2011
DOI: 10.1248/bpb.34.462
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Inhibitors of Autoactivation of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease)

Abstract: Plasma hyaluronan-binding protein (PHBP), a serine protease that can activate coagulation factor VII and prourokinase, circulates in a single-chain form (pro-PHBP) and autoproteolytically converts to an active twochain form with the aid of an effector such as spermidine and heparin. It has been postulated that PHBP plays roles in regulating inflammation, vascular function, fibrosis and atherosclerosis. From the comprehensive screening of natural sources for inhibitors of spermidine-induced pro-PHBP autoactivat… Show more

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Cited by 10 publications
(13 citation statements)
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“…10,[14][15][16] Most of these inhibitors have a polyphenol feature. In particular, potent inhibitors have plural catechol units, such as galloyl and caffeoyl groups.…”
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confidence: 99%
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“…10,[14][15][16] Most of these inhibitors have a polyphenol feature. In particular, potent inhibitors have plural catechol units, such as galloyl and caffeoyl groups.…”
mentioning
confidence: 99%
“…In particular, potent inhibitors have plural catechol units, such as galloyl and caffeoyl groups. 15) Since catechol attenuates the inhibitory action of these inhibitors, the presence of catechol-binding sites in pro-PHBP has been postulated. 15) In this study, we investigated the structureactivity relationships of catechol-based compounds to facilitate the designing of a potent inhibitor.…”
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confidence: 99%
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