Inhibitory actions of  Pseuderanthemum palatiferum  (Nees) Radlk. leaf ethanolic extract and its phytochemicals against carbohydrate-digesting enzymes

Pulbutr, Pawitra; Nualkaew, Somsak; Rattanakiat, Sakulrat; Cushnie, Benjamart; Jaruchotikamol, Achida

doi:10.1016/j.apjtb.2015.10.010

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Of interest were the plants found containing compounds with previous literature on the compound’s potential anti-diabetic activity, but to date, the medicinal plant itself has not been evaluated for its potential antidiabetic activity. These plants were Argemone ochroleuca with compounds berberine [49], protopine [50] and sanguinarine [51]; Dioscorea dregeana with compounds dioscin [52,53], diosgenin [18,54] and hiricinol [55]; Dodonaea angustifolia with compounds beta-sitosterol [56] and stigmasterol [57,58]; Melianthus comosus with compounds 3-epioleanolic acid [59] and oleanolic acid [60]; Pelargonium sidoides with compounds catechin [61], gallocatechin [62,63], quercetin [64] and sitosterol-3-glucoside [65,66]; and Vinca minor with compounds eburnamonine and vincamine [67]. These plants represent a good initial point for exploratory in vitro anti-diabetic studies.…”

Section: Resultsmentioning

confidence: 99%

“…The compounds found in the largest cluster of these groups had predominately triterpenoid or steroidal backbones with/without a glycosidic group attached, such as shown in the two centroid compounds maslinic acid and balanitin-6. The compounds corosolic acid, betulinic acid, glycyrrhizin, and sitosterol-3-glucoside with this type of backbone found in the AMY2A group, have been shown in previous literature to inhibit the enzyme [52,66,74].…”

Section: Resultsmentioning

confidence: 99%

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Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server

et al. 2019

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Medicinal plants containing complex mixtures of several compounds with various potential beneficial biological effects are attractive treatment interventions for a complex multi-faceted disease like diabetes. In this study, compounds identified from African medicinal plants were evaluated for their potential anti-diabetic activity. A total of 867 compounds identified from over 300 medicinal plants were screened in silico with the DIA-DB web server (http://bio-hpc.eu/software/dia-db/) against 17 known anti-diabetic drug targets. Four hundred and thirty compounds were identified as potential inhibitors, with 184 plants being identified as the sources of these compounds. The plants Argemone ochroleuca, Clivia miniata, Crinum bulbispermum, Danais fragans, Dioscorea dregeana, Dodonaea angustifolia, Eucomis autumnalis, Gnidia kraussiana, Melianthus comosus, Mondia whitei, Pelargonium sidoides, Typha capensis, Vinca minor, Voacanga africana, and Xysmalobium undulatum were identified as new sources rich in compounds with a potential anti-diabetic activity. The major targets identified for the natural compounds were aldose reductase, hydroxysteroid 11-beta dehydrogenase 1, dipeptidyl peptidase 4, and peroxisome proliferator-activated receptor delta. More than 30% of the compounds had five or more potential targets. A hierarchical clustering analysis coupled with a maximum common substructure analysis revealed the importance of the flavonoid backbone for predicting potential activity against aldose reductase and hydroxysteroid 11-beta dehydrogenase 1. Filtering with physiochemical and the absorption, distribution, metabolism, excretion and toxicity (ADMET) descriptors identified 28 compounds with favorable ADMET properties. The six compounds—crotofoline A, erythraline, henningsiine, nauclefidine, vinburnine, and voaphylline—were identified as novel potential multi-targeted anti-diabetic compounds, with favorable ADMET properties for further drug development.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server

et al. 2019

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“…Prior research revealed ethanolic extracts of the leaves may exert powerful inhibitory action against -amylase and -glucosidase. 19 The inhibitory properties were shown to be much higher than those of stigmasterol and sitogluside isolated from the extracts. Furthermore, in an oral starch tolerance test, the extracts were demonstrated to reduced remarkably blood glucose levels.…”

Section: Inhibition Of -Glucosidasementioning

confidence: 95%

“…Previously, 80% ethanol extract of P. palatiferum leaves was put under a screen test for steroids and the detection of this chemical class was confirmed. 16 In a prior study, leaves of P. palatiferum were shown to contain a considerable amount of -sitosterol, stigmasterol and their glycoside derivatives, [17][18][19] which are phytosterols commonly found in fruits, vegetables, nuts and seeds. Other than that, scarce information about phytochemicals in leaves of P. palatiferum is available in the literature.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Influence of Green Solvent Extraction on Phytochemicals, Potential Antidiabetic and In Vitro Anti-Inflammatory Activities of Pseuderanthemum palatiferum (Nees.) Radlk. Leaves

2023

TJNPR

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Pseuderanthemum palatiferum (Nees.) Radlk., belonging to the Acanthaceae family, is commonly cultivated in Vietnam and Thailand for food and medicinal uses. The aim of the study was to compare phenolic composition, antioxidant, potential anti-inflammatory and antidiabetic activities of different extracts obtained from ethanol, 80% ethanol and water. The use of these solvents significantly affected the extractability of phytochemical classes, phenolic contents and bioactivities in the extracts. The extract obtained from 80% ethanol contained the highest amount of phenolics (113.74  26.17 mg GAE/g). It also appeared to be more suitable for recovering phenolic constituents in P. palatiferum leaves. The extracts obtained from ethanol and 80% ethanol showed significantly higher antioxidant potential and inhibition of -glucosidase compared to water. Regarding inhibition of bovine albumin denaturation, no differences were observed for the extracts at the examined concentration. The research helps better understand phytochemical contents and potential health benefits of P. palatiferum, which could be used for development of new plant-derived agents for disease prevention and treatment.

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Antihyperglycemic and hypoglycemic activity of naturally occurring peptides and protein hydrolysates from easy-to-cook and hard-to-cook beans (Phaseolus vulgaris L.)

Valencia-Mejía

Batista

Acevedo-Fernández

et al. 2019

Food Research International

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Inhibitory actions of Pseuderanthemum palatiferum (Nees) Radlk. leaf ethanolic extract and its phytochemicals against carbohydrate-digesting enzymes

Cited by 5 publications

References 13 publications

Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server

Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server

Influence of Green Solvent Extraction on Phytochemicals, Potential Antidiabetic and In Vitro Anti-Inflammatory Activities of Pseuderanthemum palatiferum (Nees.) Radlk. Leaves

Antihyperglycemic and hypoglycemic activity of naturally occurring peptides and protein hydrolysates from easy-to-cook and hard-to-cook beans (Phaseolus vulgaris L.)

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