Inhibitory and Acceleratory Effects of <i>Inonotus obliquus</i> on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells

Yan, Zheng‐Fei; Yang, Yang; Tian, Fenghua; Mao, Xinxin; Li, Yu; Li, Changtian

doi:10.1155/2014/259836

Cited by 19 publications

(15 citation statements)

References 28 publications

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“…Phenolic compounds have been reported to be responsible for the anti-tyrosinase activity of mushroom extracts, but Yan et al [24] also isolated two steroidal triterpenes (betulin and trametenolic acid) from Inonotus obliquus (Ach. ex Pers.)…”

Section: Resultsmentioning

confidence: 99%

Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties

et al. 2016

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Abstract:The cosmetic industry is in a constant search for natural compounds or extracts with relevant bioactive properties, which became valuable ingredients to design cosmeceutical formulations. Mushrooms have been markedly studied in terms of nutritional value and medicinal properties. However, there is still slow progress in the biotechnological application of mushroom extracts in cosmetic formulations, either as antioxidants, anti-aging, antimicrobial, and anti-inflammatory agents or as hyperpigmentation correctors. In the present work, the cosmeceutical potential of ethanolic extracts prepared from Agaricus bisporus, Pleurotus ostreatus, and Lentinula edodes was analyzed in terms of anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial activities. The extracts were characterized in terms of phenolic acids and ergosterol composition, and further incorporated in a base cosmetic cream to achieve the same bioactive purposes. From the results obtained, the final cosmeceutical formulations presented 85%-100% of the phenolic acids and ergosterol levels found in the mushroom extracts, suggesting that there was no significant loss of bioactive compounds. The final cosmeceutical formulation also displayed all the ascribed bioactivities and as such, mushrooms can further be exploited as natural cosmeceutical ingredients.

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Section: Resultsmentioning

confidence: 99%

Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties

et al. 2016

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“…Among three lanostane triterpenoids, inotodiol alone was reported to inhibit cancer cell proliferation (16). In comparison, inotodiol and lanosterol reportedly increased tyrosinase activities as well as melanin content in B16 melanoma cells (37). Further, it has been shown that the activity of another triterpene lanostane, ganoderic acid, on the growth and invasiveness of cancer cells is linked to the hydroxylation of its structure, as the inactive compound is not hydroxylated (38), suggesting that hydroxylation of lanosterol may be responsible for its potent immunological activities.…”

Section: Discussionmentioning

confidence: 97%

Inotodiol From Inonotus obliquus Chaga Mushroom Induces Atypical Maturation in Dendritic Cells

et al. 2021

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Dendritic cells (DCs) have the ability to stimulate naïve T cells that coordinate subsequent adaptive response toward an inflammatory response or tolerance depending on the DC differentiation level. Inotodiol, a lanostane triterpenoid found in Inonotus obliquus (wild Chaga mushroom), is a natural compound with a wide range of biological activities. In this study, we investigated whether inotodiol promotes the maturation of bone marrow-derived DCs (BMDCs) and inotodiol-treated BMDCs induce T cell activation. Inotodiol increased the expression of surface maturation markers, including MHC-I, MHC-II, CD86, and CD40, on BMDCs without affecting the production of various cytokines, including TNF-α and IL-12p40 in these cells. T cells primed with inotodiol-treated BMDCs proliferated and produced IL-2, without producing other cytokines, including IL-12p40 and IFN-γ. Injection of inotodiol into mice induced maturation of splenic DCs and IL-2 production, and the administration of inotodiol and inotodiol-treated BMDCs induced the proliferation of adoptively transferred CD8+ T cells in vivo. The phosphatidylinositol-3-kinase inhibitor wortmannin abrogated the upregulation of Akt phosphorylation and CD86 and MHC-II expression induced by inotodiol. However, inotodiol failed to induce phosphorylation of the IκB kinase and degradation of IκB-α, and increased expression of CD86 induced by inotodiol was not blocked by an IκB kinase inhibitor. These results suggest that inotodiol induces a characteristic type of maturation in DCs through phosphatidylinositol-3-kinase activation independent of NF-κB, and inotodiol-treated DCs enhance T cell proliferation and IL-2 secretion.

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“…Pilát, also known as "chaga mushroom" is a medicinal mushroom commonly used in Russia and other North-European countries with reported anti-tumour and immunomodulatory properties (Taofiq et al, 2016). Studies were conducted by Yan et al (2014) who investigated the tyrosinase inhibitory activity of petroleum ether and n-butanol extracts of Inonotus obliquus. At 10 Mg/mL, petroleum ether and n-butanol extracts showed tyrosinase inhibitory activity with IC 50 value of 3.81 and 6.32 Mg/mL, respectively.…”

Section: Anti-tyrosinase Activitymentioning

confidence: 99%

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Taofiq

González-Paramás

Martins

et al. 2016

Industrial Crops and Products

159

114

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a b s t r a c tThe cosmetic industry is constantly in search of ingredients from natural sources because of their competitive effectiveness and lower toxicity effects. Mushrooms have been an important part of our diet for years and are now finding their way as cosmetic ingredients, either as cosmeceutical or as nutricosmetics. The present review focuses on the most relevant activities of mushroom extracts, as well as on their bioactive compounds, which make them interesting ingredients for cosmetic formulations. Mushroom extracts, as well as their bioactive metabolites, revealed anti-tyrosinase, anti-hyaluronidase, anti-collagenase and anti-elastase activity. Emphasis was also given to their important anti-oxidant, antimicrobial and antiinflammatory potential, topics largely studied by numerous authors, making them very versatile and multi-functional cosmetic ingredients. Some of the bioactive compounds and the mechanism responsible for the activities ascribed to mushrooms were highlighted. Other activities were identified as needing to be further studied in order to identify the major compounds contributing to the target activity, as well as their mechanisms of action. Based on the above findings, mushroom extracts, as well as their bioactive metabolites, constitute important ingredients that can help to combat aging, reduce the severity of inflammatory skin disease and correct hyperpigmentation disorders. These findings and claims must be correctly supported by clinical trials and in vivo studies.

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Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells

Cited by 19 publications

References 28 publications

Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties

Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties

Inotodiol From Inonotus obliquus Chaga Mushroom Induces Atypical Maturation in Dendritic Cells

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

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