Inhibitors of the plasminogen-activation in patients with primary “Carbohydrate-induced” hypertriglyceridemia

Spöttl, F; Holzknecht, F; Braunsteiner, H

doi:10.1016/s0368-1319(68)80044-4

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…These findings are consistent with the previous studies in Chinese adults [25, 26] and other ethnic populations [27–29]. TG increase may promote hypertension by the development of atherosclerotic changes in blood vessels [30]. Moreover, the pre-3-lipoprotein fraction rich in endogenous triglycerides inhibits the plasminogen activator secretion in the blood vessel wall and its deficiency may cause inhibition of fibrinolysis.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, the pre-3-lipoprotein fraction rich in endogenous triglycerides inhibits the plasminogen activator secretion in the blood vessel wall and its deficiency may cause inhibition of fibrinolysis. The fibrinolysis inhibition also can promote hypertension by the development of atherosclerotic changes in blood vessels [30]. Hyperglycemia can alter intracellular signaling pathway leading to endothelial dysfunction, which was associated with increased blood pressure [31, 32].…”

Section: Discussionmentioning

confidence: 99%

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The Association of Hypertension with Obesity and Metabolic Abnormalities among Chinese Children

Zhang

et al. 2011

International Journal of Hypertension

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A total of 8898 Chinese children (4580 boys and 4318 girls) aged 7–13 years in 6 cities of east China were recruited. Data on height, weight, waist circumference, blood pressure, serum lipid profiles, glucose, and insulin were collected. The overall prevalence of hypertension was 11.1%. Overweight and obese children had a higher risk of developing hypertension than their counterparts (29.1%, 17.4%, and 7.8%, resp.) (P = 0.0001). The means levels of triglycerides, glucose, insulin, and HOMA-IR (1.0 mmol/L, 4.5 mmol/L, 8.4 mU/mL and 1.7, resp.) among hypertensive children were all significantly higher than their normotensive counterparts (0.8 mmol/L, 4.5 mmol/L, 5.9 mU/mL, and 1.2, resp.) (P = 0.0001). Compared with the healthy children, the risk (odds ratio, OR) of having hypertension among children with high triglycerides, hyperglycemia, and metabolic syndrome was 1.4 (95% confidence interval (CI): 1.0–2.0, P = 0.0334), 1.5 (95% CI: 0.9–2.5, P = 0.0890), and 2.8 (95%CI: 1.5–5.4, P = 0.0014), respectively, after controlling for age, gender, BMI, income level, parents' education level and puberty. In conclusion, overweight and obese children have higher risk of having hypertension and children with dyslipidemia, hyperglycemia, and metabolic syndrome and higher HOMA-IR have higher risk of developing hypertension.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The Association of Hypertension with Obesity and Metabolic Abnormalities among Chinese Children

Zhang

et al. 2011

International Journal of Hypertension

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“…It is known that the pre-3-lipoprotein fraction rich in endogenous triglycerides inhibits the plasminogen activator secretion in the blood vessel wall and its deficiency may cause inhibition of fibrinolysis (Spottl et al, 1968). Both triglyceride increase and fibrinolysis inhibition may promote the development of atherosclerotic changes in blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Metabolic and hormonal studies in patients with essential hypertension.

