Inhibition of Photodegradation of Highly Dispersed Folic Acid Nanoparticles by the Antioxidant Effect of Transglycosylated Rutin

Abstract

We developed highly dispersible and photostable nanoparticles of vitamin, folic acid (FA). FA was wet bead milled with milling and dispersing adjuvants and transglycosylated compounds such as α-glucosyl hesperidin (Hesperidin-G) and rutin (Rutin-G), which solubilized FA. The milled slurries of FA particles with transglycosylated compounds consisted of nanosized particles with a median diameter of <100 nm. The lyophilized formulations of these slurries retained their nanometer size after resuspension in water with no aggregation. The apparent solubility of FA in these formulations was 100-fold higher than that of untreated FA. The solubilizing effect of Rutin-G may affect the particle size reduction and dispersibility of FA. The photostability results showed that the strong antioxidant activity of Rutin-G substantially increased the photostability of FA solution. On the basis of these results, bead milling of FA with Rutin-G is a promising technique for developing highly dispersible, photostable nanoparticle FA formulations.

Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones

“…Hesperidin activated PPARγ in diabetic rat and caused a reduction in blood lipid peroxide levels [88]. Glucosyl-hesperidin, which is formed by intestinal α-glycosidase, also has radical trapping capacity [89]. It has been shown to reduce blood triglyceride levels and improve abnormal LDL metabolism [90,91,92].…”

Preparation of a Highly Water-dispersible Powder Containing Hydrophobic Polyphenols Derived from Chrysanthemum Flower with Xanthine Oxidase-inhibitory Activity

“…activity The DPPH activity of stevia-G, rutin-G, hesperidin-G, and ascorbic acid was measured to evaluate antioxidant activity as reported elsewhere (Chen et al, 2013;Kadota et al, 2016c). The prepared 2 mL of a 0.1 mM solution of DPPH in ethanol was mixed with each sample solution of 2 mL at different concentrations as follows: stevia-G, rutin-G, and hesperidin-G ranged from 0.65 to 65 mM, and ascorbic acid as a reference ranged from 2.8 to 280 mM.…”

Grafting Thin Layered Graphene Oxide onto the Surface of Nonwoven/PVDF-PAA Composite Membrane for Efficient Dye and Macromolecule Separations

“…The molecular weight and molecular structure of different dyes (Rh-B and MO), folic acid (FA) and protein (BSA) are listed in Table 1. The feed volume was 1 L DI water containing feed solutions of 10 ppm dye solutions (typical dye concentration in synthetic dye wastewater or treated real textile effluent [41,42]) or 500 ppm of FA or BSA solutions (typical concentration in fermented vegetable solution containing FA [43] and BSA composition in whey [44]). The permeance values at steady state were calculated and continuously analyzed at 20-min intervals.…”