Inhibition of Prostaglandin E2 and Leukotriene C4 in Mouse Peritoneal Macrophages and Thromboxane B2 Production in Human Platelets by Flavonoids from Stachys chrysantha and Stachys candida.

Skaltsa, Helen; Bermejo, Paulina; Lazari, Diamanto; Silván, A. M.; Skaltsounis, Alexios‐Léandros; Sanz, Aurora; Abad, María J. F.

doi:10.1248/bpb.23.47

Cited by 47 publications

(19 citation statements)

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“…From the methanol (MeOH) extract of the aerial parts of the plant, six acylated flavone glycosides (1-6; Fig. 1) (Albach, Grayer, Jensen, Özgökçe, & Veitch, 2003;Lenherr & Mabry, 1987;Rios et al, 1992;Rodriguez-Lyon, Diaz-Lanza, Bernabe, & Villaescusa-Castillo, 2000;Skaltsa, Bermejo, Lazari, & Silvan, 2000) and one phenylethanoid glycoside (7) (Sticher & Lahloub, 1982) were isolated. The 7-O-glycosides of 8-OH-flavones (hypolaetin, isoscutellarein, and their methyl ethers) (1-6) isolated in this study are known, as they occur in another species of Sideritis and Stachys (Lamiaceae) and Veronica species (Scrophulariaceae) (Rios et al, 1992;Albach et al, 2003;Rodriguez-Lyon et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Investigations of anti-inflammatory, antinociceptive, antioxidant and aldose reductase inhibitory activities of phenolic compounds from Sideritis brevibracteata

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Investigations of anti-inflammatory, antinociceptive, antioxidant and aldose reductase inhibitory activities of phenolic compounds from Sideritis brevibracteata

et al. 2010

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“…Many Stachys species are used in folk medicine. 1 In recent years phytochemical investigations on different taxa of this genus have been intensified, showing that extracts or components of Stachys species exert various pharmacological effects: anti-inflammatory, antitoxic, hypoazotemic, antihepatitis, antibacterial [2][3][4] and antioxidant. 5 S. alpina L. belongs to the polymorphic S. germanica L. complex.…”

Section: Introductionmentioning

confidence: 99%

Composition of essential oil of Stachys alpina L. ssp. dinarica Murb.

Kukić¹,

Petrović²,

Pavlović³

et al. 2006

Flavour & Fragrance J

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Essential oils of aerial parts of Stachys alpina ssp. dinarica collected from two localities in Bosnia and Herzegovina (Mt Jahorina and Mt Maglic, respectively) were investigated. Essential oils were obtained by hydrodistilation and analyzed using GC and GC-MS. Essential oil yields were 0.03 and 0.05% (w/w), respectively, and in each oil 71 components were identified, comprising 87.2 and 89.3% of the total amount. The main components in both samples were (E)-caryophyllene (13.4 and 9.3%), germacrene D (12.3 and 5.5%), caryophyllene oxide (5.7 and 8.4%), (E)-nerolidol (4.8 and 5.6%), n-nonanal (5.3 and 5.0%) and linalool (1.7 and 5.7%, respectively).

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“…Moreover, it has also been reported that chrysoeriol directly scavenges the superoxide radicals generated by xanthine and the xanthine oxidase system [4]. In addition, a series of in vitro studies have demonstrated that it relaxes smooth muscle, reduces obesity, and controls the immune system [5][6][7][8][9]. However, the mechanistic bases of these pharmacological activities have not been explored.…”

Section: Introductionmentioning

confidence: 99%

Chrysoeriol potently inhibits the induction of nitric oxide synthase by blocking AP-1 activation

et al. 2005

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Chrysoeriol is a flavonoid with antioxidant and anti-inflammatory activities. Despite the large number of studies performed on its biological activities, no clear picture of its mode of action has emerged. In the present study, we isolated chrysoeriol from the leaves of Digitalis purpurea (foxglove), and studied its effect on the induction of the inducible nitric oxide synthase (iNOS) gene, and the mechanism of this induction in Raw264.7 macrophages. Chrysoeriol pretreatment potently inhibited the release of NO in the cells treated with lipopolysaccharide (LPS), and Western blot and RT-PCR analyses revealed that chrysoeriol inhibited the LPS-induced inductions of iNOS gene. Moreover, it is known that the activations of nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) are crucial steps in the transcriptional activation of the iNOS gene. Here, we found that chrysoeriol selectively suppressed AP-1 activation, and that activation of AP-1 is likely to be essential for iNOS induction in LPS-treated macrophages. This presumed inhibitory effect on AP-1 activation by chrysoeriol may be associated with its potent NO blocking and anti-inflammatory effects.

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Inhibition of Prostaglandin E2 and Leukotriene C4 in Mouse Peritoneal Macrophages and Thromboxane B2 Production in Human Platelets by Flavonoids from Stachys chrysantha and Stachys candida.

Cited by 47 publications

References 1 publication

Investigations of anti-inflammatory, antinociceptive, antioxidant and aldose reductase inhibitory activities of phenolic compounds from Sideritis brevibracteata

Investigations of anti-inflammatory, antinociceptive, antioxidant and aldose reductase inhibitory activities of phenolic compounds from Sideritis brevibracteata

Composition of essential oil of Stachys alpina L. ssp. dinarica Murb.

Chrysoeriol potently inhibits the induction of nitric oxide synthase by blocking AP-1 activation

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