebrate photoreceptors, some neurons, and certain other cells, K+ is transported in the same direction as Ca2+, with a coupling ratio of four Na+ to one Ca2+ plus one K+. The exchanger kinetics are affected by nontransported Ca2+, Na+, protons, ATP, and diverse other modulators. Five genes that code for the exchangers have been identified in mammals: three in the Na+/Ca2+ exchanger family (NCX1, NCX2, and NCX3) and two in the Na+/Ca2+ plus K+ family (NCKX1 and NCKX2). Genes homologous to NCX1 have been identified in frog, squid, lobster, and Drosophila. In mammals, alternatively spliced variants of NCX1 have been identified; dominant expression of these variants is cell type specific, which suggests that the variations are involved in targeting and/or functional differences. In cardiac myocytes, and probably other cell types, the exchanger serves a housekeeping role by maintaining a low intracellular Ca2+ concentration; its possible role in cardiac excitation-contraction coupling is controversial. Cellular increases in Na+ concentration lead to increases in Ca2+ concentration mediated by the Na+/Ca2+ exchanger; this is important in the therapeutic action of cardiotonic steroids like digitalis. Similarly, alterations of Na+ and Ca2+ apparently modulate basolateral K+ conductance in some epithelia, signaling in some special sense organs (e.g., photoreceptors and olfactory receptors) and Ca2+-dependent secretion in neurons and in many secretory cells. The juxtaposition of PM and sarco(endo)plasmic reticulum membranes may permit the PM Na+/Ca2+ exchanger to regulate sarco(endo)plasmic reticulum Ca2+ stores and influence cellular Ca2+ signaling.

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Inhibition of Na pumps enhances Ca-dependent release of vasopressin from the isolated neurohypophysis of the rat.

Cited by 3 publications

References 20 publications

Temperature dependence of intrinsic membrane properties and synaptic potentials in hippocampal CA1 neurons in vitro

Temperature dependence of intrinsic membrane properties and synaptic potentials in hippocampal CA1 neurons in vitro

Chapter 7 Intracellular Ionic Chanaes and Cell Activation: Regulation of DNA, RNA, and Protein Synthesis

Sodium/Calcium Exchange: Its Physiological Implications

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