Inhibitory Action of Human Epidermis on Melanin Formation

Rothman, Stephen; Krysa, H; Smiljanic, Adelaide M.

doi:10.3181/00379727-62-15422

Cited by 89 publications

(14 citation statements)

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“…Early studies on pigmentation have documented important relationships between thiols and skin color. Sulfhydryl‐containing compounds in water extracts of human epidermis were observed to prevent the formation of melanin from tyrosine by tyrosinase [7, 8]. Rothman et al.…”

Section: Early Concepts About Effects Of Thiols On Pigmentationmentioning

confidence: 99%

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Glutathione as a depigmenting agent: an overview

Villarama

Maibach

2005

Intern J of Cosmetic Sci

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Glutathione is an ubiquitous compound found in our bodies. Aside from its many ascribed biologic functions, it has also been implicated in skin lightening. We review in vitro and in vivo studies that show evidence of its involvement in the melanogenic pathway and shed light on the its anti-melanogenic effect. Proposed mechanisms of action include: (a) direct inactivation of the enzyme tyrosinase by binding with the copper-containing active site of the enzyme; (b) mediating the switch mechanism from eumelanin to phaeomelanin production; (c) quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin formation; and d) modulation of depigmenting abilities of melanocytotoxic agents. These concepts supported by the various experimental evidence presented form basis for future research in the use of glutathione in the treatment of pigmentary disorders.

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Section: Early Concepts About Effects Of Thiols On Pigmentationmentioning

confidence: 99%

“…Rothman et al. [7] postulated that oxidation of this sulfhydryl compound by X‐ray, UV, heat, inflammation inactivated it and removed its inhibitory effect on tyrosinase leading to hyperpigmentation. Halprin et al.…”

Section: Early Concepts About Effects Of Thiols On Pigmentationmentioning

confidence: 99%

Glutathione as a depigmenting agent: an overview

Villarama

Maibach

2005

Intern J of Cosmetic Sci

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“…It is possible that the supposed inhibitory effect of sulfhydryl groups on the tyrosinetyrosinase system (Rothman, Krysa, and Smiljanic, 1946;Flesch, 1949) varies from region to region. The keratinization of the nasal and oral epithelia differs in some re¬ spects from that of the skin.…”

Section: Commentmentioning

confidence: 99%

Tyrosinase in the Epidermal Melanocytes of White Human Skin

Szabó¹

1957

AMA Arch Derm

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“…The chief obstacle to the study of hereditary variation in the tyrosinase system has been the difficulty to demonstrate the enzyme in vertebrates. ROTHMAN et al (1946) first demonstrated the presence of an inhibitor of tyrosinase in the human skin and the removal of this inhibitor by iodoacetamide. Their findings encouraged us to investigate the mechanism of the formation of the melanin in color varieties of the medaka.…”

Section: Introductionmentioning

confidence: 99%