Inhibition of the Vesicular Glutamate Transporter (VGLUT) with Congo Red Analogs: New Binding Insights

Hitt, David M.; Zwicker, Jeffery D.; Chao, Chih‐Kai; Patel, Sarjubhai A.; Gerdes, John M.; Bridges, Richard J.; Thompson, Charles M.

doi:10.1007/s11064-020-03182-0

Cited by 2 publications

(2 citation statements)

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“…The process of glutamate entering synaptic vesicles through VGLUTs is mainly driven by Δψ 15 . Chloride ion (Cl − ) stimulation, which occurs on either side of the synaptic vesicle membrane, causes VGLUTs to transport glutamate into the synaptic vesicle 16 . Synaptic vesicles then fuse with the plasma membrane of neurons, releasing glutamate from the vesicles as a neurotransmitter into the synaptic cleft.…”

Section: Glutamate–glutamine Cyclementioning

confidence: 99%

“… 15 Chloride ion (Cl − ) stimulation, which occurs on either side of the synaptic vesicle membrane, causes VGLUTs to transport glutamate into the synaptic vesicle. 16 Synaptic vesicles then fuse with the plasma membrane of neurons, releasing glutamate from the vesicles as a neurotransmitter into the synaptic cleft. Following glutamate release, VGLUTs become localized on the plasma membrane.…”

Section: Glutamate–glutamine Cyclementioning

confidence: 99%

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The role of glutamate and glutamine metabolism and related transporters in nerve cells

Zhang,

Hua,

2024

CNS Neurosci Ther

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BackgroundGlutamate and glutamine are the most abundant amino acids in the blood and play a crucial role in cell survival in the nervous system. Various transporters found in cell and mitochondrial membranes, such as the solute carriers (SLCs) superfamily, are responsible for maintaining the balance of glutamate and glutamine in the synaptic cleft and within cells. This balance affects the metabolism of glutamate and glutamine as non‐essential amino acids.AimsThis review aims to provide an overview of the transporters and enzymes associated with glutamate and glutamine in neuronal cells.DiscussionWe delve into the function of glutamate and glutamine in the nervous system by discussing the transporters involved in the glutamate‐glutamine cycle and the key enzymes responsible for their mutual conversion. Additionally, we highlight the role of glutamate and glutamine as carbon and nitrogen donors, as well as their significance as precursors for the synthesis of reduced glutathione (GSH).ConclusionGlutamate and glutamine play a crucial role in the brain due to their special effects. It is essential to focus on understanding glutamate and glutamine metabolism to comprehend the physiological behavior of nerve cells and to treat nervous system disorders and cancer.

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Section: Glutamate–glutamine Cyclementioning

confidence: 99%

Section: Glutamate–glutamine Cyclementioning

confidence: 99%