Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis

Barthomeuf, Chantal; Lamy, Sylvie; Blanchette, Mélanie; Boivin, Dominique; Gingras, Denis; Béliveau, Richard

doi:10.1016/j.freeradbiomed.2005.09.015

Cited by 34 publications

(19 citation statements)

References 35 publications

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“…SGE both prevents and inhibits angiogenesis in the Matrigel model, decreases the basal motility of endothelial and cancer cells, and reverses the chemotactic effect of angiogenic factors [83].…”

Section: Effect On Paf-metabolism; a New Approach?mentioning

confidence: 93%

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The Implication of Platelet Activating Factor in Cancer Growth and Metastasis: Potent Beneficial Role of PAF-Inhibitors and Antioxidants

Τσούπρας¹,

Iatrou

Frangia

et al. 2009

IDDT

145

169

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Cancer is one of the leading causes of death in Europe and United States. New blood vessel formation penetrating into solid tumors seems to be required for their growth and metastasis. Several protein growth factors can induce endothelial cell proliferation and angiogenesis, through signal transduction cascades that result in the production of several inflammatory mediators and lipid second messengers such as prostaglandins and Platelet Activating Factor (PAF). PAF is a potent mediator of inflammation that is implicated in several inflammatory pathological conditions such as atherosclerosis, cardiovascular and renal diseases, allergy, AIDS, cancer etc. It exerts its biological activities through G-protein-coupled receptors. The presence of PAF in the microenvironment of tumors may be due to its synthesis from circulating and / or cancer cells. Moreover, cancer cells and activated endothelial cells expose PAF-receptor on their membrane surface. PAF binding on its receptor induces several pathways that result in the onset and development of tumor induced angiogenesis and metastasis. PAF-receptor antagonists have exhibited promising results in vitro and in vivo as anti-angiogenic molecules in several cancer cells and tumors. A dietary profile reach in antioxidants and PAF-inhibitors (such as the Mediterranean Diet) may provide beneficial preventive and protective effects against development, growth and metastatic manifestations of cancer cells, through either their inhibition of PAF activity and / or its biosynthesis. The clarification of factors that may down regulate pathologically increased PAF-levels in a tumor microenvironment may also contribute to the planning of a potent nontoxic preventive and therapeutic approach against cancer.

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Section: Effect On Paf-metabolism; a New Approach?mentioning

confidence: 93%

“…Several of these antioxidants have exhibited anti-cancer potential through their general anti-PAF activities [37,83,84].…”

Section: Web-2086mentioning

confidence: 99%

The Implication of Platelet Activating Factor in Cancer Growth and Metastasis: Potent Beneficial Role of PAF-Inhibitors and Antioxidants

Τσούπρας¹,

Iatrou

Frangia

et al. 2009

IDDT

145

169

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“…However, a recent study that followed 783 elderly individuals who regularly consumed diets rich in resveratrol has found no significant association between any health benefits and total urinary resveratrol metabolite, casting doubts on its healthpromoting effects (Semba et al 2014). It is important to note that red wine (Guebailia et al 2006) and other diets (Baechler et al 2014;Barthomeuf et al 2006) also contain significant amount of resveratrol oligomers that might be responsible for some of the beneficial health effects.…”

Section: Resveratrol Monomersmentioning

confidence: 99%

“…For example, resveratrol abrogates tumor necrosis factor-induced activation of NF-κB within 30 min of treatment (Ashikawa et al 2002;Manna et al 2000). Moreover, pre-treatment of endothelial cells with SGE (a red grape skin polyphenolic extract, containing resveratrol oligomers) reduces the responsiveness of these cells to S1P-induced migration, ERK1/2 activation and platelet-activating factor synthesis (Barthomeuf et al 2006). NF-κB is a proposed downstream effector of S1P (Alvarez et al 2010).…”

Section: Cancer and Inflammationmentioning

confidence: 99%

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

et al. 2014

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Resveratrol, a natural compound endowed with multiple health-promoting effects, has received much attention given its potential for the treatment of cardiovascular, inflammatory, neurodegenerative, metabolic and age-related diseases. However, the translational potential of resveratrol has been limited by its specificity, poor bioavailability and uncertain toxicity. In recent years, there has been an accumulation of evidence demonstrating that resveratrol modulates sphingolipid metabolism. Moreover, resveratrol forms higher order oligomers that exhibit better selectivity and potency in modulating sphingolipid metabolism. This review evaluates the evidence supporting the modulation of sphingolipid metabolism and signaling as a mechanism of action underlying the therapeutic efficacy of resveratrol and oligomers in diseases, such as cancer.

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“…The phenolic radical is stabilized by the unsaturated 2,3-double bond of the side chain. 26 Some studies suggested that the anticancer ability of these compounds can also relate to the induction of apoptosis or inhibition of apoptosissuppressing proteins in various cancer cell lines, including breast cancer cells, and animal models. The para substitution and ortho substitution allow the phenoxy radical stabilization after the delocalization across the entire molecule, and therefore increases its antioxidative efficiency.…”

Section: Natural Occurring Caffeic and Ferulic Acids In Health And DImentioning

confidence: 99%

Caffeic and Ferulic Acid Derivatives

Serafim

Milhazes

Borges

et al. 2015

Coffee in Health and Disease Prevention

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Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis

Cited by 34 publications

References 35 publications

The Implication of Platelet Activating Factor in Cancer Growth and Metastasis: Potent Beneficial Role of PAF-Inhibitors and Antioxidants

The Implication of Platelet Activating Factor in Cancer Growth and Metastasis: Potent Beneficial Role of PAF-Inhibitors and Antioxidants

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

Caffeic and Ferulic Acid Derivatives

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