Januszewicz¹,

Ciświcka-Sznajderman²,

Wocial³

et al. 1977

Heart

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In 106 patients with essential hyp3rtension and different plasma renin activity several hormonal and metabolic factors were studied: urinary excretion of catecholamines, blood levels of cholesterol and triglycerides, levels of glycaemia and insulinaemia after glucose load and plasma fibrinolytic activity. The plasma renin activity in 46-2 per cent ofpatients was normal, whereas in 25-5 per cent it was low, and in 28-3 per cent it was high. In patients with high plasma renin activity the excretion of noradrenaline and adrenaline was relatively high while that of dopamine was low. Significantly lower triglyceride levels were found in patients with low plasma renin activity in comparison with those with high and normal plasma renin activity. There was also a statistically significant difference in the euglobulin lysis time which was shortest in patients with low and longest in patients with normal plasma renin activity. The results of the study show that patients with different plasma renin activity may also differ in some hormonal and metabolic values.It has been shown recently that patients with Patients and methods essential hypertension do not represent a homogeneous population in relation to humoral factors The investigations were carried out in 106 patients (Brunner et al., 1972;DeQuattro and Miura, 1973; with essential hypertension, 41 women and 65 men, Laragh, 1973;Januszewicz and Wocial, 1975). aged 19 to 59 years. The diagnosis of essential Particular attention has been paid to the observa-hypertension was based on the clinical picture and tion that patients with essential hypertension differ special laboratory tests and radiological methods to in relation to plasma renin activity. It was found: exclude secondary forms of hypertension. All that the activity of this enzyme was normal in about patients were in hospital and remained on a standard 50 to 60 per cent of patients, while in others it was diet. They did not receive any hypotensive drugs low or high (Brunner et al., 1972; Crane et al., and other drugs which might have influenced the 1972). Brunner et al. (1972Brunner et al. ( , 1973 suggested that values for at least 3 weeks before the study. patients with different plasma renin activity Plasma renin activity was measured by radiodiffered also in relation to the clinical course of immunoassay of angiotensin I using CEA-IREhypertension and the incidence of cardiovascular SORIN kits. The patients were divided into 3 complications. Though this interesting observation groups on the basis of plasma renin activity; the was not confirmed by other authors (Doyle et al., arithmetic mean of plasma renin activity obtained 1973;Mroczek et al., 1973) it gave an impetus for in the control group of 20 healthy people ± 1 SD was further research to elucidate the relation between accepted as a criterion of division; 49 patients humoral factors and the clinical course of essential (46%) were defined as having normal plasma renin hypertension.activity, 27 patients (26 %) had low, and 30 patients The aim of the present...

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“…[24,28,31]. In previous papers concerning the fibrinolytic system in patients with PCH we have reported on an increase of fibrinogen, proactivator-plasminogen, slow-reacting antiplasmin and in the in hibitors of plasminogen activation by urokinase, whereas PA activity was found to be decreased [28,29,30], The inhibition of PA release from the vessel wall is supposed by H ow ell [18] to be one of the points, where the plasminogen activation sequence is blocked by lipids. The purpose of the present study was to investigate the PA release following venous occlusion in patients with PCH.…”

Section: Enhancement Of the Fibrinolytic Activity By Venous Occlusionmentioning

confidence: 90%

“…The PA released by venous occlusion was found to be inversely correlated with the triglyceride and phospholipid level, indicating that these lipids inter fere with the stasis induced activator or its release from the vessel wall. This finding was surprising, since we had evidence that triglycerides or chylomicrons do not inhibit the direct plasminogen activation by urokinase, whether in PCH [30], nor in alimentary hypertriglyceri demia [5,26], nor after infusion of a triglyceride emulsion [10], nor after in vitro addition1. These findings can be explained by means of 2 theories:…”

Section: Prc-occlusion Activator Level : Normal Persons (N-24)mentioning

confidence: 95%

Enhancement of the Fibrinolytic Activity by Venous Occlusion in Patients with Primary ‘Carbohydrate-Induced’ Hypertriglyceridemia

Spöttl¹,

Holzknecht²,

Braunsteiner³

1969

Acta Haematol

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Inhibitors of the plasminogen-activation in patients with primary “Carbohydrate-induced” hypertriglyceridemia

Cited by 9 publications

References 23 publications

The Association of Hypertension with Obesity and Metabolic Abnormalities among Chinese Children

The Association of Hypertension with Obesity and Metabolic Abnormalities among Chinese Children

Metabolic and hormonal studies in patients with essential hypertension.

Enhancement of the Fibrinolytic Activity by Venous Occlusion in Patients with Primary ‘Carbohydrate-Induced’ Hypertriglyceridemia

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