Inhibitors of apoptosis: clinical implications in cancer

Mohamed, Mervat S.; Bishr, Mai K.; Almutairi, Fahad M.; Ali, Ayat G.

doi:10.1007/s10495-017-1429-4

Cited by 134 publications

(118 citation statements)

References 275 publications

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“…Apoptosis is an essential process for the homeostasis of multicellular organisms. Strict regulation of apoptosis plays a vital role in cancer . There are two main pathways of apoptotic cell death: one involves interactions of cell surface receptors, such as Fas and tumor necrosis factor‐α1, with their ligands, whereas the second pathway involves the mitochondria .…”

Section: Discussionmentioning

confidence: 99%

“…Strict regulation of apoptosis plays a vital role in cancer. 12 There are two main pathways of apoptotic cell death: one involves interactions of cell surface receptors, such as Fas and tumor necrosis factor-α1, with their ligands, whereas the second pathway involves the mitochondria. 13 We used flow cytometry to detect apoptosis in GC cell lines with knocked down LRRN1, and the results showed that knocking down LRRN1 enhanced the apoptosis of GC cells.…”

Section: Discussionmentioning

confidence: 99%

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Leucine‐rich repeat neuronal protein‐1 suppresses apoptosis of gastric cancer cells through regulation of Fas/FasL

et al. 2019

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Gastric cancer (GC) is a common cause of cancer‐related death worldwide. As a result of the lack of reliable diagnostic or prognostic biomarkers for GC, patient prognosis is still poor. Therefore, there is an urgent need for studies examining the underlying pathogenesis of GC in order to find effective biomarkers. LRRN1 (leucine‐rich repeat neuronal protein‐1) is a type I transmembrane protein that plays an important role in the process of nerve development and regeneration. However, its role in cancer, especially in GC, remains unclear. In the present study, we found that LRRN1 expression is upregulated in GC tissues and that high LRRN1 expression is associated with poor prognosis. siRNA and shRNA‐mediated knockdowns of LRRN1 expression promoted GC cell apoptosis and activation of the Fas/FasL pathway. LRRN1 knockdown also resulted in upregulation of JUN, a subunit of the transcription factor AP‐1 (activator protein‐1). This suggests that LRRN1 suppresses GC cell apoptosis by downregulating AP‐1, resulting in inhibition of the Fas/FasL pathway. These results confirm that LRRN1 plays a significant role in GC pathogenesis. Moreover, LRRN1 may be a potential prognostic biomarker and therapeutic target for GC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Leucine‐rich repeat neuronal protein‐1 suppresses apoptosis of gastric cancer cells through regulation of Fas/FasL

et al. 2019

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“…New research confirms that receptor for advanced glycation endproduct (RAGE) can specifically deliver DADS into three negative breast cancer cells and significantly enhance the cytotoxicity of DADS by reducing anti-apoptotic proteins and upregulation of pro-apoptotic protein [72]. The researchers have found that DADS-RAGE-SLN can be obviously absorbed by MDA-MB231 and upregulate the expression of pro-apoptotic proteins (Bax, caspase-3, and caspase-9) and downregulate the expression of antiapoptotic proteins, such as Bcl-2 family (Bcl-2, Bcl-xl, Mcl-1) and survivin through the experiment of establishing the model of solid lipid nanoparticles with DADS-loaded solid lipid location nanoparticles (DADS-SLN), and DADS-loaded solid lipid location nanoparticles with the RAGE positioning (DADS-RAGE-SLN) [72]. In fact, caspase-3 plays an important role as the central effector for initiation of apoptosis [73].…”

Section: Activation Of the Apoptotic Pathways By Dadsmentioning

confidence: 90%

The Progress of Diallyl Disulfide in Anti-Cancer

Lz¹,

Liao²,

Wang³

et al. 2017

Chemotherapy

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Considerable evidence in recent years suggests that garlic has anti-proliferative effects on various types of cancer. Garlic contains water-soluble and oil-soluble sulfur compounds. Oil-soluble compounds (OSCs), such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS) and ajoene are more effective than watersoluble compounds in protection against cancer. DADS, a major organosulfur compound derived from garlic, can reduce carcinogen-induced cancers in experimental animals and inhibit the proliferation of various types of cancer cells. The mechanisms of these action of DADS include activation of metabolic enzymes that detoxify carcinogens, suppression of the formation of DNA adducts, antioxidant effects, regulation of cell-cycle progression, induction of apoptosis, and inhibition of angiogenesis and metastasis. These topics are discussed in depth in this review.

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“…Survivin has the potential to suppress both extrinsic and intrinsic apoptotic pathways. XIAP is the most powerful suppressor for caspases (Mohamed, Bishr, Almutairi, & Ali, ). The rate of expressions for various apoptotic and anti‐apoptotic factors involved in both apoptotic pathways is changed in HCC (Breinig, Schirmacher, & Kern, ) (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Human hepatocellular carcinoma: Protection by melatonin

Mortezaee

2018

Journal Cellular Physiology

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Despite great scientific breakthroughs toward understanding the identity of human hepatocellular carcinoma (HCC) mechanistically, there are still no clinically efficient therapeutic methods for this cancer. Melatonin (N-acetyl-5-methoxytryptamine) is a multi-tasking hormone that has long been known for its anti-cancer activity against various human cancers including HCC, which is a focus of this review. PubMed database was searched for relevant articles with the keywords: hepatocellular carcinoma (HCC), melatonin, apoptosis, proliferation, invasion, angiogenesis, autophagy, oxidative stress, tumor immunity, and mitogen-activated protein kinase (MAPK) focusing on just human cell lines and English language articles. Melatonin inhibits apoptosis resistance and activates both extrinsic and intrinsic pathways of apoptosis in HCC. Melatonin induces ensoplasmic reticulum (ER)- and autophagy-mediated apoptosis in cancer cells. Melatonin works against cancer cell proliferation, motility, and invasiveness by modulating actions of a variety of transcription factors and related pathways. Melatonin also relieves an immunosuppressive state in HCC cancer cells through making a control over tumor-derived exosomes. Both pro-and anti-oxidative functions of melatonin are necessary for combating HCC. Combination of melatonin with chemotherapy could also provide cumulative effects on cancer cells. Melatonin exerts most of these roles by acting on the members of MAPK family.

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Inhibitors of apoptosis: clinical implications in cancer

Cited by 134 publications

References 275 publications

Leucine‐rich repeat neuronal protein‐1 suppresses apoptosis of gastric cancer cells through regulation of Fas/FasL

Leucine‐rich repeat neuronal protein‐1 suppresses apoptosis of gastric cancer cells through regulation of Fas/FasL

The Progress of Diallyl Disulfide in Anti-Cancer

Human hepatocellular carcinoma: Protection by melatonin

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