1977
DOI: 10.1159/000214195
|View full text |Cite
|
Sign up to set email alerts
|

Inhibition of the Fibrinolytic System in Behçet’s Disease?

Abstract: Suppression of the fibrinolytic system is a well-known phenomenon in patients with Behçet’s disease. It is generally explained by an increase in the inhibitory potential. In order to prove this theory, the fibrinolytic system was investigated in 5 male patients with severe chronic Behçet’s disease. By the venous occlusion test, a marked suppression of the activatability of the system could be demonstrated (euglobulin lysis time, various fibrin plate assays). Results of analysis of the known inhibitors could no… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

3
3
0

Year Published

1980
1980
1999
1999

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 10 publications
(6 citation statements)
references
References 14 publications
3
3
0
Order By: Relevance
“…Previous work has indicated a defective fibrinolytic response in patients with Behcet's disease both to venous occlusion (8,10) and to DDAVP infusion (11) which it has been suggested might be part of a more extensive endothelial cell dysfunction (11). We did not examine the response to DDAVP infusion, but our results concur in suggesting that in Behcet's disease there is increased inhibition of plasma plasminogen activator activity.…”
Section: Discussionsupporting
confidence: 47%
See 1 more Smart Citation
“…Previous work has indicated a defective fibrinolytic response in patients with Behcet's disease both to venous occlusion (8,10) and to DDAVP infusion (11) which it has been suggested might be part of a more extensive endothelial cell dysfunction (11). We did not examine the response to DDAVP infusion, but our results concur in suggesting that in Behcet's disease there is increased inhibition of plasma plasminogen activator activity.…”
Section: Discussionsupporting
confidence: 47%
“…Extensive DVT and superficial thrombophlebitis are often features of conditions with an underlying pro-coagulant tendency, such as malignancy, antithrombin III or protein C deficiency (4). Abnormalities in coagulation have not been reported in Behcet's disease, though a reduction in plasma plasminogen activator activity has been found consistently (5)(6)(7)(8)(9). The mechanism may be either a defect in endothelial release of plasminogen activator(s) or the presence of an unidentified circulating inhibitor (9,10).…”
Section: Introductionmentioning
confidence: 99%
“…The results of the coagulation studies of our patients closely resemble those previously reported (Chajek et a1 1973a, Chajek & Fainaru 1973, Asbeck et al 1977, Stathakis et a1 1977. Features are: increased levels of fibrinogen and factor VIII and normal Values for factors V, VII, IX, and X, and antithrombin 111.…”
Section: Discussionsupporting
confidence: 91%
“…Reduced response to venous occlusion as reported recently for 5 Behget patients without thrombosis (Asbeck et al 1977) was found only in case 1. Extrinsic activator originates from endothelial cells and the reduced response in this test may be due to the vascular deterioration frequently seen in Behset's disease and which was most extensive in case 1.…”
Section: Discussionsupporting
confidence: 78%
“…The rationale of its use is based on the fact that non-specific vasculitis is one of the most common histological findings in Behfet's disease. Further reports of the efficacy of fibrinolytics in this condition followed (Kirk & Handley, 1972;Chajek & Fainaru, 1973;Cunliffe, Roberts & Dodman, 1973) and the claims for their beneficial activity were further supported by the demonstration of impaired fibrinolysis in some patients (Sobel, Tabori & Tatarski, 1974)-The exact mechanism of their action and the precise demonstration of any defect in or of an inhibitor of the clot dissolving mechanism has remained unanswered (Asbeck, Meyer-Boernecke & van de Loo, 1977). Furthermore, there have been no controlled studies with these drugs in Beh9et's disease.…”
Section: Discussionmentioning
confidence: 98%