1972
DOI: 10.1136/gut.13.5.361
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Inhibition of pancreatic secretion in man by cigarette smoking

Abstract: SUMMARY Cigarette smoking has been linked to an elevated incidence of duodenal ulcer disease in smokers, although the mechanism is unclear. In 23 young normal subjects single or double secretin tests were performed during non-smoking and smoking periods. Cigarette smoking inhibited the secretion of pancreatic juice and bicarbonate in light smokers ( < one pack/day for < three years). Heavy smokers ( > one pack/day for > three years) exhibited depressed pancreatic secretory rates during non-smoking periods. Inh… Show more

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Cited by 93 publications
(28 citation statements)
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“…Since these alterations are known as early events in the development of acute experimental pancreatitis, cigarette smoke might contribute to an acute exacerbation of alcoholic chronic pancreatitis [24]. Since tobacco smoking inhibited pancreatic bicarbonate secretion in humans [25] and reduced both serum trypsin inhibitory capacity and alpha-1 antitrypsin levels [26], this experimental model provided further evidence that smoking should be considered an independent risk factor for the development of chronic pancreatitis [27].…”
Section: Effects Of Acute Alcohol Administration In Combination With mentioning
confidence: 90%
“…Since these alterations are known as early events in the development of acute experimental pancreatitis, cigarette smoke might contribute to an acute exacerbation of alcoholic chronic pancreatitis [24]. Since tobacco smoking inhibited pancreatic bicarbonate secretion in humans [25] and reduced both serum trypsin inhibitory capacity and alpha-1 antitrypsin levels [26], this experimental model provided further evidence that smoking should be considered an independent risk factor for the development of chronic pancreatitis [27].…”
Section: Effects Of Acute Alcohol Administration In Combination With mentioning
confidence: 90%
“…Thus, smoking not only exhibits regulatory effects on pancreatic acinar cells but also influences ductal cell function. This has been demonstrated by the examination of pancreatic bicarbonate secretion, where in humans bicarbonate secretion was reduced upon cigarette smoke inhalation in a time-dependent manner [58][59][60]. However, in these cells, carcinogenic events are unlikely to be mediated by a disturbance of the physiologic regulation.…”
Section: Inflammation Alters Regulation Of Ductal Genesmentioning
confidence: 99%
“…Smoking has been demonstrated to cause inhibition of pancreatic secretion [14] and increased leakage of pancreatic zymogens into the bloodstream [15] . Increased intracellular content of pancreatic zymogens and vacuolization of acinar cells have been demonstrated in the rat after chronic exposure to nicotine [16][17][18] .…”
Section: Introductionmentioning
confidence: 99%