Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain

Wilar, Gofarana; Anggadiredja, Kusnandar; Shinoda, Yasuharu; Fukunaga, Kohji

doi:10.1159/000492154

Cited by 6 publications

(7 citation statements)

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“…AChE is the primary neurotransmitter in the nervous system of animals and functions by hydrolyzing Ach 5 . In this study, AChE activity was significantly increased by tobacco extract in adult male P. canaliculata , and a similar phenomenon has been observed in rats, which may be related to the increase in ACh receptor ligands under nicotine stimulation 43 , 46 . ACh may be hydrolysed faster by excessive AChE activity 5 , and ACh receptor occupancy by nicotine results in improper ACh conduction 9 , leading to nervous dysfunction and blocked muscle movement, which might contribute to snail death 5 .…”

Section: Discussionsupporting

confidence: 84%

“…Various antioxidant enzyme and AChE activity responses in the hepatopancreas have been observed under tobacco extract. Nicotine promotes reactive oxygen species (ROS) generation in a dose-dependent manner 43 , and SOD and CAT are dedicated to removing damaging ROS and are considered the first line of defence against lipid peroxidation and oxidative stress 44 , 45 . We found that SOD activity was increased by tobacco extract in medium and adult male snails, while a marked increase in CAT activity only occurred in adult males.…”

Section: Discussionmentioning

confidence: 99%

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Molluscicidal activity of Nicotiana tabacum extracts on the invasive snail Pomacea canaliculata

Guo

Zhang

Zeng

et al. 2023

Sci Rep

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Botanical molluscicides for controlling the invasive snail Pomacea canaliculata have attracted worldwide attention because of their cost and environmental friendliness. Aqueous extracts from discarded tobacco leaf (Nicotiana tobacum) were evaluated for molluscicidal activity against different-sized P. canaliculata under laboratory conditions. The results showed that over 90% of the snails died in 1 g/L tobacco extract within 4 days, and the survival of P. canaliculata was inversely proportional to the snail size, tobacco extract concentration and length of exposure time. Adult males were more susceptible to tobacco extract than females. The snails had few chances to feed or mate in 0.5 g/L tobacco extract, and reproduction was greatly limited in 0.2 g/L. The growth of juvenile snails was inhibited in 0.2 g/L tobacco extract, but adults were unaffected. The antioxidant capacity of P. canaliculata in response to tobacco extract can be size- and sex-dependent, and the activities of superoxide dismutase, catalase, and acetylcholinesterase and the contents of glutathione and malondialdehyde were increased in adult males. These results suggest that discarded tobacco leaves can be useful as a molluscicide for controlling the invasive snail P. canaliculata based on its effects on survival, behaviour, food intake, growth performance and antioxidant capacity.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Molluscicidal activity of Nicotiana tabacum extracts on the invasive snail Pomacea canaliculata

Guo

Zhang

Zeng

et al. 2023

Sci Rep

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“…Describing any genetic influence on smoking behavior would improve understanding of the etiology of tobacco dependence and potentially influence tobacco cessation strategies 17 . Previous studies support the relation between the cholinergic system and tobacco/nicotine dependence [18][19][20][21] . Choline acetyltransferase is an enzyme encoded by the ChAT gene and is responsible for synthesis of acetyl choline 22 .…”

Section: Introductionmentioning

confidence: 63%

The effect of genetic variations in the choline acetyltransferase gene (ChAT) on waterpipe tobacco smoking dependence

Khabour¹,

Abu-Eitah²,

Alzoubi³

et al. 2020

Tob. Induc. Dis.

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INTRODUCTION Waterpipe tobacco smoking (WS) is a popular form of tobacco use, globally. While the impact of genetic variations on smoking behavior has been well-investigated, few studies have examined this issue with regard to WS. In the current study, associations between choline acetyltransferase gene (ChAT) rs1917810 and rs7094248 polymorphisms and WS dependence were examined. METHODS Genotyping of rs1917810 and rs7094248 in 266 Jordanian waterpipe smokers was performed using RFLP-PCR. Dependence on WS was measured using the LWDS-10J scale. RESULTS The frequency of rs1917810 G allele was 38.5% and that of the rs7094248 G allele was 40.8%. The rs1917810 was significantly associated with the WS dependence level (p<0.05). Carriers of the AA genotype of rs1917810 were more dependent on WS than those with GG genotype (p<0.05). However, no association between rs7094248 single-nucleotide polymorphism (SNP) and dependence on WS was observed (p>0.05). CONCLUSIONS The rs1917810 in the ChAT gene might be associated with dependence on WS.

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“…Wilar et al [102] found that curcumin, AB10, and AB14 significantly suppressed the priming effects of nicotine and inhibited AChE activity (Figure 1).…”

Section: Inhibition Of Achementioning

confidence: 92%

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids

Chainoglou

Hadjipavlou‐Litina

2020

IJMS

109

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Worldwide, Alzheimer’s disease (AD) is the most common neurodegenerative multifactorial disease influencing the elderly population. Nowadays, several medications, among them curcumin, are used in the treatment of AD. Curcumin, which is the principal component of Curcuma longa, has shown favorable effects forsignificantly preventing or treating AD. During the last decade, the scientific community has focused their research on the optimization of therapeutic properties and on the improvement of pharmacokinetic properties of curcumin. This review summarizes bibliographical data from 2009 to 2019 on curcumin analogues, derivatives, and hybrids, as well as their therapeutic, preventic, and diagnostic applications in AD. Recent advances in the field have revealed that the phenolic hydroxyl group could contribute to the anti-amyloidogenic activity. Phenyl methoxy groups seem to contribute to the suppression of amyloid-β peptide (Aβ42) and to the suppression of amyloid precursor protein (APP) andhydrophobic interactions have also revealed a growing role. Furthermore, flexible moieties, at the linker, are crucial for the inhibition of Aβ aggregation. The inhibitory activity of derivatives is increased with the expansion of the aromatic rings. The promising role of curcumin-based compounds in diagnostic imaging is highlighted. The keto-enol tautomerism seems to be a novel modification for the design of amyloid-binding agents. Molecular docking results, (Q)SAR, as well as in vitro and in vivo tests highlight the structures and chemical moieties that are correlated with specific activity. As a result, the knowledge gained from the existing research should lead to the design and synthesis ofinnovative and multitargetedcurcumin analogues, derivatives, or curcumin hybrids, which would be very useful drug and tools in medicine for both diagnosis and treatment of AD.

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Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain

Cited by 6 publications

References 50 publications

Molluscicidal activity of Nicotiana tabacum extracts on the invasive snail Pomacea canaliculata

Molluscicidal activity of Nicotiana tabacum extracts on the invasive snail Pomacea canaliculata

The effect of genetic variations in the choline acetyltransferase gene (ChAT) on waterpipe tobacco smoking dependence

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids

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