Inhibition of Oxidative Stress: An Important Molecular Mechanism of Chinese Herbal Medicine (Astragalus membranaceus, Carthamus tinctorius L., Radix Salvia Miltiorrhizae, etc.) in the Treatment of Ischemic Stroke by Regulating the Antioxidant System

Zhao, Xixi; Zhang, Yangyang; Wan, Haofang; Yang, Jiehong

doi:10.1155/2022/1425369

Cited by 23 publications

(12 citation statements)

References 87 publications

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“…[ 80 – 82 ] In a study, synthesized surface-modified Astragalus Polysaccharides were synthesized and loaded onto selenium nanoparticles containing Tanshinone IIA. [ 83 ] The study improved the bioavailability of both components. [ 84 ] It fully exerted its antioxidant capabilities, inhibiting the production of ROS, providing a new method for antioxidant therapy for spinal cord injury.…”

Section: Discussionmentioning

confidence: 99%

Research progress of Traditional Chinese Medicine (TCM) in targeting inflammation and lipid metabolism disorder for arteriosclerosis intervention: A review

et al. 2023

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Atherosclerosis (AS) is a chronic disease caused by inflammation and lipid deposition. Immune cells are extensively activated in the lesions, producing excessive pro-inflammatory cytokines, which accompany the entire pathological process of AS. In addition, the accumulation of lipid-mediated lipoproteins under the arterial intima is a crucial event in the development of AS, leading to vascular inflammation. Improving lipid metabolism disorders and inhibiting inflammatory reactions are the primary treatment methods currently used in medical practice to delay AS progression. With the development of traditional Chinese medicine (TCM), more mechanisms of action of the monomer of TCM, Chinese patent medicine, and compound prescription have been studied and explored. Research has shown that some Chinese medicines can participate in treating AS by targeting and improving lipid metabolism disorders and inhibiting inflammatory reactions. This review explores the research on Chinese herbal monomers, compound Chinese medicines, and formulae that improve lipid metabolism disorders and inhibit inflammatory reactions to provide new supplements for treating AS.

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Section: Discussionmentioning

confidence: 99%

Research progress of Traditional Chinese Medicine (TCM) in targeting inflammation and lipid metabolism disorder for arteriosclerosis intervention: A review

et al. 2023

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“…Safflower promotes blood circulation, removes stasis, relieves pain, and detoxifies blood. Salvia miltiorrhiza and safflower are essential medicines for promoting blood circulation and removing blood stasis (Orgah et al, 2020;Zhao et al, 2022). The main components of safflower are flavonoids, which are classified as quinoid chalcones, represented by hydroxysafflor yellow A, and common flavonoids, represented by kaempferol.…”

Section: Single Tcm Extract Injectionmentioning

confidence: 99%

Chinese herbal injection for cardio-cerebrovascular disease: Overview and challenges

et al. 2023

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Cardio-cerebrovascular diseases are the leading cause of death worldwide and there is currently no optimal treatment plan. Chinese herbal medicine injection (CHI) is obtained by combining traditional Chinese medicine (TCM) theory and modern production technology. It retains some characteristics of TCM while adding injection characteristics. CHI has played an important role in the treatment of critical diseases, especially cardio-cerebrovascular diseases, and has shown unique therapeutic advantages. TCMs that promote blood circulation and remove blood stasis, such as Salvia miltiorrhiza, Carthami flos, Panax notoginseng, and Chuanxiong rhizoma, account for a large proportion of CHIs of cardio-cerebrovascular disease. CHI is used to treat cardio-cerebrovascular diseases and has potential pharmacological activities such as anti-platelet aggregation, anti-inflammatory, anti-fibrosis, and anti-apoptosis. However, CHIs have changed the traditional method of administering TCMs, and the drugs directly enter the bloodstream, which may produce new pharmacological effects or adverse reactions. This article summarizes the clinical application, pharmacological effects, and mechanism of action of different varieties of CHIs commonly used in the treatment of cardio-cerebrovascular diseases, analyzes the causes of adverse reactions, and proposes suggestions for rational drug use and pharmaceutical care methods to provide a reference for the rational application of CHIs for cardio-cerebrovascular diseases.

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“…Currently, studies on oxidative stress and AS focus on two topics; the first is the role of oxidative stress in the pathological process of AS, analyzing how oxidative stress is involved in AS ( Yin et al, 2022 ) and the second is whether oxidative stress can be effectively targeted as a treatment for AS, specifically to slow down its progression, through clinical trials ( Smolyaninov et al, 2022 ; Xu et al, 2022 ; Zhao et al, 2022 ). The purpose of this study was to examine the association between oxidative stress-related genes and AS at the gene level, as well as to construct a diagnostic model and to investigate its immune microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Identification of oxidative stress-related genes and potential mechanisms in atherosclerosis

Tang

Deng²,

Luo³

et al. 2023

Front. Genet.

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Atherosclerosis (AS) is the main cause of death in individuals with cardiovascular and cerebrovascular diseases. A growing body of evidence suggests that oxidative stress plays an essential role in Atherosclerosis pathology. The aim of this study was to determine genetic mechanisms associated with Atherosclerosis and oxidative stress, as well as to construct a diagnostic model and to investigate its immune microenvironment. Seventeen oxidative stress-related genes were identified. A four-gene diagnostic model was constructed using the least absolute shrinkage and selection operator (LASSO) algorithm based on these 17 genes. The area under the Receiver Operating Characteristic (ROC) curve (AUC) was 0.967. Based on the GO analysis, cell-substrate adherens junction and focal adhesion were the most enriched terms. KEGG analysis revealed that these overlapping genes were enriched in pathways associated with Alzheimer’s disease and Parkinson’s disease, as well as with prion disease pathways and ribosomes. Immune cell infiltration correlation analysis showed that the immune cells with significant differences were CD4 memory activated T cells and follicular helper T cells in the GSE43292 dataset and CD4 naïve T cells and CD4 memory resting T cells in the GSE57691 dataset. We identified 17 hub genes that were closely associated with oxidative stress in AS and constructed a four-gene (aldehyde dehydrogenase six family member A1 (ALDH6A1), eukaryotic elongation factor 2 kinase (EEF2K), glutaredoxin (GLRX) and l-lactate dehydrogenase B (LDHB)) diagnostic model with good accuracy. The four-gene diagnostic model was also found to have good discriminatory efficacy for the immune cell infiltration microenvironment of AS. Overall, these findings provide valuable information and directions for future research into Atherosclerosis diagnosis and aid in the discovery of biological mechanisms underlying AS with oxidative stress.

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Inhibition of Oxidative Stress: An Important Molecular Mechanism of Chinese Herbal Medicine (Astragalus membranaceus, Carthamus tinctorius L., Radix Salvia Miltiorrhizae, etc.) in the Treatment of Ischemic Stroke by Regulating the Antioxidant System

Cited by 23 publications

References 87 publications

Research progress of Traditional Chinese Medicine (TCM) in targeting inflammation and lipid metabolism disorder for arteriosclerosis intervention: A review

Research progress of Traditional Chinese Medicine (TCM) in targeting inflammation and lipid metabolism disorder for arteriosclerosis intervention: A review

Chinese herbal injection for cardio-cerebrovascular disease: Overview and challenges

Identification of oxidative stress-related genes and potential mechanisms in atherosclerosis

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