Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus

Li, Yinghua; Lin, Zhengfang; Guo, Min; Xia, Yu; Zhao, Mingqi; Wang, Changbing; Xu, Tiantian; Chen, Tianfeng; Zhu, Bing

doi:10.2147/ijn.s140939

Cited by 136 publications

(97 citation statements)

References 47 publications

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“…Li et al demonstrated this strategy of H1N1 viral inhibition using oseltamivir (OTV) decorated SeNPs (Se@OTV). 134 This strategy could be effectively evaluated in vitro in case of NiV inhibition. Likewise modulation of viral transcription using MWCTs-ribavirin by Zhu et al, 135 targeted binding on conservative regions on viral genome using TiO 2 NPs and polylysine (PL)containing oligonucleotides nanocomposite by Levina et al 136 and silencing viral replication with the help of solid lipid NPs by Torrecilla et al 137 etc.…”

Section: Possible Nano-based Approach For Niv Inhibitionmentioning

confidence: 99%

Nano-based approach to combat emerging viral (NIPAH virus) infection

Kerry

Malik

Redda

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

109

107

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Emergence of new virus and their heterogeneity are growing at an alarming rate. Sudden outburst of Nipah virus (NiV) has raised serious question about their instant management using conventional medication and diagnostic measures. A coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. But in concurrent to resourceful and precise execution of nano-based medication, there is an ultimate need of concrete understanding of the NIV pathogenesis. Moreover, to amplify the effectiveness of nano-based approach in a conquest against NiV, a list of developed nanosystem with antiviral activity is also a prerequisite. Therefore the present review provides a meticulous cognizance of cellular and molecular pathogenesis of NiV. Conventional as well several nano-based diagnosis experimentations against viruses have been discussed. Lastly, potential efficacy of different forms of nano-based systems as convenient means to shield mankind against NiV has also been introduced.

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Section: Possible Nano-based Approach For Niv Inhibitionmentioning

confidence: 99%

Nano-based approach to combat emerging viral (NIPAH virus) infection

Kerry

Malik

Redda

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

109

107

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“…Selenium nanoparticles (SeNPs) was fabricated according to previous studies (Li et al, 2017). In brief, 1 mM vitamin C (Vc) solution, 0.2 M Na 2 SeO 3 solution, and 1.5 mg/mL RGDfC solution were freshly prepared.…”

Section: Fabrication and Characterizations Of Nanoparticlementioning

confidence: 99%

Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer

et al. 2019

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2020) Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer, Drug Delivery, 27:1, 15-25, ABSTRACT Small interfering RNA (siRNA) exhibits great potential as a novel therapeutic option due to its highly sequence-specific ability to silence genes. However, efficient and safe delivery carriers are required for developing novel therapeutic paradigms. Thus, the successful development of efficient delivery platforms for siRNA is a crucial issue for the development of siRNA-based drugs in cancer treatments. In this study, biocompatible selenium nanoparticles (SeNPs) were loaded with RGDfC peptide to fabricate tumor-targeting gene delivery vehicle RGDfC-SeNPs. Subsequently, RGDfC-SeNPs were loaded with Derlin1-siRNA to fabricate RGDfC-Se@siRNA, which are functionalized selenium nanoparticles. RGDfC-Se@siRNA showed greater uptake in HeLa cervical cancer cells in comparison with that in human umbilical vein endothelial cells (HUVECs), verifying the RGDfC-mediated specific uptake of RGDfC-Se@siRNA. RGDfC-Se@siRNA was capable of entering HeLa cells via clathrin-associated endocytosis, and showed faster siRNA release in a cancer cell microenvironment in comparison with a normal physiological environment. qPCR and western blotting assays both indicated that RGDfC-Se@siRNA exhibited an obvious gene silencing efficacy in HeLa cells. RGDfC-Se@siRNA suppressed the invasion, migration and the proliferation of HeLa cells, and triggered HeLa cell apoptosis. Moreover, RGDfC-Se@siRNA induced the disruption of mitochondrial membrane potentials. Meanwhile, RGDfC-Se@siRNA enhanced the generation of reactive oxygen species (ROS) in HeLa cell, suggesting that mitochondrial dysfunction mediated by ROS might play a significant role in RGDfC-Se@siRNA-induced apoptosis. Interestingly, RGDfC-SeNPs@siRNA exhibited significant antitumor activity in a HeLa tumor-bearing mouse model. Additionally, RGDfC-SeNPs@siRNA is nontoxic to main organ of mouse. The above results indicate that RGDfC-Se@siRNA provides a promising potential for cervical cancer therapy. ARTICLE HISTORY

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“…Wang et al [17] reported that the broad spectrum antiviral polyoxometalate may become a novel antiviral drug. In our previous research, selenium nanoparticles (SeNPs) have been proven to exhibit significant antiviral activity [18,19]. Selenium as an essential trace element control some key biological processes containing specific enzyme modulation and reactive oxygen species (ROS) elimination [19].…”

Section: Introductionmentioning

confidence: 99%

“…In our previous research, selenium nanoparticles (SeNPs) have been proven to exhibit significant antiviral activity [18,19]. Selenium as an essential trace element control some key biological processes containing specific enzyme modulation and reactive oxygen species (ROS) elimination [19]. A deficiency in selenium could cause susceptibility to the virus infection [20].…”

Section: Introductionmentioning

confidence: 99%

Functionalized selenium nanoparticles enhance the anti-EV71 activity of oseltamivir in human astrocytoma cell model

Zhong

Xia

Hua

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Enterovirus 71 (EV71) which commonly caused the hand-foot-mouth disease (HFMD) has become one of public health challenges worldwide. However, no effective vaccines or drugs for this disease has been developed. Thus, there is an urgent need to find a new strategy for treating the EV71 infection. Oseltamivir (OT) is an effective antiviral agent, but continuous use of oseltamivir leads to a diminished therapeutic effect in the clinic. In order to improve the antiviral activity of oseltamivir, oseltamivir was loaded onto surfaces of selenium nanoparticles (SeNPs) to fabricate a functionalized antiviral nanoparticles SeNPs@OT. The size of SeNPs@OT was tested by TEM and dynamic light scattering. The chemical structure and elemental composition of SeNPs@OT were analyzed by FT-IR and EDX, respectively. SeNPs@OT exhibited good stability and effective drug release in serum and PBS. SeNPs@OT efficiently entered into human astrocyte U251 cells (host cells) via clathrin-associated endocytosis and inhibited EV71 proliferation, which could protect EV71-infected U251 cells from apoptosis through mitochondrial pathway. Furthermore, SeNPs@OT inhibited EV71 activity probably by reducing the generation of reactive oxygen species in EV71-infected U251 cells. Interestingly, SeNPs obviously enhanced antiviral activity of oseltamivir in the anti-EV71 cell model. Taken together, SeNPs@OT is a promising antiviral drug candidate for EV71 infection.

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Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus

Cited by 136 publications

References 47 publications

Nano-based approach to combat emerging viral (NIPAH virus) infection

Nano-based approach to combat emerging viral (NIPAH virus) infection

Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer

Functionalized selenium nanoparticles enhance the anti-EV71 activity of oseltamivir in human astrocytoma cell model

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