Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells

Xia, Xiang

doi:10.3892/or_00000625

Cited by 34 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tetramethylpyrazine (TMP) is an alkaloid monomer isolated from Ligusticum chuanxiong hort (Chen et al, 2018). A series of studies have shown that TMP possesses a variety of antitumor effects including the inhibition of tumor cell proliferation, invasion, and drug resistance (Wang et al, 2010). Reports have demonstrated that TMP administration induces apoptosis and autophagy in hepatocellular carcinoma (Cao et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Tetramethylpyrazine Enhances the Antitumor Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis

Zou

Liu

et al. 2019

Front. Pharmacol.

View full text Add to dashboard Cite

Recent published findings have demonstrated the effectiveness of combining molecules from traditional Chinese medicine with chemotherapeutic drugs to treat cancer. Combined administration of these agents can overcome drug-mitigating responses as well as reduce adverse side effects, thereby enhancing the efficacy of the therapy. Tetramethylpyrazine (TMP), an alkaloid monomer from the medicinal herb Ligusticum chuanxiong hort, is known to exert a variety of antitumor effects including inhibition of tumor cell proliferation, metastasis, and drug resistance. In this research, we investigated antitumor effects of TMP combined with paclitaxel (PTX), a frontline chemotherapeutic drug, in vitro and in vivo . Our results indicate that TMP enhances the antitumor effects of PTX in ovarian cancer A2780 and SKOV3 cells. Furthermore, we found that combined treatment of TMP and PTX suppressed angiogenesis by inhibiting both ERK1/2 and Akt pathways and promoted apoptosis of tumor cells compared to TMP or PTX treatment alone. Moreover, TMP augmented the antitumor effects of PTX in ovarian cancer A2780 xenograft mouse models by significantly decreasing tumor burden and partially decreasing the toxicity of PTX, as evidenced by the decreased expression of proliferation and angiogenesis markers as well as the hematoxylin and eosin (H&E) staining and biochemical indexes assay. Overall, our findings provide novel mechanistic insight into the efficacy of combining of potent molecules present in traditional Chinese medicine with chemotherapeutic drugs for therapeutic intervention in cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Tetramethylpyrazine Enhances the Antitumor Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis

Zou

Liu

et al. 2019

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Ligustrazine induces the expression of the metabolizing enzyme CYP3A4 via PXR 454 . The mRNA and protein levels of MDR1, MRP2, MRP3 and MRP5 were decreased after treatment with ligustrazine 455 . In addition, senkyunolide G inhibited OAT1, OAT2 446 .…”

Section: Tcms For the Treatment Of Covid-19 Infectionsmentioning

confidence: 94%

Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine

Ye¹,

Fan²,

Zhao³

et al. 2023

Acta Pharmaceutica Sinica B

View full text Add to dashboard Cite

“…Glaucine not only functioned as inhibitor of transporters but also reduced the expression of MDR1 and MRP1 (Lei et al, 2013) while the isoquinoline alkaloids berberine and coptisine, mediated the expression of P-gp (Lin et al, 1999a). Tetramethylpyrazine downregulated the expression of MDR1, MRP2, MRP3 and MRP5 in BEL-7402/ADM cells (Wang et al, 2010). It has also reduced the expression of MDR1 and MRP1 in MCF-7/Dox and Pumc-91/ADM cells, respectively (Zhang et al, 2012;Wang et al, 2016).…”

Section: Phytochemicals Modulating Transporter or Protein Expressionmentioning

confidence: 99%

Phytochemicals: Potential Lead Molecules for MDR Reversal

2020

View full text Add to dashboard Cite

Multidrug resistance (MDR) is one of the main impediments in the treatment of cancers. MDR cancer cells are resistant to multiple anticancer drugs. One of the major mechanisms of MDR is the efflux of anticancer drugs by ABC transporters. Increased activity and overexpression of these transporters are important causes of drug efflux and, therefore, resistance to cancer chemotherapy. Overcoming MDR is a fundamental prerequisite for developing an efficient treatment of cancer. To date, various types of ABC transporter inhibitors have been employed but no effective anticancer drug is available at present, which can completely overcome MDR. Phytochemicals can reverse MDR in cancer cells via affecting the expression or activity of ABC transporters, and also through exerting synergistic interactions with anticancer drugs by addressing additional molecular targets. We have listed numerous phytochemicals which can affect the expression and activity of ABC transporters in MDR cancer cell lines. Phytochemicals in the groups of flavonoids, alkaloids, terpenes, carotenoids, stilbenoids, lignans, polyketides, and curcuminoids have been examined for MDR-reversing activity. The use of MDR-reversing phytochemicals with low toxicity to human in combination with effective anticancer agents may result in successful treatment of chemotherapy-resistant cancer. In this review, we summarize and discuss published evidence for natural products with MDR modulation abilities.

show abstract

Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells

Cited by 34 publications

References 20 publications

Tetramethylpyrazine Enhances the Antitumor Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis

Tetramethylpyrazine Enhances the Antitumor Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis

Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine

Phytochemicals: Potential Lead Molecules for MDR Reversal

Contact Info

Product

Resources

About