2004
DOI: 10.1182/blood-2004-05-1851
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Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML

Abstract: IntroductionThe initial, chronic stage of chronic myeloid leukemia (CML) is strictly dependent on signals emanating from the deregulated protein tyrosine kinase Bcr-Abl. 1 Although the Bcr-Abl signaling cascade is incompletely understood, the premise that CML can be treated by selective inhibition of Bcr-Abl kinase activity has been validated in the clinic. [2][3][4] Imatinib mesylate (Gleevec, STI571), a protein tyrosine kinase inhibitor with a narrow specificity profile (Abl, ARG, Kit, and platelet-derived g… Show more

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Cited by 179 publications
(129 citation statements)
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References 41 publications
(44 reference statements)
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“…31 Even the new generation BCR/ABL inhibitor that seems to bind the activated form of the kinase with the much higher affinity, and is aimed at circumventing resistance to imatinib, displays crossreactivity with at least one other tyrosine kinase, src. 32 The major controversy in the field seems to be the question if NPM/ALK activates STAT3 and other signaling proteins directly or via activation of other kinases, in particular, Jak3. 17,26 Recent study 33 that utilized tandem mass spectrometry indicates that NPM/ALK might interact with as many as 46 different proteins that include Jak3.…”
Section: Discussionmentioning
confidence: 99%
“…31 Even the new generation BCR/ABL inhibitor that seems to bind the activated form of the kinase with the much higher affinity, and is aimed at circumventing resistance to imatinib, displays crossreactivity with at least one other tyrosine kinase, src. 32 The major controversy in the field seems to be the question if NPM/ALK activates STAT3 and other signaling proteins directly or via activation of other kinases, in particular, Jak3. 17,26 Recent study 33 that utilized tandem mass spectrometry indicates that NPM/ALK might interact with as many as 46 different proteins that include Jak3.…”
Section: Discussionmentioning
confidence: 99%
“…Novel inhibitors are being generated to overcome IM resistance (Reddy, 2003;O'Hare et al, 2004;Shah et al, 2004), but mutations causing resistance against new drugs are likely to emerge (Burgess et al, 2005;von Bubnoff et al, 2005).…”
Section: Facilitation Of Genomic Instabilitymentioning
confidence: 99%
“…15 The WT and ABL-T315I constructs have been described. 16 Kinase autophosphorylation assays were performed in the presence of imatinib (0-5 mM) as described. 16 Equal protein loading was confirmed by immunoblotting using the Ab-2 antibody (Oncogene Science, Cambridge, MA, USA).…”
Section: Abl Autophosphorylation and Substrate Phosphorylation Assaysmentioning
confidence: 99%