2019
DOI: 10.1002/hed.25956
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Inhibition of tropomyosine receptor kinase B on the migration of human Schwann cell and dispersion of oral tongue squamous cell carcinoma in vitro

Abstract: Background Schwann cells (SC) may play an important role in perineural invasion (PNI) by promoting cancer cell dispersion. Brain‐derived neurotrophic factor (BDNF) may contribute to these cellular events by activating tropomyosine receptor kinase B (TrkB). This study examines the effect of TrkB inhibition on SC migration and oral cancer cell dispersion in vitro. Methods Human tongue squamous cell carcinoma (SCC‐9) and human SCs were cocultured in three different conditioned mediums: control, BDNF, and TrkB inh… Show more

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Cited by 7 publications
(4 citation statements)
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“…A great deal of the literature evidence shows an association of PNI with mortality and the risk of recurrence, but the different histopathological definitions of infiltration (surrounding at least 1–3 of the circumferences of the nerve or only touching it) could be the reason for the non-homogeneous evidence in the literature [ 103 , 104 , 105 ].…”
Section: Discussionmentioning
confidence: 99%
“…A great deal of the literature evidence shows an association of PNI with mortality and the risk of recurrence, but the different histopathological definitions of infiltration (surrounding at least 1–3 of the circumferences of the nerve or only touching it) could be the reason for the non-homogeneous evidence in the literature [ 103 , 104 , 105 ].…”
Section: Discussionmentioning
confidence: 99%
“…PNI is more likely a complex and dynamic process that relies on reciprocal signaling between the tumor and components of the nerve (e.g., Schwann cells and neurons). Recent evidence suggests that SCC can communicate with nerves long before physical contact between cell types occur [ 17 , 18 , 21 , 22 , 27 , 94 , 95 ]. Head and neck SCC may secrete neurotrophic factors into the local environment that are detected by Schwann cells and neurons.…”
Section: Potential Mechanisms Of Perineural Invasionmentioning
confidence: 99%
“…Once detected, Schwann cells and neurons can secrete other neurotrophic factors that lead to downstream events, promoting cancer cell invasion and neurite outgrowth. The interactions of secreted neurotrophins with their high affinity receptors between cancer and nerve is a new area of interest in the pathogenesis of PNI [ 8 , 21 , 22 , 96 ].…”
Section: Potential Mechanisms Of Perineural Invasionmentioning
confidence: 99%
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