2006
DOI: 10.1016/j.exer.2005.09.004
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Inhibition of retinal neovascularization by soluble EphA2 receptor

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Cited by 65 publications
(49 citation statements)
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“…We previously reported that VEGF stimulation of endothelial cells leads to up-regulated expression of ephrin-A1 within the endothelium (17,34), and blockade of EphA-class receptor activation can inhibit several VEGF-mediated angiogenic processes, including migration, assembly, sprouting, survival, and corneal/ retinal angiogenesis (34,42). These data suggest that autocrine ephrin-A1 plays an important role in angiogenic responses of endothelial cells to proangiogenic signals.…”
Section: Ephrin-a1 In Angiogenesis and Metastasismentioning
confidence: 86%
“…We previously reported that VEGF stimulation of endothelial cells leads to up-regulated expression of ephrin-A1 within the endothelium (17,34), and blockade of EphA-class receptor activation can inhibit several VEGF-mediated angiogenic processes, including migration, assembly, sprouting, survival, and corneal/ retinal angiogenesis (34,42). These data suggest that autocrine ephrin-A1 plays an important role in angiogenic responses of endothelial cells to proangiogenic signals.…”
Section: Ephrin-a1 In Angiogenesis and Metastasismentioning
confidence: 86%
“…It causes less effusion than cryotherapy and has at least as good results from an anatomical and visual standpoint (10)(11)(12) . In the not so distant future, it may be that pharmacologic therapy will be possible (7,(13)(14)(15)(16) . Besides the immediate short-term results it seems that laser therapy may also be beneficial in respect to longterm functional and visual outcome.…”
Section: Discussionmentioning
confidence: 99%
“…The siRNA suppressed three-dimensional tubular formation on basement membrane extracts in a timedependent manner, and blocked angiogenesis in mice implanted with subcutaneous Matrigel plugs. Moreover, a single intravitreal administration of the siRNA suppressed retinal neovascularisation in mice subjected to the hyperoxia-induced retinopathy of prematurity model, which has been used to evaluate the anti-angiogenic properties of several compounds including VEGF antisense oligonucleotides (Robinson et al, 1996), Macugen/EYE-001 (Eyetech, 2002), combretastatin-A4 (Griggs et al, 2002) and soluble EphA2 receptor (Chen et al, 2006). TGF␤, coadministered with the siRNA, increased retinal vascularity, which was abrogated by cis-9-octadecenoyl-N-hydroxylamide, consistent with the involvement of a metalloproteinase such as MMP-2 (Aye et al, 2004;Emonard et al, 1999;Liao et al, 2003).…”
Section: Discussionmentioning
confidence: 99%