Inhibition of the Sodium-Retaining Influence of Aldosterone by Progesterone*†

Landau, Richard L.; Lugibihl, Kathleen

doi:10.1210/jcem-18-11-1237

Cited by 256 publications

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“…The higher sodium excretion before oestrus would be consistent with competitive inhibition of aldosterone by progesterone as proposed for humans by Landau & Lugibuhl (1958). One might, however, doubt such an explanation in sheep with daily aldosterone secretion rates and plasma concentrations which are much lower than in humans (Coghlan & Scoggins, 1967;Blair-West, Coghlan, Denton, Scott & Wright, 1968).…”

Section: Psupporting

confidence: 52%

Communications

1974

The Journal of Physiology

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When muscles shorten they produce heat faster than during isometric contraction. This extra heat production is the shortening heat (Hill, 1938). In a series of closely spaced tetanic contractions of frog sartorius muscle at O0 C, the shortening heat is less in the second and subsequent contractions than in the first. Fig. 1 A shows records of the heat rate during the first and second contractions of a series at 5 sec intervals. Fig. 1B shows how the average value of the shortening heat falls during such series, to 66 + 4 % (mean+ s.E.) of the initial value by the third contraction. By the 10th contraction the shortening heat was found to be only 15 + 18 % of the initial value (3 observations). The reduction in the shortening heat is less when the interval between the tetani is greater, and is hardly evident when this interval is 40 sec.The reduction in shortening heat might be due to previous activation, metabolic activity, or shortening. If either activation or metabolic activity were the cause, an isometric contraction should also reduce the shortening heat in subsequent contractions. The results in Fig. 1B show that this is not the case; thus it can be concluded that the reduction in shortening heat is a specific consequence of previous shortening.The isometric tension developed falls during a series of contractions but the tension exerted during shortening at speeds of 10, 20 and 30 mm/sec 98P

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Section: Psupporting

confidence: 52%

Communications

1974

The Journal of Physiology

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“…This natriuresis is further augmented by atrial natriuretic peptide, which increases significantly by week 12 of pregnancy (2) and was demonstrated to augment the fractional excretion of sodium when infused in late pregnancy (64). In addition, progesterone attenuates sodium reabsorption by competitively inhibiting aldosterone at the tubular mineralocorticoid receptor (65). Other factors that may promote natriuresis include decrements in serum albumin concentration and increments in prostaglandins and melanocyte stimulating hormone (66).…”

Section: Electrolyte Balancementioning

confidence: 99%

Obstetric Nephrology

Odutayo

Hladunewich

2012

Clinical Journal of the American Society of Nephrology

172

106

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SummaryGlomerular hyperfiltration, altered tubular function, and shifts in electrolyte-fluid balance are among the hallmark renal physiologic changes that characterize a healthy pregnancy. These adjustments are not only critical to maternal and fetal well being, but also provide the clinical context for identifying gestational aberrations in renal function and electrolyte composition. Systemic vasodilation characterizes early gestation and produces increments in renal plasma flow and GFR, the latter of which is maintained into the postpartum period. In addition, renal tubular changes allow for the accumulation of nutrients and electrolytes necessary for fetal growth such that wasting of proteins, glucose, and amino acids in urine is limited in pregnancy and total body stores of electrolytes increase throughout gestation. Substantial insight into the mechanisms underlying these complex adjustments can be gleaned from the available animal and human literature, but our understanding in many areas remains incomplete. This article reviews the available literature on renal adaptation to normal pregnancy, including renal function, tubular function, and electrolyte-fluid balance, along with the clinical ramifications of these adjustments, the limitations of the existing literature, and suggestions for future studies.

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“…During the part of the cycle between ovulation and the onset of menstruation (postovulatory phase), the concentration of progesterone is high. Progesterone reportedly has a natriuretic effect (Landau and Lugibihl, 1958) and the increase in progesterone after ovulation is thought to be followed by a compensatory rise in aldosterone concentration. Research concerning estradiol has focused predominantly on reproductive issues such as conception, ovulation, infertility and menopause (Lipson and Ellison, 1996).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Salivary Electrolytes during Normal Menstrual Cycle with Special Reference to Ovulation

Alagendran¹,

Archunan²,

Armando³

et al. 2010

American Journal of Applied Sciences

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Abstract:There is evidence to imply that estrogen influences salivary electrolytes activity in women. Problem statement: In this study we investigated changes in sodium, potassium and inorganic phosphorus, calcium and magnesium which related to find out the precise day of ovulation. These changes might help to explain the fluctuation of ovarian hormones such as preovulatory estrogen surge. Approach: Human whole saliva was collected from 48 healthy subjects of women (age range 20-30 years) during reproductive phases of menstrual cycle were assayed using atomic absorption spectrometer and enzyme immune assay. Amongst a range of electrolytes have been identified such as sodium, potassium, inorganic phosphorus and calcium were comparatively found to be higher during ovulatory phase when compared to that of other phases. Changes were attributed to a probable hormonal outcome on salivary composition. Results: Conversely, in other phases (preovulatory and postovulatory) electrolytes activity like magnesium and calcium decreased later, declining significantly (p<0.05). The increase of electrolytes like sodium and potassium in human saliva, during ovulatory phase might be due to the circulation of steroid hormones. Conclusion: Further, the presence of particular salts influence by ovarian hormones like LH and progesterone in ovulatory saliva makes the possibility to expand a sign for spotlight of ovulation by means of noninvasive method.

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Inhibition of the Sodium-Retaining Influence of Aldosterone by Progesterone*†

Cited by 256 publications

References 0 publications

Communications

Communications

Obstetric Nephrology

Evaluation of Salivary Electrolytes during Normal Menstrual Cycle with Special Reference to Ovulation

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