2005
DOI: 10.1038/sj.cgt.7700899
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Inhibition of ovarian cancer metastasis by adeno-associated virus-mediated gene transfer of nm23H1 in an orthotopic implantation model

Abstract: Ovarian cancer is one of the most threatening malignant tumors in females due to the frequent occurrence of metastasis that precedes diagnosis. The present study explored the possibility of preventing ovarian cancer metastasis by promoting nm23H1 expression through adeno-associated virus (AAV)-mediated gene transfer. A cell line of high metastatic potential, SW626-M4, was derived by in vivo selection and used to establish an ovarian cancer metastasis model in the mouse. Liver metastasis and animal survival tim… Show more

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Cited by 39 publications
(30 citation statements)
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“…Using AAV gene therapy vector, an Nm23-H1 construct was delivered into an ovarian carcinoma model of peritoneal metastasis. It was expressed by the tumor cells and significantly extended mouse survival (Li et al, 2006). The metastasis suppressive effects of Nm23-H1 were confirmed when Lacombe and colleagues developed an Nm23 knockout mouse.…”
Section: 3539 Targeting Tumor Metastasis By Regulating Nm23 Gene Expmentioning
confidence: 92%
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“…Using AAV gene therapy vector, an Nm23-H1 construct was delivered into an ovarian carcinoma model of peritoneal metastasis. It was expressed by the tumor cells and significantly extended mouse survival (Li et al, 2006). The metastasis suppressive effects of Nm23-H1 were confirmed when Lacombe and colleagues developed an Nm23 knockout mouse.…”
Section: 3539 Targeting Tumor Metastasis By Regulating Nm23 Gene Expmentioning
confidence: 92%
“…The expression of Nm23-H1 gene can be used to determine response treatment following radiotherapy for nasopharyngeal carcinomas and in ovarian cancer (Kapoor, 2009). Transfer of Nm23-H1 gene through adeno virus to prevent metastasis can be a rapid emerging and an improved version in therapeutic tool (Li et al, 2006;Kapoor, 2009). Modulating in Nm23-H1 gene expression can be used to draw to meet metastasis in malignant tumor because tumor metastasis is the leading cause of death in cancer patients (Marshall et al, 2009).…”
Section: Nm23: Novel Drug Targetmentioning
confidence: 99%
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“…Welch propose l'injection de Kisspeptines pour inhiber la colonisation métastatique [20]. Il a été montré que l'injection intra-péri-tonéale d'un vecteur adénoviral exprimant NM23-H1 réduit l'incidence des métastases hépatiques d'un modèle orthotopique de cancer de l'ovaire [40]. Très récemment, une équipe japonaise rapporte que l'administration intra-trachéale d'un vecteur adénoviral exprimant KAI1 réduit de façon majeure la masse des métastases ganglionnaires d'un modèle orthotopique de cancer du poumon [41].…”
Section: Ré-exprimer Les Gènes Suppresseurs De Métastases : Un Défi Tunclassified
“…An inhibition of the Nme enzymatic activity by small molecule inhibitors was initially intended, but the available polyphenols such as ellagic acid (Buxton 2008), although widely discussed to be beneficial in cancer therapy, are unspecific kinase inhibitors and show low potency. Gene therapy approaches were successful preclinically (Li et al 2006;Li et al 2009) but remain clinically intractable. A variety of alternative approaches have been pursued.…”
Section: Translational Advances In Cancer Therapy Based On Targeting mentioning
confidence: 99%