Inhibitory activity of rabbit milk and medium-chain fatty acids against enteropathogenic Escherichia coli O128

Skřivanová, E.; Molatová, Zuzana; Skřivanová, V.; Marounek, M.

doi:10.1016/j.vetmic.2008.09.083

Cited by 35 publications

(22 citation statements)

References 22 publications

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“…MCFAs dissipate the electrochemical proton gradient and deplete the energy reserves of bacterial cells (Hassinen et al, 1951;Nieman, 1954). In rabbits, MCFAs represent more than one-third of the FAs in milk and protect the offspring against infection (Skřivanová et al, 2009). The role of MCFAs in goats may be similar but less pronounced due to the lower concentration of MCFAs in the milk fat.…”

Section: Resultsmentioning

confidence: 99%

Changes in the composition of goat colostrum and milk fatty acids during the first month of lactation

Marounek¹,

Pavlata²,

Mišurová³

et al. 2012

CZECH J ANIM SCI

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Changes in the composition of colostrum and milk fatty acids during the first month of lactation of ten 3-years-old White Shorthaired goats fed a winter diet were investigated. Thirty-eight fatty acids (FAs) were identified in the milk fat. Saturated FAs accounted for 67.0% of the total determined FAs in colostrum and 62% at 30 days post partum. Monounsaturated FAs made up 28.2% of the total FAs in colostrum and increased with the progress of lactation at the expense of saturated FAs. The percentage of polyunsaturated FAs varied from 4.4 to 4.8%. The major FAs in colostrum and milk were palmitic and oleic acids, followed by stearic and myristic acids (30.1, 25.3, 11.8, 11.4% and 23.6, 30.3, 13.6, 8.6% in colostrum and milk 30 days post partum, respectively). The levels of palmitic and myristic acids in colostrum were higher than in mature milk, whereas the levels of capric, stearic and oleic acids were lower. The medium-chain FA (caprylic, capric, lauric) content increased from 8.7% of FAs in colostrum to 11.1% on the fourth day of lactation. These acids are efficient antimicrobials, thus may contribute to the protection of young goats from microbial pathogens.

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Section: Resultsmentioning

confidence: 99%

Changes in the composition of goat colostrum and milk fatty acids during the first month of lactation

Marounek¹,

Pavlata²,

Mišurová³

et al. 2012

CZECH J ANIM SCI

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“…These two fatty acids showed also superior antimicrobial effects against Candida albicans [17] and other yeast strains [18]. On the contrary, the effect of medium-chain fatty acids against Gram-negative bacteria is much lower; some effect against Helicobacter pylori [19], Campylobacter [20], Salmonella [21] and E. coli [22,23] was reported. Efficacy of capric and lauric acid MAG against bacteria H. pylori was also studied by Petschow et al [24], who found out that antibacterial activity of unsaturated MAG based on dodecene acid (C12:1) was several times lower compared to activity of saturated MAG (C12:0).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial properties of 1‐monoacylglycerols prepared from undecanoic (C11:0) and undecenoic (C11:1) acid

Doležalová

Janiš

Svobodová

et al. 2010

Euro J Lipid Sci & Tech

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Antimicrobial activity of monoacylglycerols (MAG) with odd number of carbons prepared from undecanoic (MAG C11:0) and undecenoic (MAG C11:1) was investigated. Data showed that both studied substances successfully inhibited Gram-positive cocci (Staphylococcus aureus) and spore-forming rods (Bacillus cereus). Gram-negative bacteria were highly resistant against MAG C11:0 and showed considerable tolerance against MAG C11:1. Minimum inhibitory concentration (MIC) of MAG C11:1 was possible to determine for Escherichia coli only. Complete inhibition of three fungi genera (Alternaria, Cladosporium, Trichothecium) was achieved using MAG C11:1 with a concentration higher than 750 mg/ mL. The growth of Aspergillus niger, Mucor racemosus, Phoma, Scopulariopsis, Trichoderma was significantly reduced. Generally, MAG C11:1 was more efficient than MAG C11:0 against all tested microorganisms. Due to a rich production of degradation enzymes, some fungi species surprisingly adapted their metabolism during growth and were even able to utilise tested MAG as a source of carbon.Practical applications: MAG composed of fatty acids with odd number of carbons in molecule are a promising group of substances applicable in food industry and cosmetics. They represent materials with broad spectrum of antimicrobial activity, especially against Gram-positive bacteria. More efficient MAG C11:1 with a double bond in molecule can be recommended for reduction of S. aureus that cause food enterotoxicosis.

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“…They have strong antibacterial activity against Gram-positive cocci (Bergsson et al, 2001) and Escherichia coli (Skřivanová et al, 2009). Moreover, they can improve post-weaning gut development (Tang et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary caprylic and capric acids on piglet performance and mucosal epithelium structure of the ileum

Hańczakowska¹,

Szewczyk²,

Okoń³

2011

J. Anim. Feed Sci.

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Effects of a diet supplemented with caprylic and/or capric acid on piglet performance, apparent digestibility of nutrients, intestinal microflora and small intestine (ileum) structure were investigated. The experiment was performed on 252 piglets (24 litters) allocated to 4 experimental groups (6 litters each). The animals were fed with a standard feed mixture (control) or the same mixture supplemented with 2 g of caprylic or capric acid (groups C 8 and C 10 , respectively) per 1 kg of feed. Group C 8 +C 10 received 1 g of caprylic and 1 g of capric acid. Apparent digestibility was estimated using Cr 2 O 3 as an indicator, while microbiological analyses were performed using standard agar plates. The short-chain fatty acid (SCFA) content of the ileum and caecum digesta was analysed using Varian 340 analyzer. The piglets receiving caprylic or capric acids grew significantly (P<0.01) faster than the control ones (average daily gains during the whole experiment, i.e. between days 1 and 84 of age, were: 288, 269, 278 and 234 g, respectively). The best feed utilization (1.3 kg per kg) was found in animals receiving caprylic acid. The acids also lowered piglet mortality, while significantly increased protein digestibility (P<0.01) and, to a lesser degree (P<0.05), also fibre digestibility. There was no significant difference in acidity of the digesta between control and experimental groups. Capric acid increased the amount of aerobic bacteria as compared to the control group, but the amount of Escherichia coli remained unchanged. The population of Clostridium perfringens was reduced by both caprylic and capric acids (P<0.01). Acids had no effect on SCFA content of the ileum but lowered the acetic acid content of the caecum digesta. Capric acid had the strongest effect on villi, which were significantly higher (306 μm) than in the control group (233 μm). Differences 557 HANCZAKOWSKA E. ET AL.in crypt depth were smaller but the crypts were also the deepest in piglets receiving capric acid. The results suggest that caprylic and capric acids added to the feed improve piglet performance, probably due to positive changes in the mucosal epithelium structure of the ileum.

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Inhibitory activity of rabbit milk and medium-chain fatty acids against enteropathogenic Escherichia coli O128

Cited by 35 publications

References 22 publications

Changes in the composition of goat colostrum and milk fatty acids during the first month of lactation

Changes in the composition of goat colostrum and milk fatty acids during the first month of lactation

Antimicrobial properties of 1‐monoacylglycerols prepared from undecanoic (C11:0) and undecenoic (C11:1) acid

Effects of dietary caprylic and capric acids on piglet performance and mucosal epithelium structure of the ileum

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