Inhibition of ovulation in rats by antagonists to serotonin and by a new tricyclic compound

Abstract

The ovulation inhibiting activity in adult rats of the 5HT-antagonists cyproheptadine, mianserin and methysergide is shown. Furthermore the activity of a newly synthetized Cycloheptathiophenederivative, compound 26-921, which inhibits LH-secretion and consequently ovulation, is described.

The Role of Serotonin and Dopamine in Hypothalamic‐pituitary Function

“…Serotonin antagonists such as LSD and methysergide inhibit PMS-induced ovulation in mice (Brown, 1967). Similarly, blockade of LH secretion and ovulation in spontaneously ovulating adult rats occurs with the administration of non-ergot serotonin antagonists (Marko & Fluckiger, 1976). These results, taken together with those of Hery et al (1976) suggest that, given the appropriate steroid environment, the predominant role of serotonin in LH release is a stimulatory one.…”

Role of Serotonin in the Regulation of Ovulation

“…This action was assumed to be due to 5-HT receptor blockade at one step in the hypothalamic events that con trol preovulatory LH release [13].…”