Inhibition of ultraviolet light-induced erythema by antioxidants

Roshchupkin, D. I.; Pistsov, M. Yu.; Potapenko, A. Ya.

doi:10.1007/bf00412867

Cited by 72 publications

(38 citation statements)

References 6 publications

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“…The inefficacy of melatonin when applied after irradiation in humans, reported by Bangha et al [20], could be confirmed. In contrast to these results, some studies demonstrated a diminished erythemal response when antioxidants, such as α-tocopherol or its acetate ester, were applied after UVR exposure [7, 13, 14, 15]. These studies were done, however, with animals, using different formulations and dosage regimens, or under less life-realistic conditions (e.g.…”

Section: Discussionmentioning

confidence: 86%

“…Whereas the photoprotective effect of topical antioxidants applied before UVR exposure is being recognized [7, 8, 9, 10, 11, 12], the effect of these compounds administered after irradiation is unclear. Reduced erythema formation was reported when antioxidants, such as α-tocopherol or α-tocopherol acetate, were topically administered after UVR exposure [7, 13, 14, 15]. However, several studies demonstrated no diminished UVR-related skin responses when antioxidants were applied topically after irradiation [16, 17].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, apart from using chemical and/or physical sunscreens, supplementation of the skin with antioxidants and thereby strengthening its antioxidant capacity is a further approach in limiting UVR-induced skin damage [5, 6]. Whereas the photoprotective effect of topical antioxidants applied before UVR exposure is being recognized [7, 8, 9, 10, 11, 12], the effect of these compounds administered after irradiation is unclear. Reduced erythema formation was reported when antioxidants, such as α-tocopherol or α-tocopherol acetate, were topically administered after UVR exposure [7, 13, 14, 15].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Topical Antioxidants on UV-Induced Erythema Formation when Administered after Exposure

et al. 1999

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Background: Photoprotective effects of topically applied antioxidants when applied before ultraviolet radiation (UVR) exposure are well known. Their protective effect when applied after UVR exposure is, however, less established. Objective: In a randomized, double-blinded, placebo-controlled human study the short-term photoprotective effects of different antioxidants and of their combinations were evaluated when applied after UVR exposure. Methods: Melatonin (N-acetyl-5-methoxytryptamine), vitamin E (α-tocopherol) and vitamin C (ascorbic acid) were topically administered alone or in combination following UVR exposure as single applications (immediately or 30 min after irradiation, respectively) or as multiple applications (three times: 30 min, 1 h and 2 h after irradiation). The erythemal reaction was evaluated visually and noninvasively with bioengineering methods (skin color and skin blood flow). Results: No significant protective effect of melatonin or the vitamins when applied alone or in combination were obtained when antioxidants were applied after UVR exposure. No improved photoprotective effect was obtained when multiple applications were done. Conclusion: UVR-induced skin damage is a rapid event, and antioxidants possibly prevent such damage only when present in relevant concentration at the site of action beginning and during oxidative stress.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Topical Antioxidants on UV-Induced Erythema Formation when Administered after Exposure

et al. 1999

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“…Considerable interest has been recently raisedconcerning the use of natural compounds in skin protection. Various antioxidants such as vitamin C (5,6), vitamin E (ct-tocopherol, 5,7,8) and their combination (9) …”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Morreale

Livrea

1997

IUBMB Life

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Summary. Considerable interest has been raised concerning the use of natural compounds in preventing skin aging and photoaging In the idea that the combined action of agents increasing epiderlnal turnover with antioxidants could be ach,antageous in cosmetic and therapeuthic treatments, we first investigated if ~z-glycolic acid affected or prevented the antioxidant activity of vitanffn E and of melatonin, two compounds found beneficial as topical photoprotectant. Assays were carried out m vitro either in a biomimetic liposomal system, or in human skin homogenates. Lipid peroxidation was monitored spectrophotometrically by the time course of lipid hydroperoxide production in liposomes and by formation of TBA reactive substances (TBARS) in skin homogenates. Glycolic acid. at 25 ~tM to 1 raM, showed a mild, concentration-dependent antioxidant effect in liposomes, as evalnated by a slight decrease of the peroxidation rate, while, at I mM, reduced TBARS production in skin homogenates by 14 %. Combinations of either vitamin E or melatonin with giycolic acid, in a 1:5 to 1:200 molar ratio, resulted in a clear synergistic protection of liposomes, more evident for the combination of glycolic acid with vitamin E An amount of ~'nergism up to 250% and up to 80% was evahmted with vitamin E and melatonin, respectively. Consumption rate ofvitanffn E during peroxidation of liposomes, in the absence or in the presence of glycolic acid, suggests that regeneration of vitamin E 1nay in part explain the observed synergism. Synergistic antioxidant activity between vitamin E and giycolic acid was also observed in skin homogenates, whereas the effect of glycolic acid on the antioxidunt activity of melatonin appeared additive. However, the combination of these three compounds inhibited TBARS production almost completely.Our data provide evidence that glycolic acid can strongly potentiate the antioxidant action of melatonin and vitamin E. Tiffs may suggest the advantage of combining ~-glycolic acid with these antioxidants in skin designed preparations, both to improve penetration and availability of antioxidants to epidermal layers and to enhance their protective potential.

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“…Roshchupkin and coworkers [130] reported an up to 50% inhibition of UV light induced erythema in hairless mice when they applied tocopherol onto the skin 60 min before or shortly after UV irradiation.…”

Section: Photoprotecuve Properties Of Vitamin E In Animal Modelsmentioning

confidence: 98%

The role of vitamin E in normal and damaged skin

Nachbar

1995

J Mol Med

141

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The generation of free oxygen radicals is believed to play an important pathogenic role in the development of various disorders. More than other tissues, the skin is exposed to numerous environmental chemical and physical agents such as ultraviolet light causing oxidative stress. In the skin this results in several short- and long-term adverse effects such as erythema, edema, skin thickening, wrinkling, and an increased incidence of skin cancer or precursor lesions. However, accelerated cutaneous aging under the influence of ultraviolet light, usually termed photoaging, is only one of the harmful effects of continual oxygen radical production in the skin. Others include cutaneous inflammation, autoimmunological processes, keratinization disturbances, and vasculitis. Vitamin E is the major naturally occurring lipid-soluble non-enzymatic antioxidant protecting skin from the adverse effects of oxidative stress including photoaging. Its chemistry and its physiological function as a major antioxidative and anti-inflammatory agent, in particular with respect to its photoprotective, antiphotoaging properties, are described by summarizing animal studies, in vivo tests on human skin and biochemical in vitro investigations. The possible therapeutic use in different cutaneous disorders, and pharmacological and toxicological aspects are discussed. Many studies document that vitamin E occupies a central position as a highly efficient antioxidant, thereby providing possibilities to decrease the frequency and severity of pathological events in the skin. For this purpose increased efforts in developing appropriate systemic and local pharmacological preparations of vitamin E are required.

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Inhibition of ultraviolet light-induced erythema by antioxidants

Cited by 72 publications

References 6 publications

Effect of Topical Antioxidants on UV-Induced Erythema Formation when Administered after Exposure

Effect of Topical Antioxidants on UV-Induced Erythema Formation when Administered after Exposure

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

The role of vitamin E in normal and damaged skin

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