Inhibitive Effect of Resveratrol on the Inflammation in Cultured Astrocytes and Microglia Induced by Aβ1–42

Zhao, Haifeng; Wang, Qian; Cheng, Xuejiao; Xuemin, Li; Li, Na; Liu, Tiantian; Li, Jing; Qin, Yang; Dong, Ruirui; Zhang, Yusen; Zhang, Luping

doi:10.1016/j.neuroscience.2018.03.047

Cited by 63 publications

(34 citation statements)

References 46 publications

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“…Notably, the administration of resveratrol ameliorated mechanical allodynia and decreased the level of in ammatory cytokines in the SDH while inhibiting the microglia activation. Similar inhibitory effects of resveratrol on in ammation were observed in the nerve injury model lacking DAP12 or TREM2, and AD model [24,33,34]. These results suggested that microglia activation was inhibited by resveratrol in the pathology of NeuP.…”

Section: Discussionsupporting

confidence: 68%

Resveratrol Mediates Mechanical Allodynia Through Modulating Inflammatory Response via the TREM2-autophagy Axis in SNI Rat Model

Wang

Shi

Huang

et al. 2020

Preprint

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Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting inflammatory response in NeuP. Recently, the triggering receptor expressed on myeloid cells 2 (TREM2) expressed by microglia was identified as a critical factor of inflammation in nervous system diseases. In this study, we explored whether resveratrol could ameliorate neuroinflammation and produce anti-mechanical allodynia effects via regulating TREM2 in spared nerve injury rats, as well as investigated the underlying mechanisms. Methods A spared nerve injury (SNI) rat model was performed to investigate whether resveratrol could exert anti-mechanism allodynia effects via inhibiting neuroinflammation. To evaluate the role of TREM2 in anti-neuroinflammatory function of resveratrol, Lentivirus coding TREM2 was intrathecal injected into SNI rats to activate TREM2 and the pain behavior was detected by the Von Frey test. Furthermore, 3-Methyladenine (3-MA, an autophagy inhibitor) was performed to analyze the molecular mechanisms of resveratrol-mediated anti-neuroinflammation using Western blot, qPCR, immunofluorescence. Results The TREM2 expression and number of the microglial cell was significantly increased in the ipsilateral spinal dorsal horn after SNI. We found that intrathecal administration of resveratrol (300ug/day) alleviated mechanical allodynia; obviously enhanced autophagy; and markedly reduced the levels of interleukin-1β, interleukin-6, and tumor necrosis factor-α in the ipsilateral spinal dorsal horn after SNI. Moreover, the number of Iba-1+ microglial cells and TREM2 expression were downregulated after resveratrol treatment. Intrathecal administration of lentivirus coding TREM2 and/or 3-methyladenine in those rats induced deficiencies in resveratrol-mediated anti-inflammation, leading to mechanical allodynia that could be rescued via administration of Res. Furthermore, 3-MA treatment contributed to TREM2-mediated mechanical allodynia. Conclusions Taken together, these data reveal that resveratrol relieves neuropathic pain through suppressing microglia-mediated neuroinflammation via regulating the TREM2-autophagy axis in SNI rats.

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Section: Discussionsupporting

confidence: 68%

Resveratrol Mediates Mechanical Allodynia Through Modulating Inflammatory Response via the TREM2-autophagy Axis in SNI Rat Model

Wang

Shi

Huang

et al. 2020

Preprint

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“…Several studies show that the anti-neuroinflammatory effect of RV is related to the inhibition of NF-κB. In rat astrocytes and microglial cell lines, RV reduces the inflammation induced by Aβ1-42 through the inhibition of the NF-κB signal pathway (Zhao et al, 2018). In rodents, a reduction of NK-κB activation was observed after RV treatment both in ovariectomized FIGURE 1 | Neuroprotective mechanisms described for Resveratrol.…”

Section: Neuroprotective Effects Of Resveratrol In Alzheimer's Diseasementioning

confidence: 99%

“…RV can exert protection against neuronal oxidative damage in different ways. It can increase the intracellular antioxidant levels, such as glutathione (Sharma and Gupta, 2002;Savaskan et al, 2003;Kwon et al, 2010) and antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and HO-1 (Chiang et al, 2018;Lin et al, 2018;Zhao et al, 2018;Kong et al, 2019), and decrease lipid peroxidation (Sharma and Gupta, 2002;Kong et al, 2019). Moreover, RV prevents the disruption of mitochondrial membrane potential, reducing ROS production in brain tissue (Kwon et al, 2010).…”

Section: Neuroprotective Effects Of Resveratrol In Alzheimer's Diseasementioning

confidence: 99%

Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease

Arbo

André‐Miral

Nasre-Nasser

et al. 2020

Front. Aging Neurosci.

103

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Neurodegenerative diseases are characterized by the progressive loss of neurons in different regions of the nervous system. Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative diseases, and the symptoms associated with these pathologies are closely related to the regions that are most affected by the process of neurodegeneration. Despite their high prevalence, currently, there is no cure or disease-modifying drugs for the treatment of these conditions. In the last decades, due to the need for the development of new treatments for neurodegenerative diseases, several authors have investigated the neuroprotective actions of naturally occurring molecules, such as resveratrol. Resveratrol is a stilbene found in several plants, including grapes, blueberries, raspberries, and peanuts. Studies have shown that resveratrol presents neuroprotective actions in experimental models of AD and PD, however, its clinical application is limited due to its rapid metabolism and low bioavailability. In this context, studies have proposed that structural changes in the resveratrol molecule, including glycosylation, alkylation, halogenation, hydroxylation, methylation, and prenylation could lead to the development of derivatives with enhanced bioavailability and pharmacological activity. Therefore, this review article aims to discuss how resveratrol derivatives could represent viable molecules in the search for new drugs for the treatment of AD and PD.

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“…A trend towards increased serum SIRT concentration was recorded in a four-week study giving rats 10 mg/kg/day of resveratrol per day (p = 0.011 compared to placebo) [42]. Resveratrol through SIRT-1 may lead to reduced Aβ42-induced neuroinflammation due to inhibition of the NF-κB [43] signal pathway and removal of free radicals [44].…”

Section: Subject Of the Study Dose Effect Referencementioning

confidence: 99%

Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease

Wiciński

Domanowska

Wódkiewicz

et al. 2020

IJMS

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The lack of effective Alzheimer's disease treatment is becoming a challenge for researchers and prompts numerous attempts to search for and develop better therapeutic solutions. Compounds that affect several routes of the neurodegeneration cascade leading to the development of disease are of particular interest. An example of such substances is resveratrol and its synthetic and natural derivatives, which have gained popularity in recent years and show promise as a possible new therapeutic option in the approach to Alzheimer's disease treatment. In this article, the state of the art evidence on the role of resveratrol (RSV) in neuroprotection is presented; research results are summarized and the importance of resveratrol and its derivatives in the treatment of Alzheimer's disease are underlined. It also focuses on various modifications of the resveratrol molecule that should be taken into account in the design of future research on drugs against Alzheimer's disease.

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Inhibitive Effect of Resveratrol on the Inflammation in Cultured Astrocytes and Microglia Induced by Aβ1–42

Cited by 63 publications

References 46 publications

Resveratrol Mediates Mechanical Allodynia Through Modulating Inflammatory Response via the TREM2-autophagy Axis in SNI Rat Model

Resveratrol Mediates Mechanical Allodynia Through Modulating Inflammatory Response via the TREM2-autophagy Axis in SNI Rat Model

Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease

Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease

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