Inhibitory Activities of Sesame Seed Extract and its Constituents against β-Secretase

Matsumura, Shinichi; Murata, Kazuya; Zaima, Nobuhiro; Yoshioka, Yuri; Morimoto, Masanori; Matsuda, Hideaki; Iwaki, Masahiro

doi:10.1177/1934578x1601101112

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…In a previous study, we reported that sesamin and sesamolin inhibited β‐secretase activity and were transported to the serum and brain in mice after oral administration (Matsumura et al, , c). However, the absorption rates of sesamin and sesamolin in mice are poor.…”

Section: Discussionmentioning

confidence: 96%

“…Sesame seeds and sesame oil have long been used as healthy foods in Asian countries including Japan, Korea, China, and India. We previously reported that sesamin and sesamolin inhibited β‐secretase activity (Matsumura et al, , c; Murata et al, ). Furthermore, we showed that sesamin and sesamolin were transported to the serum and brain in mice after oral administration (Matsumura et al, , c).…”

Section: Introductionmentioning

confidence: 94%

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Using Turmeric Oil as a Solvent Improves the Distribution of Sesamin‐Sesamolin in the Serum and Brain of Mice

Iwamoto

Matsumura²,

Yoshioka³

et al. 2019

Lipids

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Accumulation of amyloid-β peptide is associated with Alzheimer's dementia. Previously, we reported that sesamin and sesamolin inhibited β-secretase activity in vitro, and each was transported to the serum and brain in mice after oral administration. However, the bioavailability of sesamin and sesamolin was poor in mice. In this study, we aimed to improve the bioavailability of sesamin and sesamolin. We found that the levels of sesamin and sesamolin in mouse serum and brain were higher after the administration of a mixture of sesame extract and turmeric oil (MST) than those after administering sesame extract alone. Serum sesamin and sesamolin contents in the MST-treated group were 23-fold and 15-fold higher, respectively, than those in the sesame extract-treated group. Brain sesamin and sesamolin contents in the MST-treated group were 14-fold and 11-fold higher, respectively, than those in the sesame extract-treated group. These results suggest that turmeric oil is an effective solvent to enhance the bioavailability of sesamin and sesamolin.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 94%

Using Turmeric Oil as a Solvent Improves the Distribution of Sesamin‐Sesamolin in the Serum and Brain of Mice

Iwamoto

Matsumura²,

Yoshioka³

et al. 2019

Lipids

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“…Using this strategy, we have already reported on its application to various crude extracts from plant resources to reveal their inhibitory activities and investigate their active constituents. [43][44][45] This method is expected to be recognized as an efficient strategy for natural product studies.…”

Section: Discussionmentioning

confidence: 99%

Chemical Diversity of β-Secretase Inhibitors From Natural Resources

Murata

2019

Natural Product Communications

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Reports on β-secretase inhibitors of natural origin are listed in order to reveal their chemical diversity. Various types of compounds were found to inhibit β-secretase, and natural resources included a wide spectrum of biological species. Among them, some triterpenes and moracin derivatives, which are nonpeptidic compounds, were determined to be competitive inhibitors. In addition, no peptide compounds were reported from natural resources. These points will be clarified in future studies.

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“…Garlic, ginger, and cinnamon extracts were able to inhibit Aβ aggregation (Guo et al., 2010; Gupta et al., 2009; Peng et al., 2002). In another study, Sesamum indicum seeds and its active phytoconstituents sesamin and sesamolin showed BACE1 inhibitory activity (Matsumura et al., 2016).…”

Section: Introductionmentioning

confidence: 98%

Inhibition of BACE1, MAO‐B, cholinesterase enzymes, and anti‐amyloidogenic potential of selected natural phytoconstituents: Multi‐target‐directed ligand approach

Chowdhury

Kumar

2020

J. Food Biochem.

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Alzheimer's disease (AD) is a neurodegenerative disorder, and multiple factors are involved in disease progression. This is why there is an urgent need to develop novel molecules with multi-target-directed ligands (MTDLs) potential. The current study explores the active phytoconstituents from traditionally used medicinal spices, namely piperine, cinnamaldehyde, eugenol, cuminaldehyde, and alpha-terpinyl acetate for the inhibition of β-secretase, monoamine oxidase, cholinesterase enzymes, anti-aggregation of amyloid β (Aβ) fibrils, and their protective effect against hydrogen peroxide (H 2 O 2) and Aβ-induced toxicity. Eugenol showed inhibitory activity against MAO-B enzyme, free radical scavenging activity, and anti-aggregation activity against Aβ peptides than other phytoconstituents. It also demonstrated a significant cytoprotective effect against H 2 O 2-induced oxidative stress and Aβ-induced cytotoxicity in pheochromocytoma (PC) 12 cells. A molecular docking study of eugenol showed interactions with active site residue of the target enzymes. The study successfully demonstrated that eugenol could have an MTDLs potential better than synthesized drugs used in the treatment of AD. Practical applications The present study demonstrated multi-target-directed ligand potential of eugenol and can be developed to treat complex diseases like Alzheimer's. Eugenol can bind to different Alzheimer's targets such as β-secretase (BACE1), Monoamine oxidase B (MAO-B), Cholinesterase's, and amyloid β 1-42 fibrils and might have a disease-modifying potential. The other natural phytoconstituents such as piperine, cinnamaldehyde, cuminaldehyde, and alpha-terpinyl acetate also demonstrated MTDL potential could also be used for developing novel molecules for disease-modifying effect. It also protects against oxidative stress.

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Inhibitory Activities of Sesame Seed Extract and its Constituents against β-Secretase

Cited by 6 publications

References 16 publications

Using Turmeric Oil as a Solvent Improves the Distribution of Sesamin‐Sesamolin in the Serum and Brain of Mice

Using Turmeric Oil as a Solvent Improves the Distribution of Sesamin‐Sesamolin in the Serum and Brain of Mice

Chemical Diversity of β-Secretase Inhibitors From Natural Resources

Inhibition of BACE1, MAO‐B, cholinesterase enzymes, and anti‐amyloidogenic potential of selected natural phytoconstituents: Multi‐target‐directed ligand approach

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