Inhibition of Tumour Growth by D-Glucosamine

Quastel, J. H.; Cantero, Antonio

doi:10.1038/171252a0

Cited by 129 publications

(44 citation statements)

References 6 publications

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“…The substances used were D-glucosamine hydrochloride (Quastel and Cantero, 1953), 4-amino-N10-methyl pteroyl glutamic acid, 2:4:6-tris-ethylene-imino-l: 3: 5-triazine (triethylene melamine) (Hendry, Homer, Rose, and Walpole, 1951), Actinomycin C, 6-mercaptopurine and four dimethane sulphonyloxyalkanes CH3SO2O(CH2).OSO2CH3 (Haddow and Timmis, 1953Y Those tested were the compounds where n=3, 4, 6, and 8. The compound where n=4 is known as Myleran.…”

Section: Effect Of Other Compounds On Pregnancymentioning

confidence: 99%

The Action of Some Nucleotoxic Substances on Pregnancy

Didcock

Jackson

Robson

1956

British Journal of Pharmacology and Chemotherapy

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In a previous investigation (Didcock, Picard, and Robson, 1952) it was shown that podophyllotoxin, which is a nucleotoxic substance with striking inhibitory effects on certain tumours, will interrupt pregnancy in mice and rabbits. The relation between the dose necessary to affect pregnancy and that toxic and lethal to the mother-what might be called in this connexion the therapeutic ratio-was, however, low, being of the order of 4. It was of interest to investigate the effect of other nucleotoxic substances on pregnancy, to determine whether there is any relation between nucleotoxic activity and effect on pregnancy, and also whether there are any nucleotoxic substances with a higher therapeutic ratio than podophyllotoxin. METHODSThe experiments were performed on mice and rabbits. In the former the duration of pregnancy was dated from the finding of the vaginal plug, and in the latter from the observed mating. In mice injected between the sixth and tenth days of pregnancy a laparotomy was performed to establish that a normal pregnancy was present. After this time it is possible to confirm the existence of pregnancy by abdominal palpation. Before the sixth day, when implantation occurs, the effect of the drug was established by dividing a number of mice, in which vaginal plugs had been found, into two groups. One group was treated and the other served as control.The intra-amniotic and intraplacental injections were performed on rabbits under ether anaesthesia with full sterile precautions.

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Section: Effect Of Other Compounds On Pregnancymentioning

confidence: 99%

The Action of Some Nucleotoxic Substances on Pregnancy

Didcock

Jackson

Robson

1956

British Journal of Pharmacology and Chemotherapy

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“…Thus, glucosamine has been widely used to treat osteoarthritis in humans (Reginster et al, 2001). In addition to its chondroprotective action, glucosamine has been supposed to exert anticancer action more than five decades (Marlow and Bartlett, 1953;Quastel and Cantero, 1953;Fjelde et al, 1956;Sorkin and Fjelde, 1956;Ball et al, 1957;Luhrs, 1957;Kizer and Mc, 1959).…”

Section: Introductionmentioning

confidence: 99%

Glucosamine induces cell deathviaproteasome inhibition in human ALVA41 prostate cancer cell

Liu

Meng

et al. 2011

Exp Mol Med

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Glucosamine, a naturally occurring amino monosaccharide, has been reported to play a role in the regulation of apoptosis more than half century. However the effect of glucosamine on tumor cells and the involved molecular mechanisms have not been thoroughly investigated. Glucosamine enters the hexosamine biosynthetic pathway (HBP) downstream of the rate-limiting step catalyzed by the GFAT (glutamine:fluctose-6-phosphate amidotransferase), providing UDPGlcNAc substrates for O-linked β-N-acetylglucosamine (O-GlcNAc) protein modification. Considering that O-GlcNAc modification of proteasome subunits inhibits its activity, we examined whether glucosamine induces growth inhibition via affecting proteasomal activity. In the present study, we found glucosamine inhibited proteasomal activity and the proliferation of ALVA41 prostate cancer cells. The inhibition of proteasomal activity results in the accumulation of ubiquitinated proteins, followed by induction of apoptosis. In addition, we demonstrated that glucosamine downregulated proteasome activator PA28γ and overexpression of PA28γ rescued the proteasomal activity and growth inhibition mediated by glucosamine. We further demonstrated that inhibition of O-GlcNAc abrogated PA28γ suppression induced by glucosamine. These findings suggest that glucosamine may inhibit growth of ALVA41 cancer cells through downregulation of PA28γ and inhibition of proteasomal activity via O-GlcNAc modification.

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“…The inhibition effects of tumor growth by glucosamine and mannosamine have already been reported. [13][14][15][16] These effects were predicted to be caused by DHPs, because some DHPs are easily formed from these aminosugars in vitro. 17) It has also been reported that a dihydropyrazine (DHP) derivative, such as 3,6-dihydropyrazine-2,5-dipropanoic acid 17) derived from 5-aminolevulinic acid, caused an increased risk of liver cancer due to DNA damage.…”

mentioning

confidence: 99%

Generation of Radical Species from Dihydropyrazines Having DNA Strand-Breakage Activity and Other Characteristics

Yamaguchi

Matsumoto

Masumizu

et al. 2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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The various biological activity of dihydropyrazines(DHPs)due to the radical generation potency has been described in previous papers. Detailed data about radical species generating be mentioned here. The electron spin resonance (ESR) spin-trapping technique revealed that DHPs generate free radical species such as · OH, · OOH, · CHR 2 and · CR 3 . Oxygen radicals and two carbon-centered radicals were detected as adducts of the spin traps DMPO and DBNBS, respectively. All the 5,5-dimethyl-1-pyrroline-N-oxide (DMPO)-and 3,5-dibromo-4-nitrosobenzenesulfonate (DBNBS)-adducts of compounds DHP-1-8 exhibited approximately the same signal patterns, with various levels of intensity depending on the substituent of the dihydropyrazine ring. The ESR signal intensity of DHPs also increased remarkably upon addition of Cu 2 , resulting that the effects of DHPs were enhanced.

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Inhibition of Tumour Growth by D-Glucosamine

Cited by 129 publications

References 6 publications

The Action of Some Nucleotoxic Substances on Pregnancy

The Action of Some Nucleotoxic Substances on Pregnancy

Glucosamine induces cell deathviaproteasome inhibition in human ALVA41 prostate cancer cell

Generation of Radical Species from Dihydropyrazines Having DNA Strand-Breakage Activity and Other Characteristics

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