Inhibition of the angiotensin converting enzyme by venom of the scorpion Centruroides sculpturatus

Longenecker, Gesina L.; Longenecker, Herbert E.; Watt, Dean D.; Huggins, Charles; Peterson, Christian A.

doi:10.1016/0041-0101(80)90096-3

Cited by 6 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The action of aldosterone requires BK and ROMK uninhibited by most scorpion venom. Further complicated is the presence of angiotensin converting enzyme inhibitor in some scorpion species ( Centruroides sculpturatus , Buthus occitanus and Mesobuthus martensii ) which tends to increase serum K, and also natriuretic peptide in some species which increases K excretion through BK. The venom of Tityus serruratus has natriuretic peptides .…”

Section: Scorpion Envenoming and Renal K Transportmentioning

confidence: 99%

Animal toxins and renal ion transport: Another dimension in tropical nephrology

Sitprija

2016

Nephrology

View full text Add to dashboard Cite

Sitprija et al have reviewed the issue regarding renal vascular and renal tubular ion channels and transporters involved in animal toxin injury. Several vascular and renal tubular ion channels have been modulated by various animal toxins, resulting in hemodynamic alterations. ABSTRACT:Renal vascular and tubular ion channels and transporters involved in toxin injury are reviewed. Vascular ion channels modulated by animal toxins, which result in haemodynamic alterations and changes in blood pressure, include ENaC/Degenerin/ASIC, ATP sensitive K channels (KATP), Ca activated K channels (Kca) and voltage gated Ca channels, mostly L-type. Renal tubular Na channels and K channels are also targeted by animal toxins. NHE3 and ENaC are two important targets. NCC and NKCC may be involved indirectly by vasoactive mediators induced by inflammation. Most renal tubular K channels including voltage gated K channels (Kv1), KATP, ROMK1, BK and SK are blocked by scorpion toxins. Few are inhibited by bee, wasp and spider venoms. Due to small envenoming, incomplete block and several compensatory mechanisms in renal tubules, serum electrolyte charges are not apparent. Changes in serum electrolytes are observed in injury by large amount of venom when several channels or transporters are targeted. Envenomings by scorpions and bees are examples of toxins targeting multiple ion channels and transporters.

show abstract

Section: Scorpion Envenoming and Renal K Transportmentioning

confidence: 99%