Inhibition of Nursing-Induced and Stress-Induced Fall in Pituitary Prolactin Concentration in Lactating Rats by Injection of Acid Extracts of Bovine Hypothalamus

Grosvenor, Clark E.; McCANN, S. M.; Nallar, R

doi:10.1210/endo-76-5-883

Cited by 58 publications

(18 citation statements)

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“…A prolactin release to mild stress was not unexpected since Grosvenor, McCann and Naller [10] reported a fall in pituitary prolactin and Roth and Rosenblatt [17] an increase in mammary development in rats after mild stress. The later is of interest since it may be inferred that the prolactin released is biologically effective and the response in prolactin secretion to stress is a rational response.…”

Section: Discussionmentioning

confidence: 93%

Plasma Prolactin in Goats Measured by Radioimmunoassay: The Effects of Teat Stimulation, Mating Behavior, Stress, Fasting and of Oxytocin, Insulin and Glucose Injections

Bryant¹,

Linzell²,

Greenwood³

1970

Horm Res Paediatr

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Results are reported of measuring prolactin in goatplasma by a radioimmunoassay.Changes in concentration in plasma prolactin over time scales from minutes to hours were noted in animals not subject to experimental stimuli. It is presumed that these changes reflect the rapid removal of prolactin from plasma (t ½ 19 min) and the secretion of prolactin in response to unknown internal stimuli. Stimuli are reported which cause rises in plasma concentration suggestive of bursts of secretion from the pituitary. Copulation, in both males and females, sexual excitement in males and milking caused the largest increases in plasma concentration. Oxytocin injections and mild stress caused significant but smaller increases in plasma prolactin sometimes seen as a rise in jugular vein concentrations only. Plasma prolactin fell on fasting and after insulin and it rose on refeeding, but there was not a direct correlation with changes in blood glucose concentration.

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Section: Discussionmentioning

confidence: 93%

Plasma Prolactin in Goats Measured by Radioimmunoassay: The Effects of Teat Stimulation, Mating Behavior, Stress, Fasting and of Oxytocin, Insulin and Glucose Injections

Bryant¹,

Linzell²,

Greenwood³

1970

Horm Res Paediatr

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“…If this failure of the pituitary to produce or release sufficient lth to convert the corpus luteum of ovulation into a corpus luteum of pregnancy (Eckstein, 1962;Browning, 1962) and so cause a progesterone deficiency, is responsible for the death of the tubai ova, then it is reasonable to expect that the supplementation with progesterone of the mice fasted after mating would raise the fertility to normal. Progesterone had this effect (Table 3) (Meites, Nicoli & Talwalker, 1963;Grosvenor, McCann & Nallar, 1965).…”

Section: Experimental Methods and Resultsmentioning

confidence: 98%

Infertility in Mice Caused by Fasting at About the Time of Mating

McClure¹

1967

Reproduction

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Summary. Experiments designed to find the pathogenesis of the infertility caused by fasting mice for 18 to 48 hr at about the time of mating showed that: (a) within 4 hr of removal of all food the blood-glucose level fell to about half, and that this fall was delayed for about 24 hr by adding glucose to the drinking water; (b) protamine zinc insulin reduced both blood-glucose level and littering rate; (c) 2-deoxy-d-glucose (2dg) inhibited ovulation and caused the death of tubal ova; (d) fasting, insulin and 2dg appeared to cause similar effects upon the fertility; and (e) the expected infertility of fasted mice was prevented by the administration of human chorionic gonadotrophin and progesterone at the appropriate times.The evidence suggested that the primary biochemical disturbance was hypoglycaemia and that this inhibited adenohypophysial gonadotrophic function.

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“…It was also suggested that stress of handling and venipuncture might elevate the plasma prolactin level in the sheep or the goat ). An acute depletion of prolactin content in the pituitary of rat after laparotomy with bleeding or cervical stunning followed by decapitation was reported by Grosvenor et al(1965). Several noxious stimuli can induce a rapid and short-lived increase of simian growth hormone concentration in plasma (Meyer and Knobil, 1967).…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Plasma Prolactin Level in the Cow and the Goat as Determined by Radioimmunoassay

Johke

1970

Endocrinol Japon

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Inhibition of Nursing-Induced and Stress-Induced Fall in Pituitary Prolactin Concentration in Lactating Rats by Injection of Acid Extracts of Bovine Hypothalamus

Cited by 58 publications

References 0 publications

Plasma Prolactin in Goats Measured by Radioimmunoassay: The Effects of Teat Stimulation, Mating Behavior, Stress, Fasting and of Oxytocin, Insulin and Glucose Injections

Plasma Prolactin in Goats Measured by Radioimmunoassay: The Effects of Teat Stimulation, Mating Behavior, Stress, Fasting and of Oxytocin, Insulin and Glucose Injections

Infertility in Mice Caused by Fasting at About the Time of Mating

Factors Affecting the Plasma Prolactin Level in the Cow and the Goat as Determined by Radioimmunoassay

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