Inhibitive effects of quinestrol on male testes in Mongolian gerbils (Meriones unguiculatus)

Shen, Wei; Shi, Dazhao; Deng, Wang; Guo, Yongwang

doi:10.1016/j.rvsc.2011.10.010

Cited by 14 publications

(15 citation statements)

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“…However, reported that EP-1 (levonorgestrel and quinestrol) significantly reduces both size and mass of testis, epididymis and spermotophore in male greater longtailed hamsters. In the present study, the total amount of quinestrol ingested by male rats was 5.73 ± 1.09 mg·kg -1 (BM) in the treatment group, which was a higher total dose than that ingested by male T. triton (2.8 mg·kg -1 ; Zhang et al 2006) and male L. brandtii (1.65 and 4.62 mg·kg -1 ; Zhao et al 2007), but less than that by male L. brandtii (5-40 mg·kg -1 ; Wang et al 2011) and male M. unguiculatus (35 mg·kg -1 ;Shen et al 2011). The difference in testis size reduction between our study and the above 2 studies could be attributed to treatment time and estrogen sensitivity.…”

Section: Effects Of Quinestrol On Reproductive Organsmentioning

confidence: 91%

“…The difference in testis size reduction between our study and the above 2 studies could be attributed to treatment time and estrogen sensitivity. Most of these studies measured the size and/or mass of testis from day 14 onward after commencement of treatment Zhao et al 2007;Shen et al 2011;Wang et al 2011); in contrast, we measured on day 10, when the time since treatment might not have been sufficient to see a reduced mass of testis in male R. nitidus. In the present study, the total amount of quinestrol ingested by male rats was 5.73 ± 1.09 mg·kg -1 (BM) in the treatment group, which was a higher total dose than that ingested by male T. triton (2.8 mg·kg -1 ; Zhang et al 2006) and male L. brandtii (1.65 and 4.62 mg·kg -1 ; Zhao et al 2007), but less than that by male L. brandtii (5-40 mg·kg -1 ; Wang et al 2011) and male M. unguiculatus (35 mg·kg -1 ;Shen et al 2011).…”

Section: Effects Of Quinestrol On Reproductive Organsmentioning

confidence: 99%

“…Each method has a unique set of advantages and disadvantages that influence the practicality of use in managing wildlife damage. Quinestrol has an infertility effect on both male and female rodents (Zhang et al 2005Huo et al 2006;Liang et al 2006;Zhao et al 2007;Shen et al 2011;Wang et al 2011); with its long-lasting effects, quinestrol has high potential as a rodent contraceptive. Additional laboratory and field experiments also showed that EP-1 and its components, levonorgestrel and quinestrol, affected the structure of the reproductive organs, and exerted anti-fertility effects in wild rodents, such as the greater long-tailed hamster [Tscherskia triton (de Winton, 1899)] (Zhang et al 2005, the Djungarian hamster [Phodopus campbelli (Thomas, 1905)] (Wan et al 2006), Mongolian gerbils [Meriones unguiculatus (Milne-Edwars, 1867)] Liang et al 2006) and Brandt's voles (Zhao et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Additional laboratory and field experiments also showed that EP-1 and its components, levonorgestrel and quinestrol, affected the structure of the reproductive organs, and exerted anti-fertility effects in wild rodents, such as the greater long-tailed hamster [Tscherskia triton (de Winton, 1899)] (Zhang et al 2005, the Djungarian hamster [Phodopus campbelli (Thomas, 1905)] (Wan et al 2006), Mongolian gerbils [Meriones unguiculatus (Milne-Edwars, 1867)] Liang et al 2006) and Brandt's voles (Zhao et al 2007). Quinestrol has an infertility effect on both male and female rodents (Zhang et al 2005Huo et al 2006;Liang et al 2006;Zhao et al 2007;Shen et al 2011;Wang et al 2011); with its long-lasting effects, quinestrol has high potential as a rodent contraceptive.…”

Section: Introductionmentioning

confidence: 99%

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Fertility control of Rattus nitidus using quinestrol: effects on reproductive organs and social behavior

