Inhibition of the myotoxic and hemorrhagic activities of crotalid venoms by Eclipta prostrata (Asteraceae) extracts and constituents

Neutralization of edema, hemorrhage and myonecrosis induced by North American crotalid venoms in simulated first-aid treatments

“…These results are consistent with the previous studies by Ownby et al (1975), Melo et al (1993) and Melo et al (1994) and others working with non-crotalid venom, that also showed that mixing venom with various antagonists prior to injection provided greater neutralization of local tissue damage than when antagonist were given after injection of venom. In both the in vitro and in vivo experiments, antivenom tended to show an overall greater reduction of local tissue damage than p-BPB.…”

“…Melo et al (1994) investigated the ability of certain extracts from the plant, Eclipta prostrata, to neutralize myotoxic and hemorrhagic activity of Crotalid venoms. Melo and Suarez-Kurtz (1988) and Melo et al (1993) also showed the ability of heparin and other polyanions to inhibit crotalid venom action.…”

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex

“…9,10 Here, we demonstrated that wedelolactone has anti-inflammatory effect through inhibiting IKK activity and caspase-11 expression. Wedelolactone inhibited the secretion of the proinflammatory cytokine IL-1b, which maturated by caspase-11-activated caspase-1, from mouse splenocytes.…”

“…Eclipta prostrata L. is a herb medicine that has been used in the treatment of infective hepatitis in India, 9 snake venom poisoning in Brazil, 10 as well as septic shock in folk medicine in China. Since caspase-11 expression is highly sensitive to a variety of pathological stimuli and likely to be induced under these different pathological conditions, we tested the possibility that E. prostrata L. may contain an activity that can inhibit caspase-11 induction.…”

Neutralization of the edema-forming, defibrinating and coagulant effects of Bothrops asper venom by extracts of plants used by healers in Colombia

“…Some of them have been characterized as inhibitors of cyclooxygenase and lipoxygenase activities (24). Additionally, some plants active against the lethal effect of snake venoms (25,26, present study) are also active against the edema induced by venoms. The herbal compound (2-OH-4-methoxy benzoic acid) isolated from the root extract of Hemidesmus indicus R. BR effectively neutralized the inflammation induced by Vipera russelli venom in male albino mice and reduced the cotton pelletinduced granuloma in rats (27).…”