Inhibitory Activities of Rhodanine Derivatives on Plant Growth

Recent Pharmacological Developments on Rhodanines and 2,4-Thiazolidinediones

“…Rhodanine-3-acetic acid (RAA) 1 was prepared by Korner [ 2 ] in 1908, and Knoevenagel condensation products of the acid with various aldehydes, namely, [(5 Z )-(5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)]acetic acids 2 were reported in the same year [ 3 ]. From 1960 onwards, studies revealed that such type of molecule exhibit potential antimycobacterial [ 4 , 5 ], antifungal [ 6 – 15 ], pesticidal [ 16 – 18 ], antihypertensive [ 19 ], and antineoplastic [ 20 , 21 ] activities. Their NMR characterization performed in 1982 [ 22 ].…”

Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine‐3‐carboxylic Acids Derivatives

“…2‐Thioxo‐4‐thiazolidinone, commonly known as “rhodanine,” as well as its derivatives possesses a broad spectrum of biological activity. Their antidiabetic, antifungal, antimicrobial, pesticidal, antiapoptotic, and anticancer activities are widely reported . The rhodanine moiety, possessing a variously substituted benzylidene group at C‐5, shows a moderate anticancer activity .…”

Recent Advances in the Biological Importance of Rhodanine Derivatives

“…Because the latter is conjugated to the carbonyl group at position 4 of the rhodanine ring, such compounds are electrophilic and potentially reactive due to possible Michael addition of the nucleophilic protein residues to the exocyclic double bond [3][4][5]. Rhodanine have been found to possess various biological activities, such as antidiabetic, antibacterial, antifungal, anti-infective, pesticidal, antimycobacterial, antineoplastic, and so on [6][7][8][9][10][11][12][13][14][15][16][17][18][19]. They also exhibit antitubercular, anti-human immunodeficiency virus (HIV), and antimalarial activities.…”