Liu¹,

Qin

Chen³

et al. 2012

Integrative Zoology

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Fertility control has been identified by studies in the laboratory and the field as a more appropriate and long-term control strategy for rodent pests than lethal control. In this study, we investigated the effects of quinestrol on mass of reproductive organs and on social behaviors in female and male Indochinese forest rat (Rattus andamanensis (Blyth, 1860)] using approach of morphometrics and genetics). [corrected]. A total of 16 adult females and 16 adult males were randomly assigned to 4 groups. One male and one female group were fed rice with 0.005% quinestrol by weight for 7 days, and another 2 groups were fed rice only. After 7 days, rats were assigned to 10 min dyadic encounters between groups, and investigation, aggression, defense and attack latency were quantified. All animals were killed on day 10, and reproductive organs were dissected and weighed. Dyadic encounter data showed that there were obvious changes in social behaviors of quinestrol-treated rats. Quinestrol significantly inhibited the investigative behavior of quinestrol-treated males toward control females in Rattus nitidus, but seldom affected investigation between control males and quinestrol-treated females. Aggression of control females toward quinestrol-treated males was higher than that of quinestrol-treated females, and defense of quinestrol-treated males toward control females was more remarkable than that of control males. Quinestrol remarkably decreased wet masses of epididymis and spermotophore in males and ovaries in females, but had no effect on wet masses of testes and uteri after quinestrol treatment. These results indicate that the anti-fertility effects of quinestrol on R. nitidus are attributed to not only suppressing reproductive organs but also impacting social behaviors associated with territory defense and mate choice.

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Section: Effects Of Quinestrol On Reproductive Organsmentioning

confidence: 91%

Section: Effects Of Quinestrol On Reproductive Organsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fertility control of Rattus nitidus using quinestrol: effects on reproductive organs and social behavior

Liu¹,

Qin

Chen³

et al. 2012

Integrative Zoology

Self Cite

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show abstract

“…Many ways and mechanisms are involved inside the body to protect cells against damage caused by oxidative free radicals, including SOD and GSH-Px. MDA is the main product of lipid peroxidation which plays a big role in cytotoxicity [29], and the content of MDA also increased in high fat diet mice [30]. After being treated with BPA, the serum levels of SOD and GSH-Px were significantly decreased ( P < 0.01), while the MDA level was increased significantly ( P < 0.01) versus the control group (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects ofLycium barbarumPolysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice

Zhang

An-zhong

Sun

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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To observe the effects of Lycium barbarum polysaccharides (LBP) on testis spermatogenic injuries induced by Bisphenol A (BPA) in mice. BPA was subcutaneously injected into mice at a dose of 20 mg/kg body weight (BW) for 7 consecutive days. LBP was administered simultaneously with BPA by gavage daily at the dose of 50, 100, and 200 mg/kg BW for 7 days. After treatment, the weight and the histopathology changes of testis and epididymis were examined; the contents of T, LH, GnRH, antioxidant enzyme, and malondialdehyde (MDA) in serum were detected; proapoptotic protein Bax and antiapoptotic protein Bcl-2 were also detected by immunohistochemical method. Results showed that the weights of testis and epididymis were all increased after supplement with different dosages of LBP compared with BPA group, and the activities of SOD and GSH-Px were significantly increased in LBP groups, while MDA contents were gradually decreased. Moreover, the levels of T, LH, and GnRH were significantly elevated in serum treated with 100 mg/kg LBP. LBP also shows significant positive effects on the expression of Bcl-2/Bax in BPA treated mice. It is concluded that LBP may be one of the potential ingredients protecting the adult male animals from BPA induced reproductive damage.

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The Mongolian Gerbil as a Useful Experimental Model in Reproductive Biology

et al. 2023

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Inhibitive effects of quinestrol on male testes in Mongolian gerbils (Meriones unguiculatus)

Cited by 14 publications

References 41 publications

Fertility control of Rattus nitidus using quinestrol: effects on reproductive organs and social behavior

Fertility control of Rattus nitidus using quinestrol: effects on reproductive organs and social behavior

Protective Effects ofLycium barbarumPolysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice

The Mongolian Gerbil as a Useful Experimental Model in Reproductive Biology

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