Inhibition of synaptic ATPases by heptachlorepoxide in rat brain

Yamaguchi, Isamu; Matsumura, Fumio; Kadous, A.A.

doi:10.1016/0048-3575(79)90068-3

Cited by 29 publications

(9 citation statements)

References 20 publications

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“…Neurotoxicant-induced derangement of calcium metabolism has often been inferred by alterations of 45 Ca transport or inhibition of mitochondrial ATPase [25,26], perhaps consequent to attack on critical sulfhydryl groups [27,28]. The availability and ease of application of this new technology by which [Ca 2 •1 can be assayed in metabolically active cells and synaptosomes, should allow a more direct evaluation of calcium levels in intracellular compartments.…”

Section: Resultsmentioning

confidence: 99%

Intracellular calcium as an index of neurotoxic damage

Bondy

Komulainen²

1988

Toxicology

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Section: Resultsmentioning

confidence: 99%

Intracellular calcium as an index of neurotoxic damage

Bondy

Komulainen²

1988

Toxicology

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“…[18] and liberated inorganic phosphate was estimated by adopting the method of Fiske and Subbarow. [19] Total protein concentration was measured following the method of Lowry et al .…”

Section: Methodsmentioning

confidence: 99%

Cold stress offered modulation on chlorpyrifos toxicity in aging rat central nervous system

Basha¹,

Poojary²

2012

Toxicol Int

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The adverse effects produced by chlorpyrifos (CPF) or cold stress alone in humans and animals are well documented, but there is no information available relating to the consequences of their co- exposure in an age-related manner. In this study, effects of sublethal doses of CPF were carried out in vivo, for 48 h to assess the biochemical perturbations in relation to interactions with cold stress (15°C and 20°C) in different age group rat CNS. A positive interaction of CPF with age of animal and cold exposure was observed resulting in marked decrease in the activity levels of AChE (P<0.05), ChAT (P<0.05), Na+, K+-ATPase (P<0.05), Ca2+-ATPase (P<0.05), and Mg2+-ATPase (P<0.05). The ANOVA and posthoc analysis showed that regulatory enzymes decreased significantly (P<0.05) on CPF exposure. Overall, the effect of co-exposure was appreciably different from either of the exposures. Synergistic interaction of CPF and cold stress at 15°C showed higher inhibition in comparison with CPF and cold stress alone and together at 20°C. Further, this study reveals that young animals are significantly vulnerable and sensitive than adults.

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“…AMY has suffered Ca 2+ -ATPase inhibition more at the earlier part of the experiment than the later period and the enzyme is found inhibited at 31.45% at the end of the experiment. Inhibition in the activity of Ca 2+ -ATPases increase the rate of transmitter release by increasing intracellular Ca 2+ in the presynaptic region (20). When the enzyme is inhibited, the efflux of calcium across the membrane may be decreased.…”

Section: Ca 2+ -Atpasementioning

confidence: 99%

Inhibition of ATPases Enzyme Activities on Brain Disturbing Normal Oestrous Cycle

Venugopal

Ramakrishna

2005

Neurochem Res

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Wistar rats treated with alpha-methyl-DL-p-tyrosine methylester showed significant level of inhibition in the activity of Na+, K+ -ATPase, Mg2+ -ATPase and Ca2+ -ATPase enzymes in different regions of the brain. The enzyme activity was assayed in cerebral hemispheres, hypothalamus, thalamus, hippocampus, amygdala and septum at proestrous (12 h), estrous (25 h), metestrous (38 h) and diestrous periods (92 h) of the rat. The Na+, K+ -ATPase activity was significantly inhibited in most of the brain regions after treated with alpha-methyl-DL-p-tyrosine methylester (MPT) and this indicated that MPT affected the active transport system and nerve impulse transmission. Mg2+ -ATPase and Ca2+ -ATPase was also significantly (P < 0.001) reduced in different regions of the brain. The results revealed that MPT affected active transport system and nerve impulse transmission by inhibiting Na+, K+ -ATPase and Ca2+ -ATPase. It has induced energy crisis by inhibiting Mg2+ -ATPase and all these cumulative effects of MPT have adversely affected the female Wistar rats. These effects have been manifested in the form of aberrations in the behavior of MPT treated female rats, which have shown their inability to perform their normal sexual activity.

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Inhibition of synaptic ATPases by heptachlorepoxide in rat brain

Cited by 29 publications

References 20 publications

Intracellular calcium as an index of neurotoxic damage

Intracellular calcium as an index of neurotoxic damage

Cold stress offered modulation on chlorpyrifos toxicity in aging rat central nervous system

Inhibition of ATPases Enzyme Activities on Brain Disturbing Normal Oestrous Cycle

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