Inhibitory Effect of Açaí (Euterpe oleracea Mart.) Pulp on IgE-Mediated Mast Cell Activation

Horiguchi, Tomoko; N, Ishiguro; Chihara, Kazuyasu; Ogi, Kazuhiro; Nakashima, Kenichiro; Sada, Kiyonao; Hori-Tamura, Naoko

doi:10.1021/jf2005707

Cited by 14 publications

(7 citation statements)

References 37 publications

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“…Its in vitro anti-inflammatory effects have also been demonstrated by other researchers. Pretreatment of IgE-sensitized mouse primary cultured mast cells with açaí pulp showed a dramatic dose-dependent suppression of antigen-induced degranulation, transcription of selective cytokine genes, and inhibition of FcεRI signaling pathways as well as the FcεRI-mediated complementary signaling pathway, suggesting the pulp is a potent inhibitor of IgE-mediated mast cell activation . Açaı́ pulp anthocyanin-rich extracts have been shown to reduce inflammatory stress signaling in BV-2 (hippocampal) mouse microglia .…”

Section: Research Strategies: An Example Using Açaí Fruit Pulpmentioning

confidence: 99%

“…Pretreatment of IgE-sensitized mouse primary cultured mast cells with acai ́pulp showed a dramatic dosedependent suppression of antigen-induced degranulation, transcription of selective cytokine genes, and inhibition of FcεRI signaling pathways as well as the FcεRI-mediated complementary signaling pathway, suggesting the pulp is a potent inhibitor of IgE-mediated mast cell activation. 146 Acaı ṕulp anthocyanin-rich extracts have been shown to reduce inflammatory stress signaling in BV-2 (hippocampal) mouse microglia. 147 Results from this study showed that pretreatment of microglia with individual acaı ́pulp fractions was protective against LPS-induced NO release, COX-2 expression, nitrite production, inducible nitrous oxide synthase expression, p38 mitogen-activated protein kinases (p38-MAPK) expression, and TNF-α and NF-κB release.…”

Section: ■ Anti-inflammatory Dietary Components and Their Mechanismsmentioning

confidence: 99%

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Mitigation of Inflammation with Foods

Schauss

2012

J. Agric. Food Chem.

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Constant overproduction of pro-inflammatory molecules leads to chronic inflammation. Unlike acute inflammation, which is essential for healing, chronic inflammation can delay healing and, if left unchecked, contribute to a host of diseases. There is growing evidence that some dietary factors can play important roles in maintaining health and even reversing the progression of chronic diseases, with anti-inflammatory effects as important underlying mechanism. Such findings add to the body of evidence that certain dietary components, including polyphenols and other types of compounds, found in various dietary factors including fruits, berries, vegetables, nuts, whole grains, and foods of marine origin, can play an important role in attenuating and mitigating chronic pro-inflammatory processes associated with chronic diseases.

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Section: Research Strategies: An Example Using Açaí Fruit Pulpmentioning

confidence: 99%

Section: ■ Anti-inflammatory Dietary Components and Their Mechanismsmentioning

confidence: 99%

Mitigation of Inflammation with Foods

Schauss

2012

J. Agric. Food Chem.

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“…Exposure of IgE-sensitized mouse primary cultured mast cells to EO pulp resulted in suppression of IgE-mediated degranulation and transcription of the cytokine genes from a cultured mast cell line originated from rat basophilic leukemia (RBL-2H3), selectively inhibited FcεRI signaling pathways and suppressed the FcεRI-mediated complementary signaling pathway. In general, EO inhibited IgE-mediated mast cell activation [ 85 ].…”

Section: Biological Eo Activities: Application In the Prevention Amentioning

confidence: 99%

The Use of Euterpe oleracea Mart. As a New Perspective for Disease Treatment and Prevention

et al. 2020

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Euterpe oleracea Mart. (EO), popularly known as açaí, belongs to the Arecaceae family and grows abundantly in Brazil. The fruit of this palm tree is widely used because of its anti-inflammatory and antioxidant properties. In this review, a search for literature and patent technological prospecting has been performed on the use of EO to treat and prevent diseases as well as to prepare pharmaceutical formulations. EO leaves, fruits, and oil stand out for their large number of pharmacological activities such as anti-inflammatory, antioxidant, antimicrobial, antinociceptive, anticancer, anti-atherogenic, and healing activities, protection against metabolic syndromes such as diabetes, hypertension, and hyperlipidemia, and protection of organs such as lung, kidney, liver, heart, and nervous system. While the phytochemical composition is intrinsically linked to identified biological activities, discoveries of the past decade concerning the use of this species have shown pharmacological alternatives mainly in the treatment and prevention of breast cancer and metabolic syndromes. Although studies and inventions on the use of EO though are believed to have been important in light of the pharmacological activities found, few clinical and toxicity tests have been performed. Nevertheless, with the increase of interest in EO, this species is believed to be only at the beginning of the breakthroughs in the development of promising products for the pharmaceutical industry.

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“…The Linus Pauling Institute and the European Food Safety Authority state that dietary anthocyanins and other flavonoids have little or no antioxidant value after digestion. 2 It should be noted that in 2011, Hiriguchi and colleagues 3 found that the properties in the acai berry suppressed the degradation of cellular integrity in mice. In a recent human study of 10 overweight individuals who consumed acai berries for 30 days, lower fasting glucose and insulin levels as well as lower cholesterol levels were found, but there was no effect on blood pressure.…”

Section: The Natural Acai Berrymentioning

confidence: 99%