Inhibition of tyrosine hydroxylase by 3-iodo-L-tyrosine

Goldstein, Menek; Weiss, Zvi

doi:10.1016/0024-3205(65)90126-8

Cited by 25 publications

(4 citation statements)

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“…3-Iodo-L-tyrosine is a potent tyrosine hydroxylase inhibitor in vitro (GOLDSTEIN & WEISS 1965). Since inhibition of this enzyme may cause a decrease in catecholamine content of the brain in pheniprazine-treated mice also, we investigated the effect of 3-iodotyrosine on the pheniprazine counteraction of reserpine-induced inhibition of amine uptake.…”

Section: Ma 0-inhibitorsmentioning

confidence: 99%

In Vitro Inhibition of Noradrenaline‐³H Uptake by Reserpine and Tetrabenazine in Mouse Cerebral Cortex Tissues

Ross¹,

Renyi²

1966

Acta Pharmacologica et Toxicologica

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Section: Ma 0-inhibitorsmentioning

confidence: 99%

In Vitro Inhibition of Noradrenaline‐³H Uptake by Reserpine and Tetrabenazine in Mouse Cerebral Cortex Tissues

Ross¹,

Renyi²

1966

Acta Pharmacologica et Toxicologica

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“…DDC does not seem to be exerting a reserpine-like action in the present experiments because it depletes only noradrenaline whereas reserpine depletes dopamine, noradrenaline and 5-hydroxytryptamine from tissues; furthermore, the 5-hydroxytryptamine content after the injection of DDC remains unchanged and, of even greater significance, the dopamine level increases. Inhibition by 3-iodo-L-tyrosine of the enzyme tyrosine hydroxylase, the enzyme responsible for the ring-hydroxylation of tyrosine to form DOPA in the biosynthesis of noradrenaline, lowers both the dopamine and noradrenaline tissue contents (see also Udenfriend, ZaltzmanNirenberg & Nagatsu, 1965;Goldstein, Anagoste & Nakajima, 1965;Goldstein & Weiss, 1965). DDC (Goldstein et al, 1964) and disulfiram (Goldstein et al, 1964;Musacchio et a!., 1964;Musacchio et al, 1966), however, do not modify the uptake or the binding of noradrenaline, and disulfiram has been shown to be ineffective in releasing noradrenaline from rat hearts (Musacchio et al, 1966).…”

Section: Injections Of Diethyldithiocarbamatementioning

confidence: 99%

Some Pharmacological Actions of Diethyldithiocarbamate on Rabbit and Rat Ileum

Collins

West

1968

British Journal of Pharmacology and Chemotherapy

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“…3-iodo-Tyrosine (3IT), a competitive inhibitor of tyrosine hydroxylase (Goldstein & Weiss, 1965;Ikeda, Levitt& Udenfriend, 1965) at a dose of 200 mg/kg subcutaneously reduces brain levels of noradrenaline and dopamine. Sodium diethyldithiocarbamate (DDC) inhibits dopamine-f-hydroxylase (Goldstein, Anagoste, Lauber & McKereghan, 1964) and DDC (500 mg/kg subcutaneously) decreases noradrenaline levels to a greater degree than 3IT, while increasing dopamine content.…”

Section: Harrogatementioning

confidence: 99%

Proceedings of the British Pharmacological Society

1969

British J Pharmacology

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(HC3) is a derivative of diphenyl (Long & Schueler, 1954;Schueler, 1955), with high but somewhat variable toxicity. Death in small animals follows respiratory paralysis of delayed onset; this is usually explained as being the result of the inhibition of acetylcholine synthesis. There is evidence that HC3 can affect choline metabolism in other ways and has some actions which occur immediately after its administration (Gardiner, 1961;Domer & Gardiner, 1968). It is uncertain whether these other actions are involved in the lethal intoxication, so we are studying analogues of HC3 in which the balance between the various actions might be different. This communication reports some experiments with the p-terphenyl analogue (TPHC3) of HC3.The LD50 following intraperitoneal injection into mice was 95 ,ug/kg for HC3 and 80 ,ug/kg for TPHC3. These values were determined simultaneously with groups of mice from common stock; on other occasions the values varied between 150 and 50 ,tg/kg for either substance.Both HC3 (10-4M) and TPHC3 (10-4M) strongly inhibited the synthesis of acetylcholine by guinea-pig brain mince and with either the inhibition was less if choline (10-'M) was present.Inhibitory effects were produced by both substances on the responses of isolated tissues involving acetylcholine. The toad isolated rectus abdominis and the guineapig isolated ileum were immediately and reversibly depressed by concentrations greater than 106M; the spontaneous activity of rabbit jejunum was more resistant, being affected when the concentration of HC3 or TPHC3 was raised to 104M.Either substance (0.5 mg/kg intravenously) in chicks produced an immediate curare-like paralysis of the legs and wings which was antagonized by choline (80-100 mg/kg). In the rat the effects on neuromuscular transmission were studied by recording the contractions of both gastrocnemius muscles in response to the stimulation of the sciatic nerves. The nerves were regularly stimulated every 5-10 sec for 0.2

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Inhibition of tyrosine hydroxylase by 3-iodo-L-tyrosine

Cited by 25 publications

References 5 publications

In Vitro Inhibition of Noradrenaline‐³H Uptake by Reserpine and Tetrabenazine in Mouse Cerebral Cortex Tissues

In Vitro Inhibition of Noradrenaline‐³H Uptake by Reserpine and Tetrabenazine in Mouse Cerebral Cortex Tissues

Some Pharmacological Actions of Diethyldithiocarbamate on Rabbit and Rat Ileum

Proceedings of the British Pharmacological Society

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Inhibition of tyrosine hydroxylase by 3-iodo-L-tyrosine

Cited by 25 publications

References 5 publications

In Vitro Inhibition of Noradrenaline‐3H Uptake by Reserpine and Tetrabenazine in Mouse Cerebral Cortex Tissues

In Vitro Inhibition of Noradrenaline‐3H Uptake by Reserpine and Tetrabenazine in Mouse Cerebral Cortex Tissues

Some Pharmacological Actions of Diethyldithiocarbamate on Rabbit and Rat Ileum

Proceedings of the British Pharmacological Society

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In Vitro Inhibition of Noradrenaline‐³H Uptake by Reserpine and Tetrabenazine in Mouse Cerebral Cortex Tissues

In Vitro Inhibition of Noradrenaline‐³H Uptake by Reserpine and Tetrabenazine in Mouse Cerebral Cortex Tissues